Hypocapnia in women with fibromyalgia.
acid
base balance
chronic hyperventilation
fibromyalgia
hypocapnia
Journal
Scandinavian journal of pain
ISSN: 1877-8879
Titre abrégé: Scand J Pain
Pays: Germany
ID NLM: 101520867
Informations de publication
Date de publication:
01 Jan 2024
01 Jan 2024
Historique:
received:
12
01
2024
accepted:
27
05
2024
medline:
22
6
2024
pubmed:
22
6
2024
entrez:
22
6
2024
Statut:
epublish
Résumé
The purpose of this study was to investigate whether people with fibromyalgia (FM) have dysfunctional breathing by examining acid-base balance and comparing it with healthy controls. Thirty-six women diagnosed with FM and 36 healthy controls matched for age and gender participated in this cross-sectional study. To evaluate acid-base balance, arterial blood was sampled from the radial artery. Carbon dioxide, oxygen, bicarbonate, base excess, pH and lactate were analysed for between-group differences. Blood gas analyses were performed stepwise on each individual to detect acid-base disturbance, which was categorized as primary respiratory and possible compensation indicating chronicity. A three-step approach was employed to evaluate pH, carbon dioxide and bicarbonate in this order. Women with FM had significantly lower carbon dioxide pressure ( In this study, we could identify a subgroup of individuals with FM who may be characterized as mild chronic hyperventilators. The results might point to a plausible dysfunctional breathing in some women with FM.
Identifiants
pubmed: 38907689
pii: sjpain-2024-0003
doi: 10.1515/sjpain-2024-0003
doi:
Substances chimiques
Lactic Acid
33X04XA5AT
Carbon Dioxide
142M471B3J
Bicarbonates
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2024 the author(s), published by De Gruyter.
Références
Theoharides TC, Tsilioni I, Arbetman L, Panagiotidou S, Stewart JM, Gleason RM, et al. Fibromyalgia syndrome in need of effective treatments. J Pharmacol Exp Ther. 2015;355(2):255–63.
Siracusa R, Paola RD, Cuzzocrea S, Impellizzeri D. Fibromyalgia: Pathogenesis, mechanisms, diagnosis and treatment options update. Int J Mol Sci. 2021;22(8). 10.3390/ijms22083891 .
doi: 10.3390/ijms22083891
Martínez-Martínez LA, Mora T, Vargas A, Fuentes-Iniestra M, Martínez-Lavín M. Sympathetic nervous system dysfunction in fibromyalgia, chronic fatigue syndrome, irritable bowel syndrome, and interstitial cystitis: A review of case-control studies. J Clin Rheumatol. 2014;20(3):146–50.
Reyes Del Paso GA, de la Coba P. Reduced activity, reactivity and functionality of the sympathetic nervous system in fibromyalgia: An electrodermal study. PLoS One. 2020;15(10):e0241154.
Krock E, Morado-Urbina CE, Menezes J, Hunt MA, Sandström A, Kadetoff D, et al. Fibromyalgia patients with elevated levels of anti-satellite glia cell immunoglobulin G antibodies present with more severe symptoms. Pain. 2023;164(8):1828–40.
Gaudreault N, Boulay P. Cardiorespiratory fitness among adults with fibromyalgia. Breathe (Sheff). 2018;14(2):e25–33.
Zambolin F, Duro-Ocana P, Faisal A, Bagley L, Gregory WJ, Jones AW, et al. Fibromyalgia and chronic fatigue syndromes: A systematic review and meta-analysis of cardiorespiratory fitness and neuromuscular function compared with healthy individuals. PLoS One. 2022;17(10):e0276009.
Cai L, Gonzales T, Wheeler E, Kerrison ND, Day FR, Langenberg C, et al. Causal associations between cardiorespiratory fitness and type 2 diabetes. Nat Commun. 2023;14(1):3904.
Jonsson K, Peterson M. Peak expiratory flow rate and thoracic mobility in people with fibromyalgia. A cross sectional study. Scand J Pain. 2019;19(4):755–63.
