Transcranial electrical stimulation modulates emotional experience and metabolites in the prefrontal cortex in a donation task.

Humans Transcranial Direct Current Stimulation Male Female Prefrontal Cortex / metabolism Adult Emotions / physiology Young Adult gamma-Aminobutyric Acid / metabolism Glutamic Acid / metabolism Altruism Glutamine / metabolism Magnetic Resonance Spectroscopy / methods Dorsolateral Prefrontal Cortex / metabolism

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
20 06 2024
Historique:
received: 28 09 2023
accepted: 13 06 2024
medline: 21 6 2024
pubmed: 21 6 2024
entrez: 20 6 2024
Statut: epublish

Résumé

Understanding the neural, metabolic, and psychological mechanisms underlying human altruism and decision-making is a complex and important topic both for science and society. Here, we investigated whether transcranial Direct Current Stimulation (tDCS) applied to two prefrontal cortex regions, the ventromedial prefrontal cortex (vmPFC, anode) and the right dorsolateral prefrontal cortex (DLPFC, cathode) can induce changes in self-reported emotions and to modulate local metabolite concentrations. We employed in vivo quantitative MR Spectroscopy in healthy adult participants and quantified changes in GABA and Glx (glutamate + glutamine) before and after five sessions of tDCS delivered at 2 mA for 20 min (active group) and 1 min (sham group) while participants were engaged in a charitable donation task. In the active group, we observed increased levels of GABA in vmPFC. Glx levels decreased in both prefrontal regions and self-reported happiness increased significantly over time in the active group. Self-reported guiltiness in both active and sham groups tended to decrease. The results indicate that self-reported happiness can be modulated, possibly due to changes in Glx concentrations following repeated stimulation. Therefore, local changes may induce remote changes in the reward network through interactions with other metabolites, previously thought to be unreachable with noninvasive stimulation techniques.

Identifiants

DOI: 10.1038/s41598-024-64876-x PMID: 38902321
pubmed: 38902321
doi: 10.1038/s41598-024-64876-x
pii: 10.1038/s41598-024-64876-x
doi:

Substances chimiques

gamma-Aminobutyric Acid 56-12-2
Glutamic Acid 3KX376GY7L
Glutamine 0RH81L854J

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

14271

Subventions

Organisme : Conselho Nacional de Desenvolvimento Científico e Tecnológico
ID : 465346/2014
Organisme : Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
ID : E-26/200.872/2018

Informations de copyright

© 2024. The Author(s).

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Auteurs

Luiza Mugnol-Ugarte (L)

Cognitive Neuroscience and Neuroinformatics Unit, The D'Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil. mugnol.luiza@gmail.com.

Tiago Bortolini (T)

Cognitive Neuroscience and Neuroinformatics Unit, The D'Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil.

Bo Yao (B)

Department of Psychology, Lancaster University, Lancaster, United Kingdom.

Mark Mikkelsen (M)

Department of Radiology, Weill Cornell Medicine, New York, United States of America.

Marina Carneiro Monteiro (M)

Cognitive Neuroscience and Neuroinformatics Unit, The D'Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil.

Ana Carolina Andorinho de Freitas Ferreira (AC)

Cognitive Neuroscience and Neuroinformatics Unit, The D'Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil.

Ivanei Bramatti (I)

Cognitive Neuroscience and Neuroinformatics Unit, The D'Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil.

Bruno Melo (B)

Cognitive Neuroscience and Neuroinformatics Unit, The D'Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil.

Sebastian Hoefle (S)

Cognitive Neuroscience and Neuroinformatics Unit, The D'Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil.

Fernanda Meireles (F)

Cognitive Neuroscience and Neuroinformatics Unit, The D'Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil.

Jorge Moll (J)

Cognitive Neuroscience and Neuroinformatics Unit, The D'Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil.

Gorana Pobric (G)

Division of Psychology, Communication and Human Neuroscience, The University of Manchester, Manchester, United Kingdom.

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