Olli Dufva

Affiliations

Hematology Research Unit Helsinki, University of Helsinki and Department of Hematology, Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland.

Publications (17)

Data-driven characterization of molecular phenotypes across heterogeneous sample collections.

Nucleic acids research

Avec: Juha Mehtonen , Petri Pölönen , Sergei Häyrynen , Olli Dufva , Jake Lin , Thomas Liuksiala , Kirsi Granberg , Olli Lohi , Ville Hautamäki , Matti Nykter , Merja Heinäniemi

Erythroid/megakaryocytic differentiation confers BCL-XL dependency and venetoclax resistance in acute myeloid leukemia.

Blood

Avec: Heikki Kuusanmäki , Olli Dufva , Markus Vähä-Koskela , Aino-Maija Leppä , Jani Huuhtanen , Ida Vänttinen , Petra Nygren , Jay Klievink , Jonas Bouhlal , Petri Pölönen , Qi Zhang , Shady Adnan-Awad , Cristina Mancebo-Pérez , Joseph Saad , Juho Miettinen , Komal K Javarappa , Sofia Aakko , Tanja Ruokoranta , Samuli Eldfors , Merja Heinäniemi , Kim Theilgaard-Mönch , Ulla Wartiovaara-Kautto , Mikko Keränen , Kimmo Porkka , Marina Konopleva , Krister Wennerberg , Mika Kontro , Caroline A Heckman , Satu Mustjoki

Pan-cancer profiling of tumor-infiltrating natural killer cells through transcriptional reference mapping.

Nature immunology

Avec: Herman Netskar , Aline Pfefferle , Jodie P Goodridge , Ebba Sohlberg , Olli Dufva , Sarah A Teichmann , Demi Brownlie , Jakob Michaëlsson , Nicole Marquardt , Trevor Clancy , Amir Horowitz , Karl-Johan Malmberg

Integrated drug profiling and CRISPR screening identify essential pathways for CAR T-cell cytotoxicity.

Blood

Avec: Olli Dufva , Jan Koski , Pilvi Maliniemi , Aleksandr Ianevski , Jay Klievink , Judith Leitner , Petri Pölönen , Helena Hohtari , Khalid Saeed , Tiina Hannunen , Pekka Ellonen , Peter Steinberger , Matti Kankainen , Tero Aittokallio , Mikko A I Keränen , Matti Korhonen , Satu Mustjoki

RUNX1 mutations in blast-phase chronic myeloid leukemia associate with distinct phenotypes, transcriptional profiles, and drug responses.

Leukemia

Avec: Shady Adnan Awad , Olli Dufva , Aleksandr Ianevski , Bishwa Ghimire , Jan Koski , Pilvi Maliniemi , Daniel Thomson , Andreas Schreiber , Caroline A Heckman , Perttu Koskenvesa , Matti Korhonen , Kimmo Porkka , Susan Branford , Tero Aittokallio , Matti Kankainen , Satu Mustjoki

Haematologica

Avec: Heikki Kuusanmäki , Sari Kytölä , Ida Vänttinen , Tanja Ruokoranta , Amanda Ranta , Jani Huuhtanen , Minna Suvela , Alun Parsons , Annasofia Holopainen , Anu Partanen , Milla E L Kuusisto , Sirpa Koskela , Riikka Räty , Maija Itälä-Remes , Imre Västrik , Olli Dufva , Sanna Siitonen , Kimmo Porkka , Krister Wennerberg , Caroline A Heckman , Pia Ettala , Marja Pyörälä , Johanna Rimpiläinen , Timo Siitonen , Mika Kontro

Single-cell analysis of immune recognition in chronic myeloid leukemia patients following tyrosine kinase inhibitor discontinuation.

