Age differentially impacts adaptive immune responses induced by adenoviral versus mRNA vaccines against COVID-19.


Journal

Nature aging
ISSN: 2662-8465
Titre abrégé: Nat Aging
Pays: United States
ID NLM: 101773306

Informations de publication

Date de publication:
25 Jun 2024
Historique:
received: 30 06 2023
accepted: 02 05 2024
medline: 26 6 2024
pubmed: 26 6 2024
entrez: 25 6 2024
Statut: aheadofprint

Résumé

Adenoviral and mRNA vaccines encoding the viral spike (S) protein have been deployed globally to contain severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Older individuals are particularly vulnerable to severe infection, probably reflecting age-related changes in the immune system, which can also compromise vaccine efficacy. It is nonetheless unclear to what extent different vaccine platforms are impacted by immunosenescence. Here, we evaluated S protein-specific immune responses elicited by vaccination with two doses of BNT162b2 or ChAdOx1-S and subsequently boosted with a single dose of BNT162b2 or mRNA-1273, comparing age-stratified participants with no evidence of previous infection with SARS-CoV-2. We found that aging profoundly compromised S protein-specific IgG titers and further limited S protein-specific CD4

Identifiants

pubmed: 38918602
doi: 10.1038/s43587-024-00644-w
pii: 10.1038/s43587-024-00644-w
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : DH | National Institute for Health Research (NIHR)
ID : COV-LT2-0041

Investigateurs

Elena Barbieri (E)
Tatiana Bernardi (T)
Michela Boni (M)
Linda Dall'Olio (L)
Martina De Laurentis (M)
Caterina Fiorini (C)
Michele Fiorini (M)
Maurizio Govoni (M)
Margherita Neri (M)
Fabio Palma (F)
Franco Romagnoni (F)

Informations de copyright

© 2024. The Author(s), under exclusive licence to Springer Nature America, Inc.

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Auteurs

Beatrice Dallan (B)

Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Ferrara, Italy.

Davide Proietto (D)

Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Ferrara, Italy.

Martina De Laurentis (M)

Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Ferrara, Italy.

Eleonora Gallerani (E)

Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Ferrara, Italy.

Mara Martino (M)

Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Ferrara, Italy.

Sara Ghisellini (S)

Laboratory of Clinical Pathology, University Hospital St. Anna, Ferrara, Italy.

Amedeo Zurlo (A)

Department of Medical Sciences, University of Ferrara, Geriatrics Unit, University Hospital of Ferrara, Ferrara, Italy.

Stefano Volpato (S)

Department of Medical Sciences, University of Ferrara, Geriatrics Unit, University Hospital of Ferrara, Ferrara, Italy.

Benedetta Govoni (B)

Department of Medical Sciences, University of Ferrara, Geriatrics Unit, University Hospital of Ferrara, Ferrara, Italy.

Michela Borghesi (M)

Department of Economics and Management, University of Ferrara, Ferrara, Italy.

Valentina Albanese (V)

Department of Environmental and Prevention Sciences, University of Ferrara, Ferrara, Italy.

Victor Appay (V)

Université de Bordeaux, CNRS UMR 5164, INSERM ERL 1303, ImmunoConcEpT, Bordeaux, France.

Stefano Bonnini (S)

Department of Economics and Management, University of Ferrara, Ferrara, Italy.

Sian Llewellyn-Lacey (S)

Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff, UK.

Salvatore Pacifico (S)

Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Ferrara, Italy.

Laura Grumiro (L)

Department of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy.

Martina Brandolini (M)

Department of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy.

Simona Semprini (S)

Unit of Microbiology, Greater Romagna Area Hub Laboratory, Cesena, Italy.

Vittorio Sambri (V)

Department of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy.
Unit of Microbiology, Greater Romagna Area Hub Laboratory, Cesena, Italy.

Kristin Ladell (K)

Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff, UK.

Helen M Parry (HM)

Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.

Paul A H Moss (PAH)

Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.

David A Price (DA)

Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff, UK.
Systems Immunity Research Institute, Cardiff University School of Medicine, Cardiff, UK.

Antonella Caputo (A)

Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Ferrara, Italy.

Riccardo Gavioli (R)

Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Ferrara, Italy.

Francesco Nicoli (F)

Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Ferrara, Italy. francesco.nicoli@unife.it.

Classifications MeSH