Mixed-Micelle in Situ Gel as a Candidate for Oral Inflammatory Ulcerative Diseases.
Micelles
Dexamethasone
/ administration & dosage
Chitosan
/ chemistry
Gels
/ chemistry
Drug Delivery Systems
/ methods
Poloxamer
/ chemistry
Drug Liberation
Surface-Active Agents
/ chemistry
Chemistry, Pharmaceutical
/ methods
Hydrogels
/ chemistry
Anti-Inflammatory Agents
/ administration & dosage
Nanoparticles
/ chemistry
Drug Carriers
/ chemistry
Rheology
/ methods
Oral Ulcer
/ drug therapy
Administration, Oral
Lipids
/ chemistry
Oleic Acid
/ chemistry
Chitosan
Hydrogel
In situ gel
Mixed-micelle
Poloxamer 407
Journal
AAPS PharmSciTech
ISSN: 1530-9932
Titre abrégé: AAPS PharmSciTech
Pays: United States
ID NLM: 100960111
Informations de publication
Date de publication:
25 Jun 2024
25 Jun 2024
Historique:
received:
09
03
2024
accepted:
06
06
2024
medline:
26
6
2024
pubmed:
26
6
2024
entrez:
25
6
2024
Statut:
epublish
Résumé
The current treatment for oral inflammatory ulcerative diseases has limitations. In situ forming hydrogels have shown great potential to deliver therapeutic substances for drug delivery to the buccal cavity. This study aimed to prepare and characterize lipid- and surfactant-based mixed micelle in situ gel (MIG) and evaluate whether it can offer more favorable properties than the in situ gel for effective treatment of the disease. Dexamethasone was incorporated into the MIGs particles, based on Poloxamer 407 and chitosan. The lower gelation time at 37 ℃ was considered a criterion to select superior formulations among the different lipid- and surfactant-based candidates. Further characterization was performed to evaluate the opted formulations regarding morphology, physical stability, rheology, texture, and release profile. All formulations were thermoresponsive and had a shorter gelation time as the temperature increased. Dexamethasone was released in a highly controlled manner, and morphological evaluation revealed that the mixed micelle in situ gels had spherical nanoparticles. Thixotropic behavior was observed in all MIGs, indicating a prolonged retention time of the formulation after oral administration. This study has shown that among different MIGs, the one with oleic acid is a more promising candidate than the in situ gel and other MIGs for drug delivery to the buccal cavity.
Identifiants
pubmed: 38918282
doi: 10.1208/s12249-024-02862-2
pii: 10.1208/s12249-024-02862-2
doi:
Substances chimiques
Micelles
0
Dexamethasone
7S5I7G3JQL
Chitosan
9012-76-4
Gels
0
Poloxamer
106392-12-5
Surface-Active Agents
0
Hydrogels
0
Anti-Inflammatory Agents
0
Drug Carriers
0
Lipids
0
Oleic Acid
2UMI9U37CP
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
144Informations de copyright
© 2024. The Author(s), under exclusive licence to American Association of Pharmaceutical Scientists.
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