Leukemia

Avec: Jani Huuhtanen , Shady Adnan-Awad , Jason Theodoropoulos , Sofia Forstén , Rebecca Warfvinge , Olli Dufva , Jonas Bouhlal , Parashar Dhapola , Hanna Duàn , Essi Laajala , Tiina Kasanen , Jay Klievink , Mette Ilander , Taina Jaatinen , Ulla Olsson-Strömberg , Henrik Hjorth-Hansen , Andreas Burchert , Göran Karlsson , Anna Kreutzman , Harri Lähdesmäki , Satu Mustjoki

Implementing a Functional Precision Medicine Tumor Board for Acute Myeloid Leukemia.

Cancer discovery

Avec: Disha Malani , Ashwini Kumar , Oscar Brück , Mika Kontro , Bhagwan Yadav , Monica Hellesøy , Heikki Kuusanmäki , Olli Dufva , Matti Kankainen , Samuli Eldfors , Swapnil Potdar , Jani Saarela , Laura Turunen , Alun Parsons , Imre Västrik , Katja Kivinen , Janna Saarela , Riikka Räty , Minna Lehto , Maija Wolf , Bjorn Tore Gjertsen , Satu Mustjoki , Tero Aittokallio , Krister Wennerberg , Caroline A Heckman , Olli Kallioniemi , Kimmo Porkka

Genome-scale screens identify factors regulating tumor cell responses to natural killer cells.

Nature genetics

Avec: Michal Sheffer , Emily Lowry , Nicky Beelen , Minasri Borah , Suha Naffar-Abu Amara , Chris C Mader , Jennifer A Roth , Aviad Tsherniak , Samuel S Freeman , Olga Dashevsky , Sara Gandolfi , Samantha Bender , Jordan G Bryan , Cong Zhu , Li Wang , Ifrah Tariq , Govinda M Kamath , Ricardo De Matos Simoes , Eugen Dhimolea , Channing Yu , Yiguo Hu , Olli Dufva , Marios Giannakis , Vasilis Syrgkanis , Ernest Fraenkel , Todd Golub , Rizwan Romee , Satu Mustjoki , Aedin C Culhane , Lotte Wieten , Constantine S Mitsiades

Targeting Apoptosis Pathways With BCL2 and MDM2 Inhibitors in Adult B-cell Acute Lymphoblastic Leukemia.

HemaSphere

Avec: Helena Hohtari , Matti Kankainen , Shady Adnan-Awad , Bhagwan Yadav , Swapnil Potdar , Aleksandr Ianevski , Olli Dufva , Caroline Heckman , Veronika Sexl , Soili Kytölä , Satu Mustjoki , Kimmo Porkka

Single-cell functional genomics reveals determinants of sensitivity and resistance to natural killer cells in blood cancers.

Immunity

Avec: Olli Dufva , Sara Gandolfi , Jani Huuhtanen , Olga Dashevsky , Hanna Duàn , Khalid Saeed , Jay Klievink , Petra Nygren , Jonas Bouhlal , Jenni Lahtela , Anna Näätänen , Bishwa R Ghimire , Tiina Hannunen , Pekka Ellonen , Hanna Lähteenmäki , Pauliina Rumm , Jason Theodoropoulos , Essi Laajala , Jouni Härkönen , Petri Pölönen , Merja Heinäniemi , Maija Hollmén , Shizuka Yamano , Ryosuke Shirasaki , David A Barbie , Jennifer A Roth , Rizwan Romee , Michal Sheffer , Harri Lähdesmäki , Dean A Lee , Ricardo De Matos Simoes , Matti Kankainen , Constantine S Mitsiades , Satu Mustjoki

Tracing back primed resistance in cancer via sister cells.

Nature communications

Avec: Jun Dai , Shuyu Zheng , Matías M Falco , Jie Bao , Johanna Eriksson , Sanna Pikkusaari , Sofia Forstén , Jing Jiang , Wenyu Wang , Luping Gao , Fernando Perez-Villatoro , Olli Dufva , Khalid Saeed , Yinyin Wang , Ali Amiryousefi , Anniina Färkkilä , Satu Mustjoki , Liisa Kauppi , Jing Tang , Anna Vähärautio

Immunogenomic Landscape of Hematological Malignancies.

