The features analysis of hemoglobin expression on visual information transmission pathway in early stage of Alzheimer's disease.
Alzheimer’s disease
Hemoglobin
Visual information transmission pathway
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
08 Jul 2024
08 Jul 2024
Historique:
received:
06
03
2024
accepted:
05
06
2024
medline:
8
7
2024
pubmed:
8
7
2024
entrez:
7
7
2024
Statut:
epublish
Résumé
Alzheimer's disease (AD) is a neurodegenerative disorder characterized primarily by cognitive impairment. The motivation of this paper is to explore the impact of the visual information transmission pathway (V-H pathway) on AD, and the following feature were observed: Hemoglobin expression on the V-H pathway becomes dysregulated as AD occurs so as to the pathway becomes dysfunctional. According to the feature, the following conclusion was proposed: As AD occurs, abnormal tau proteins penetrate bloodstream and arrive at the brain regions of the pathway. Then the tau proteins or other toxic substances attack hemoglobin molecules. Under the attack, hemoglobin expression becomes more dysregulated. The dysfunction of V-H pathway has an impact on early symptoms of AD, such as spatial recognition disorder and face recognition disorder.
Identifiants
pubmed: 38972885
doi: 10.1038/s41598-024-64099-0
pii: 10.1038/s41598-024-64099-0
doi:
Substances chimiques
Hemoglobins
0
tau Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
15636Informations de copyright
© 2024. The Author(s).
Références
Lane, C. A., Hardy, J. & Schott, J. M. Alzheimer’s disease. Eur. J. Neurol. 25(1), 59–70 (2018).
pubmed: 28872215
Weller, J., Budson, A. Current understanding of Alzheimer’s disease diagnosis and treatment. F1000Research. 7 (2018).
Yap, L. E., Hunt, J. E. & Turner, R. S. Aging as a target for the prevention and treatment of Alzheimer’s disease. Front. Neurol. 15, 1376104 (2024).
pubmed: 38645748
pmcid: 11027067
Sehar, U., Kopel, J. & Reddy, P. H. Alzheimer’s disease and its related dementias in US Native Americans: A major public health concern[J]. Ageing Res. Rev. 90, 102027 (2023).
pubmed: 37544432
Hodson, R. Alzheimer’s disease[J]. Nature 559(7715), S1–S1 (2018).
pubmed: 30046078
Moser, I. Making Alzheimer’s disease matter. Enacting, interfering and doing politics of nature. Geoforum. 39(1), 98–110 (2008).
(2018). 2018 Alzheimer's disease facts and figures. Alzheimer's & Dementia. 14(3), 367–429. ISSN 1552-5260. https://doi.org/10.1016/j.jalz.2018.02.001 .
Dubois, B. et al. Timely diagnosis for Alzheimer’s disease: A literature review on benefits and challenges[J]. J. Alzheimer’s Disease 49(3), 617–631 (2016).
Aminoff, E. M., Kveraga, K. & Bar, M. The role of the parahippocampal cortex in cognition[J]. Trends Cognit. Sci. 17(8), 379–390 (2013).
Lisman, J. et al. Viewpoints: How the hippocampus contributes to memory, navigation and cognition[J]. Nat. Neurosci. 20(11), 1434–1447 (2017).
pubmed: 29073641
pmcid: 5943637
Mullally, S. L. & Maguire, E. A. A new role for the parahippocampal cortex in representing space[J]. J. Neurosci. 31(20), 7441–7449 (2011).
pubmed: 21593327
pmcid: 3101571
Geva-Sagiv, M. et al. Proximity to boundaries reveals spatial context representation in human hippocampal CA1[J]. Neuropsychologia 189, 108656 (2023).
pubmed: 37541615
Lee, S. M. et al. Goal-directed interaction of stimulus and task demand in the parahippocampal region[J]. Hippocampus 31(7), 717–736 (2021).
pubmed: 33394547
pmcid: 8359334
Slotnick, S. D. The hippocampus and long-term memory[J]. Cognit. Neurosci. 13(3–4), 113–114 (2022).
Voss, M. W. et al. Exercise and hippocampal memory systems[J]. Trends Cognit. Sci. 23(4), 318–333 (2019).
Donato, F. et al. The ontogeny of hippocampus-dependent memories[J]. J. Neurosci. 41(5), 920–926 (2021).
pubmed: 33328296
pmcid: 7880290
Wade, A.R., Brewer, A.A., Rieger, J.W., et al. (2002) Functional measurements of human ventral occipital cortex: Retinotopy and colour[J]. Philos. Trans. R. Soc. Lond. Series B Biol. Sci. 357(1424), 963–973.
