First in vitro cell co-culture experiments using laser-induced high-energy electron FLASH irradiation for the development of anti-cancer therapeutic strategies.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
27 06 2024
27 06 2024
Historique:
received:
24
01
2024
accepted:
17
06
2024
medline:
28
6
2024
pubmed:
28
6
2024
entrez:
27
6
2024
Statut:
epublish
Résumé
Radiation delivery at ultrahigh dose rates (UHDRs) has potential for use as a new anticancer therapeutic strategy. The FLASH effect induced by UHDR irradiation has been shown to maintain antitumour efficacy with a reduction in normal tissue toxicity; however, the FLASH effect has been difficult to demonstrate in vitro. The objective to demonstrate the FLASH effect in vitro is challenging, aiming to reveal a differential response between cancer and normal cells to further identify cell molecular mechanisms. New high-intensity petawatt laser-driven accelerators can deliver very high-energy electrons (VHEEs) at dose rates as high as 10
Identifiants
pubmed: 38937505
doi: 10.1038/s41598-024-65137-7
pii: 10.1038/s41598-024-65137-7
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
14866Subventions
Organisme : IFA (Institute of Atomic Physics)
ID : ELI-RO_2020_11 Project, No. 01/2020
Organisme : UEFISCDI
ID : PCE No. 8/2021
Organisme : Romanian Ministry of Education and Research
ID : LAPLAS VII No. 30N/2023
Organisme : Laserlab-Europe
ID : Grant No. 871124
Organisme : Romanian Academy
ID : No. 1/2023
Informations de copyright
© 2024. The Author(s).
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