Cancer cell

Avec: Olli Dufva , Petri Pölönen , Oscar Brück , Mikko A I Keränen , Jay Klievink , Juha Mehtonen , Jani Huuhtanen , Ashwini Kumar , Disha Malani , Sanna Siitonen , Matti Kankainen , Bishwa Ghimire , Jenni Lahtela , Pirkko Mattila , Markus Vähä-Koskela , Krister Wennerberg , Kirsi Granberg , Suvi-Katri Leivonen , Leo Meriranta , Caroline Heckman , Sirpa Leppä , Matti Nykter , Olli Lohi , Merja Heinäniemi , Satu Mustjoki

Immune profiles in acute myeloid leukemia bone marrow associate with patient age, T-cell receptor clonality, and survival.

Blood advances

Avec: Oscar Brück , Olli Dufva , Helena Hohtari , Sami Blom , Riku Turkki , Mette Ilander , Panu Kovanen , Celine Pallaud , Pedro Marques Ramos , Hanna Lähteenmäki , Katja Välimäki , Mohamed El Missiry , Antonio Ribeiro , Olli Kallioniemi , Kimmo Porkka , Teijo Pellinen , Satu Mustjoki

Integrated drug profiling and CRISPR screening identify BCR::ABL1-independent vulnerabilities in chronic myeloid leukemia.

Cell reports. Medicine

Avec: Shady Adnan Awad , Olli Dufva , Jay Klievink , Ella Karjalainen , Aleksandr Ianevski , Paavo Pietarinen , Daehong Kim , Swapnil Potdar , Maija Wolf , Kourosh Lotfi , Tero Aittokallio , Krister Wennerberg , Kimmo Porkka , Satu Mustjoki

Single-cell characterization of anti-LAG-3 and anti-PD-1 combination treatment in patients with melanoma.

The Journal of clinical investigation

Avec: Jani Huuhtanen , Henna Kasanen , Katriina Peltola , Tapio Lönnberg , Virpi Glumoff , Oscar Brück , Olli Dufva , Karita Peltonen , Johanna Vikkula , Emmi Jokinen , Mette Ilander , Moon Hee Lee , Siru Mäkelä , Marta Nyakas , Bin Li , Micaela Hernberg , Petri Bono , Harri Lähdesmäki , Anna Kreutzman , Satu Mustjoki

Disruption of KLHL6 Fuels Oncogenic Antigen Receptor Signaling in B-cell Lymphoma.

Blood cancer discovery

Avec: Leo Meriranta , Selma Sorri , Kanutte Huse , Xiaonan Liu , Ivana Spasevska , Sadia Zafar , Iftekhar Chowdhury , Olli Dufva , Eerika Sahlberg , Luka Tandaric , Marja-Liisa Karjalainen-Lindsberg , Marko Hyytiainen , Markku Varjosalo , June H Myklebust , Sirpa Leppa