Dupont, P. et al. The kinetic occipital region in human visual cortex[J]. Cerebral Cortex (New York, NY). 7(3), 283–292 (1997).
Mazo, C., Baeta, M. & Petreanu, L. Auditory cortex conveys non-topographic sound localization signals to visual cortex[J]. Nat. Commun. 15(1), 3116 (2024).
pubmed: 38600132
pmcid: 11006897
Lu, S. T. et al. Seeing faces activates three separate areas outside the occipital visual cortex in man[J]. Neuroscience 43(2–3), 287–290 (1991).
pubmed: 1922773
Davey, J. et al. Exploring the role of the posterior middle temporal gyrus in semantic cognition: Integration of anterior temporal lobe with executive processes[J]. Neuroimage 137, 165–177 (2016).
pubmed: 27236083
Ren, J. et al. The function of the hippocampus and middle temporal gyrus in forming new associations and concepts during the processing of novelty and usefulness features in creative designs[J]. Neuroimage 214, 116751 (2020).
pubmed: 32194284
Wei, T. et al. Predicting conceptual processing capacity from spontaneous neuronal activity of the left middle temporal gyrus[J]. J. Neurosci. 32(2), 481–489 (2012).
pubmed: 22238084
pmcid: 6621087
Buckley, M. J., Gaffan, D. & Murray, E. A. Functional double dissociation between two inferior temporal cortical areas: perirhinal cortex versus middle temporal gyrus[J]. J. Neurophysiol. 77(2), 587–598 (1997).
pubmed: 9065832
Onitsuka, T. et al. Middle and inferior temporal gyrus gray matter volume abnormalities in chronic schizophrenia: an MRI study[J]. Am. J. Psychiatry 161(9), 1603–1611 (2004).
pubmed: 15337650
pmcid: 2793337
Van Hoesen, G. W. The parahippocampal gyrus: New observations regarding its cortical connections in the monkey[J]. Trends Neurosci. 5, 345–350 (1982).
Van Hoesen, G. W. et al. The parahippocampal gyrus in Alzheimer’s disease: Clinical and preclinical neuroanatomical correlates[J]. Ann. N.Y. Acad. Sci. 911(1), 254–274 (2000).
pubmed: 10911879
Powell, H. W. R. et al. Noninvasive in vivo demonstration of the connections of the human parahippocampal gyrus[J]. Neuroimage 22(2), 740–747 (2004).
pubmed: 15193602
Rolls, E. T. A theory of hippocampal function in memory[J]. Hippocampus 6(6), 601–620 (1996).
pubmed: 9034849
Opitz, B. Memory function and the hippocampus[J]. Hippocampus Clin. Neurosci. 34, 51–59 (2014).
Eichenbaum, H., Otto, T. & Cohen, N. J. The hippocampus—What does it do?[J]. Behav. Neural Biol. 57(1), 2–36 (1992).
pubmed: 1567331
Leuner, B. & Gould, E. Structural plasticity and hippocampal function[J]. Annu. Rev. Psychol. 61, 111–140 (2010).
pubmed: 19575621
pmcid: 3012424
Kaas, J. H. & Baldwin, M. K. L. The evolution of the pulvinar complex in primates and its role in the dorsal and ventral streams of cortical processing[J]. Vision 4(1), 3 (2019).
pubmed: 31905909
pmcid: 7157193
Choi, S. H. et al. Proposal for human visual pathway in the extrastriate cortex by fiber tracking method using diffusion-weighted MRI[J]. Neuroimage 220, 117145 (2020).
pubmed: 32650055
Stepniewska, I., Kaas, J.H. The dorsal stream of visual processing and action‐specific domains in parietal and frontal cortex in primates[J]. J. Comp. Neurol. (2023).
Ayzenberg, V. & Behrmann, M. Does the brain’s ventral visual pathway compute object shape?[J]. Trends Cognit. Sci. 26(12), 1119–1132 (2022).
Cramer, P. Organization and regulation of gene transcription[J]. Nature 573(7772), 45–54 (2019).
pubmed: 31462772
West, A. G. & Fraser, P. Remote control of gene transcription[J]. Hum. Mol. Genet. 14(suppl_1), R101–R111 (2005).
pubmed: 15809261
Lemon, B. & Tjian, R. Orchestrated response: A symphony of transcription factors for gene control[J]. Genes Develop. 14(20), 2551–2569 (2000).
pubmed: 11040209
Hsia, C. C. W. Respiratory function of hemoglobin[J]. N. Engl. J. Med. 338(4), 239–248 (1998).
pubmed: 9435331
Faggiano, S. et al. From hemoglobin allostery to hemoglobin-based oxygen carriers[J]. Mol. Aspects Med. 84, 101050 (2022).
