Pan-cancer profiling of tumor-infiltrating natural killer cells through transcriptional reference mapping.
Journal
Nature immunology
ISSN: 1529-2916
Titre abrégé: Nat Immunol
Pays: United States
ID NLM: 100941354
Informations de publication
Date de publication:
02 Jul 2024
02 Jul 2024
Historique:
received:
25
10
2023
accepted:
30
05
2024
medline:
3
7
2024
pubmed:
3
7
2024
entrez:
2
7
2024
Statut:
aheadofprint
Résumé
The functional diversity of natural killer (NK) cell repertoires stems from differentiation, homeostatic, receptor-ligand interactions and adaptive-like responses to viral infections. In the present study, we generated a single-cell transcriptional reference map of healthy human blood- and tissue-derived NK cells, with temporal resolution and fate-specific expression of gene-regulatory networks defining NK cell differentiation. Transfer learning facilitated incorporation of tumor-infiltrating NK cell transcriptomes (39 datasets, 7 solid tumors, 427 patients) into the reference map to analyze tumor microenvironment (TME)-induced perturbations. Of the six functionally distinct NK cell states identified, a dysfunctional stressed CD56
Identifiants
pubmed: 38956379
doi: 10.1038/s41590-024-01884-z
pii: 10.1038/s41590-024-01884-z
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Vetenskapsrådet (Swedish Research Council)
ID : 223310
Organisme : Vetenskapsrådet (Swedish Research Council)
ID : 2021-03069
Organisme : Cancerfonden (Swedish Cancer Society)
ID : 21-1793Pj
Organisme : Cancerfonden (Swedish Cancer Society)
ID : 23-2946Pj
Organisme : Barncancerfonden (Swedish Childhood Cancer Foundation)
ID : PR2020-1059
Organisme : Norges Forskningsråd (Research Council of Norway)
ID : 275469
Organisme : Norges Forskningsråd (Research Council of Norway)
ID : 237579
Organisme : Ministry of Health and Care Services | Helse Sør-Øst RHF (Southern and Eastern Norway Regional Health Authority)
ID : 2021-073
Organisme : Ministry of Health and Care Services | Helse Sør-Øst RHF (Southern and Eastern Norway Regional Health Authority)
ID : 2024-053
Informations de copyright
© 2024. The Author(s).
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