Réseau de co-auteurs

Satu Mustjoki 13 collaborations

Kimmo Porkka 7 collaborations

Jani Huuhtanen 6 collaborations

Jay Klievink 6 collaborations

Matti Kankainen 6 collaborations

Petri Pölönen 5 collaborations

Krister Wennerberg 5 collaborations

Merja Heinäniemi 4 collaborations

Caroline A Heckman 4 collaborations

Aleksandr Ianevski 4 collaborations

Tero Aittokallio 4 collaborations

Oscar Brück 4 collaborations

Heikki Kuusanmäki 3 collaborations

Jonas Bouhlal 3 collaborations

Shady Adnan-Awad 3 collaborations

Mika Kontro 3 collaborations

Helena Hohtari 3 collaborations

Khalid Saeed 3 collaborations

Mette Ilander 3 collaborations

Harri Lähdesmäki 3 collaborations

Swapnil Potdar 3 collaborations

Juha Mehtonen 2 collaborations

Kirsi Granberg 2 collaborations

Olli Lohi 2 collaborations

Matti Nykter 2 collaborations

Markus Vähä-Koskela 2 collaborations

Ida Vänttinen 2 collaborations

Petra Nygren 2 collaborations

Tanja Ruokoranta 2 collaborations

Samuli Eldfors 2 collaborations

Jan Koski 2 collaborations

Pilvi Maliniemi 2 collaborations

Tiina Hannunen 2 collaborations

Pekka Ellonen 2 collaborations

Mikko A I Keränen 2 collaborations

Matti Korhonen 2 collaborations

Shady Adnan Awad 2 collaborations

Bishwa Ghimire 2 collaborations

Alun Parsons 2 collaborations

Riikka Räty 2 collaborations

Imre Västrik 2 collaborations

Sanna Siitonen 2 collaborations

Jason Theodoropoulos 2 collaborations

Sofia Forstén 2 collaborations

Hanna Duàn 2 collaborations

Essi Laajala 2 collaborations

Anna Kreutzman 2 collaborations

Disha Malani 2 collaborations

Ashwini Kumar 2 collaborations

Bhagwan Yadav 2 collaborations

Maija Wolf 2 collaborations

Olli Kallioniemi 2 collaborations

Michal Sheffer 2 collaborations

Jennifer A Roth 2 collaborations

Olga Dashevsky 2 collaborations

Sara Gandolfi 2 collaborations

Ricardo De Matos Simoes 2 collaborations

Rizwan Romee 2 collaborations

Constantine S Mitsiades 2 collaborations

Caroline Heckman 2 collaborations

Jenni Lahtela 2 collaborations

Hanna Lähteenmäki 2 collaborations

Leo Meriranta 2 collaborations

Sergei Häyrynen 1 collaboration

Jake Lin 1 collaboration

Thomas Liuksiala 1 collaboration

Ville Hautamäki 1 collaboration

Aino-Maija Leppä 1 collaboration

Qi Zhang 1 collaboration

Cristina Mancebo-Pérez 1 collaboration

Joseph Saad 1 collaboration

Juho Miettinen 1 collaboration

Komal K Javarappa 1 collaboration

Sofia Aakko 1 collaboration

Kim Theilgaard-Mönch 1 collaboration

Ulla Wartiovaara-Kautto 1 collaboration

Mikko Keränen 1 collaboration

Marina Konopleva 1 collaboration

Herman Netskar 1 collaboration

Aline Pfefferle 1 collaboration

Jodie P Goodridge 1 collaboration

Ebba Sohlberg 1 collaboration

Sarah A Teichmann 1 collaboration

Demi Brownlie 1 collaboration

Jakob Michaëlsson 1 collaboration

Nicole Marquardt 1 collaboration

Trevor Clancy 1 collaboration

Amir Horowitz 1 collaboration

Karl-Johan Malmberg 1 collaboration

Judith Leitner 1 collaboration

Peter Steinberger 1 collaboration

Daniel Thomson 1 collaboration

Andreas Schreiber 1 collaboration

Perttu Koskenvesa 1 collaboration

Susan Branford 1 collaboration

Sari Kytölä 1 collaboration

Amanda Ranta 1 collaboration

Minna Suvela 1 collaboration

Annasofia Holopainen 1 collaboration

Anu Partanen 1 collaboration

Milla E L Kuusisto 1 collaboration

Sirpa Koskela 1 collaboration

Maija Itälä-Remes 1 collaboration

Pia Ettala 1 collaboration

