Claustrum neurons projecting to the anterior cingulate restrict engagement during sleep and behavior.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
26 Jun 2024
26 Jun 2024
Historique:
received:
08
10
2022
accepted:
14
05
2024
medline:
27
6
2024
pubmed:
27
6
2024
entrez:
26
6
2024
Statut:
epublish
Résumé
The claustrum has been linked to attention and sleep. We hypothesized that this reflects a shared function, determining responsiveness to stimuli, which spans the axis of engagement. To test this hypothesis, we recorded claustrum population dynamics from male mice during both sleep and an attentional task ('ENGAGE'). Heightened activity in claustrum neurons projecting to the anterior cingulate cortex (ACCp) corresponded to reduced sensory responsiveness during sleep. Similarly, in the ENGAGE task, heightened ACCp activity correlated with disengagement and behavioral lapses, while low ACCp activity correlated with hyper-engagement and impulsive errors. Chemogenetic elevation of ACCp activity reduced both awakenings during sleep and impulsive errors in the ENGAGE task. Furthermore, mice employing an exploration strategy in the task showed a stronger correlation between ACCp activity and performance compared to mice employing an exploitation strategy which reduced task complexity. Our results implicate ACCp claustrum neurons in restricting engagement during sleep and goal-directed behavior.
Identifiants
pubmed: 38926345
doi: 10.1038/s41467-024-48829-6
pii: 10.1038/s41467-024-48829-6
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
5415Subventions
Organisme : EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council)
ID : 770951
Organisme : EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council)
ID : 864353
Organisme : Israel Science Foundation (ISF)
ID : 393/12
Organisme : Israel Science Foundation (ISF)
ID : 2341/15
Organisme : Israel Science Foundation (ISF)
ID : 590/23
Organisme : Israel Science Foundation (ISF)
ID : 1326/15
Organisme : Israel Science Foundation (ISF)
ID : 51/11
Organisme : Hebrew University | National Institute for Psychobiology in Israel, Hebrew University of Jerusalem (NIPI)
ID : 109-15-16
Informations de copyright
© 2024. The Author(s).
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