Forti M, Zamunér AR, Andrade CP, Silva E. Lung function, respiratory muscle strength, and thoracoabdominal mobility in women with fibromyalgia syndrome. Respir Care. 2016;61(10):1384–90.
Tipton MJ, Harper A, Paton JFR, Costello JT. The human ventilatory response to stress: rate or depth? J Physiol. 2017;595(17):5729–52.
Stephen S, Brandt C, Olivier B. Neck pain and disability: Are they related to dysfunctional breathing and stress? Physiother Can. 2022;74(2):158–64.
Dimitriadis Z, Kapreli E, Strimpakos N, Oldham J. Hypocapnia in patients with chronic neck pain: association with pain, muscle function, and psychologic states. Am J Phys Med Rehabil. 2013;92(9):746–54.
Brack T, Jubran A, Tobin MJ. Dyspnea and decreased variability of breathing in patients with restrictive lung disease. Am J Respir Crit Care Med. 2002;165(9):1260–4.
Sarton E, Dahan A, Teppema L, Berkenbosch A, van den Elsen M, van Kleef J. Influence of acute pain induced by activation of cutaneous nociceptors on ventilatory control. Anesthesiology. 1997;87(2):289–96.
Jafari H, Courtois I, Van den Bergh O, Vlaeyen JWS, Van Diest I. Pain and respiration: A systematic review. Pain. 2017;158(6):995–1006.
López-de-Uralde-Villanueva I, Del Corral T, Salvador-Sánchez R, Angulo-Díaz-Parreño S, López-Marcos JJ, Plaza-Manzano G. Respiratory dysfunction in patients with chronic neck pain: systematic review and meta-analysis. Disabil Rehabil. 2023;45(15):2422–33.
Dimitriadis Z, Kapreli E, Strimpakos N, Oldham J. Respiratory dysfunction in patients with chronic neck pain: What is the current evidence? J Bodyw Mov Ther. 2016;20(4):704–14.
McLaughlin L, Goldsmith CH, Coleman K. Breathing evaluation and retraining as an adjunct to manual therapy. Man Ther. 2011;16(1):51–2.
Naschitz JE, Mussafia-Priselac R, Kovalev Y, Zaigraykin N, Slobodin G, Elias N, et al. Patterns of hypocapnia on tilt in patients with fibromyalgia, chronic fatigue syndrome, nonspecific dizziness, and neurally mediated syncope. Am J Med Sci. 2006;331(6):295–303.
Wolfe F, Smythe HA, Yunus MB, Bennett RM, Bombardier C, Goldenberg DL, et al. The American College of Rheumatology 1990 criteria for the classification of fibromyalgia. Report of the Multicenter Criteria Committee. Arthritis Rheum. 1990;33(2):160–72.
Tucker AM, Johnson TN. Acid-base disorders: A primer for clinicians. Nutr Clin Pract. 2022;37(5):980–9.
Sergi M, Rizzi M, Braghiroli A, Sarzi Puttini P, Greco M, Cazzola M, et al. Periodic breathing during sleep in patients affected by fibromyalgia syndrome. Eur Respir J. 1999;14(1):203–8.
Wilhelm FH, Gevirtz R, Roth WT. Respiratory dysregulation in anxiety, functional cardiac, and pain disorders. Assessment, phenomenology, and treatment. Behav Modif. 2001;25(4):513–45.
Laffey JG, Kavanagh BP. Hypocapnia. N Engl J Med. 2002;347(1):43–53.
Gilbert C. Hyperventilation and the body. Accid Emerg Nurs. 1999;7(3):130–40.
DiNicolantonio JJ, O’Keefe J. Low-grade metabolic acidosis as a driver of chronic disease: A 21st century public health crisis. Open Heart. 2021;8(2). 10.1136/openhrt-2021-001730 .
doi: 10.1136/openhrt-2021-001730
Ho JQ, Abramowitz MK. Clinical consequences of metabolic acidosis-muscle. Adv Chronic Kidney Dis. 2022;29(4):395–405.