Marja Pyörälä 1 collaboration

Johanna Rimpiläinen 1 collaboration

Timo Siitonen 1 collaboration

Rebecca Warfvinge 1 collaboration

Parashar Dhapola 1 collaboration

Tiina Kasanen 1 collaboration

Taina Jaatinen 1 collaboration

Ulla Olsson-Strömberg 1 collaboration

Henrik Hjorth-Hansen 1 collaboration

Andreas Burchert 1 collaboration

Göran Karlsson 1 collaboration

Monica Hellesøy 1 collaboration

Jani Saarela 1 collaboration

Laura Turunen 1 collaboration

Katja Kivinen 1 collaboration

Janna Saarela 1 collaboration

Minna Lehto 1 collaboration

Bjorn Tore Gjertsen 1 collaboration

Emily Lowry 1 collaboration

Nicky Beelen 1 collaboration

Minasri Borah 1 collaboration

Suha Naffar-Abu Amara 1 collaboration

Chris C Mader 1 collaboration

Aviad Tsherniak 1 collaboration

Samuel S Freeman 1 collaboration

Samantha Bender 1 collaboration

Jordan G Bryan 1 collaboration

Cong Zhu 1 collaboration

Li Wang 1 collaboration

Ifrah Tariq 1 collaboration

Govinda M Kamath 1 collaboration

Eugen Dhimolea 1 collaboration

Channing Yu 1 collaboration

Yiguo Hu 1 collaboration

Marios Giannakis 1 collaboration

Vasilis Syrgkanis 1 collaboration

Ernest Fraenkel 1 collaboration

Todd Golub 1 collaboration

Aedin C Culhane 1 collaboration

Lotte Wieten 1 collaboration

Veronika Sexl 1 collaboration

Soili Kytölä 1 collaboration

Anna Näätänen 1 collaboration

Bishwa R Ghimire 1 collaboration

Pauliina Rumm 1 collaboration

Jouni Härkönen 1 collaboration

Maija Hollmén 1 collaboration

Shizuka Yamano 1 collaboration

Ryosuke Shirasaki 1 collaboration

David A Barbie 1 collaboration

Dean A Lee 1 collaboration

Jun Dai 1 collaboration

Shuyu Zheng 1 collaboration

Matías M Falco 1 collaboration

Jie Bao 1 collaboration

Johanna Eriksson 1 collaboration

Sanna Pikkusaari 1 collaboration

Jing Jiang 1 collaboration

Wenyu Wang 1 collaboration

Luping Gao 1 collaboration

Fernando Perez-Villatoro 1 collaboration

Yinyin Wang 1 collaboration

Ali Amiryousefi 1 collaboration

Anniina Färkkilä 1 collaboration

Liisa Kauppi 1 collaboration

Jing Tang 1 collaboration

Anna Vähärautio 1 collaboration

Pirkko Mattila 1 collaboration

Suvi-Katri Leivonen 1 collaboration

Sirpa Leppä 1 collaboration

Sami Blom 1 collaboration

Riku Turkki 1 collaboration

Panu Kovanen 1 collaboration

Celine Pallaud 1 collaboration

Pedro Marques Ramos 1 collaboration

Katja Välimäki 1 collaboration

Mohamed El Missiry 1 collaboration

Antonio Ribeiro 1 collaboration

Teijo Pellinen 1 collaboration

Ella Karjalainen 1 collaboration

Paavo Pietarinen 1 collaboration

Daehong Kim 1 collaboration

Kourosh Lotfi 1 collaboration

Henna Kasanen 1 collaboration

Katriina Peltola 1 collaboration

Tapio Lönnberg 1 collaboration

Virpi Glumoff 1 collaboration

Karita Peltonen 1 collaboration

Johanna Vikkula 1 collaboration

Emmi Jokinen 1 collaboration

Moon Hee Lee 1 collaboration

Siru Mäkelä 1 collaboration

Marta Nyakas 1 collaboration

Bin Li 1 collaboration

Micaela Hernberg 1 collaboration

Petri Bono 1 collaboration

Selma Sorri 1 collaboration

Kanutte Huse 1 collaboration

Xiaonan Liu 1 collaboration

Ivana Spasevska 1 collaboration

Sadia Zafar 1 collaboration

Iftekhar Chowdhury 1 collaboration

Eerika Sahlberg 1 collaboration

Luka Tandaric 1 collaboration

Marja-Liisa Karjalainen-Lindsberg 1 collaboration

Marko Hyytiainen 1 collaboration

Markku Varjosalo 1 collaboration

June H Myklebust 1 collaboration

Sirpa Leppa 1 collaboration