pubmed: 34776270
Perutz, M. F. Mechanisms regulating the reactions of human hemoglobin with oxygen and carbon monoxide[J]. Annu. Rev. Physiol. 52(1), 1–26 (1990).
pubmed: 2184753
Giardina, B. Hemoglobin: Multiple molecular interactions and multiple functions. An example of energy optimization and global molecular organization[J]. Mol. Aspects Med. 84, 101040 (2022).
pubmed: 34686369
Parashar, A. et al. Hemoglobin catalyzes ATP-synthesis in human erythrocytes: A murburn model[J]. J. Biomol. Struct. Dynam. 40(19), 8783–8795 (2022).
Ahmed M H, Ghatge M S, Safo M K. Hemoglobin: structure, function and allostery[J]. Vertebrate and invertebrate respiratory proteins, lipoproteins and other body fluid proteins. 2020: 345–382.
Fehsel, K. Why is iron deficiency/anemia linked to Alzheimer’s disease and its comorbidities, and how is it prevented?[J]. Biomedicines 11(9), 2421 (2023).
pubmed: 37760862
pmcid: 10526115
Kim, J. W. et al. Blood hemoglobin, in-vivo Alzheimer pathologies, and cognitive impairment: A cross-sectional study[J]. Front. Aging Neurosci. 13, 625511 (2021).
pubmed: 33716712
pmcid: 7943867
Lee, J. & Hyun, D. H. The interplay between intracellular iron homeostasis and neuroinflammation in neurodegenerative diseases[J]. Antioxidants 12(4), 918 (2023).
pubmed: 37107292
pmcid: 10135822
Faux, N. G. et al. An anemia of Alzheimer’s disease[J]. Mol. Psychiatry 19(11), 1227–1234 (2014).
pubmed: 24419041
Xiong, J., Pang, X., Yang, L., et al. The coherence between PSMC6 and α-ring in the 26S proteasome is associated with Alzheimer's disease[J]. Front. Mol. Neurosci. 16, 1330853.
Yang, X. et al. The relationship between protein modified folding molecular network and Alzheimer’s disease pathogenesis based on BAG2-HSC70-STUB1-MAPT expression patterns analysis[J]. Front. Aging Neurosci. 15, 1090400 (2023).
pubmed: 37251806
pmcid: 10213342
Yang, L. et al. An exploration of the coherent effects between METTL3 and NDUFA10 on Alzheimer’s disease[J]. Int. J. Mol. Sci. 24(12), 10111 (2023).
pubmed: 37373264
pmcid: 10299292
Guo, W. et al. Corrigendum: Exploring the interaction between T-cell antigen receptor-related genes and MAPT or ACHE using integrated bioinformatics analysis[J]. Front. Neurol. 14, 1204487 (2023).
pubmed: 37181562
pmcid: 10169739
Zhang, Q. et al. Bioinformatics-based study reveals that AP2M1 is regulated by the circRNA-miRNA-mRNA interaction network and affects Alzheimer’s disease[J]. Front. Genet. 13, 1049786 (2022).
pubmed: 36468008
pmcid: 9716081
Zhang, Q. et al. Preliminary exploration of the co-regulation of Alzheimer’s disease pathogenic genes by microRNAs and transcription factors[J]. Front. Aging Neurosci. 14, 1069606 (2022).
pubmed: 36561136
pmcid: 9764863
David L. Nelson, Michael M. Cox. Lehninger Principles of Biochemistry (Seventh Edition), ISBN-13: 978-1-4641-2611-6, ©2017, 2013, 2008, 2005 by W. H. Freeman and Company (Biochemical books)
Barrett, T. et al. NCBI GEO: archive forfunctional genomics data sets: update. Nucleic Acids Res. 41(database issue), D991-5 (2013).
pubmed: 23193258
Edgar, R., Domrachev, M. & Lash, A. E. Gene Expression Omnibus: NCBI gene expression and hybridization array data repository [J]. Nucleic Acids Res. 30(1), 207–210 (2002).
pubmed: 11752295
pmcid: 99122
Love, M. I., Huber, W. & Anders, S. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2[J]. Genome Biol. 15(12), 1–21 (2014).
Ritchie, M. E. et al. limma powers differential expression analyses for RNA-sequencing and microarray studies[J]. Nucleic Acids Res. 43(7), e47 (2015).
pubmed: 25605792
pmcid: 4402510
Liu, G., Wong, L. & Chua, H. N. Complex discovery from weighted PPI networks[J]. Bioinformatics 25(15), 1891–1897 (2009).
pubmed: 19435747