Liver fibrosis as a predictor of liver failure and outcome following ALPPS among patients with primary liver cancer.
Humans
Male
Female
Liver Cirrhosis
/ surgery
Liver Neoplasms
/ surgery
Middle Aged
Liver Failure
/ etiology
Hepatectomy
/ adverse effects
Aged
Prognosis
Postoperative Complications
/ etiology
Carcinoma, Hepatocellular
/ surgery
Portal Vein
/ pathology
Cholangiocarcinoma
/ surgery
Adult
Liver Regeneration
Risk Factors
Retrospective Studies
Treatment Outcome
Ligation
ALPPS
Liver cancer
Liver failure
Liver fibrosis
Liver regeneration
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
09 Jul 2024
09 Jul 2024
Historique:
received:
18
03
2024
accepted:
25
06
2024
medline:
10
7
2024
pubmed:
10
7
2024
entrez:
9
7
2024
Statut:
epublish
Résumé
The influence of liver fibrosis on the rate of liver regeneration and complications following ALPPS has yet to be fully understood. This study aimed to scrutinize the effects of liver fibrosis on the postoperative complications, and prognosis subsequent to ALPPS. Clinical data were collected from patients with primary liver cancer who underwent ALPPS at Peking Union Medical College Hospital between May 2014 and October 2022. The degree of liver fibrosis was assessed using haematoxylin-eosin staining and Sirius red staining. This study encompassed thirty patients who underwent ALPPS for primary liver cancer, and there were 23 patients with hepatocellular carcinoma, 5 with cholangiocarcinoma, and 2 with combined hepatocellular-cholangiocarcinoma. The impact of severe liver fibrosis on the rate of liver regeneration was not statistically significant (P = 0.892). All patients with severe complications belonged to the severe liver fibrosis group. Severe liver fibrosis exhibited a significant association with 90 days mortality (P = 0.014) and overall survival (P = 0.012). Severe liver fibrosis emerges as a crucial risk factor for liver failure and perioperative mortality following the second step of ALPPS. Preoperative liver function impairment is an important predictive factor for postoperative liver failure.
Identifiants
pubmed: 38982109
doi: 10.1038/s41598-024-65924-2
pii: 10.1038/s41598-024-65924-2
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
15827Subventions
Organisme : National High Level Hospital Clinical Research Funding
ID : 2022-PUMCH-C-049
Organisme : National High Level Hospital Clinical Research Funding
ID : 2022-PUMCH-C-049
Organisme : National High Level Hospital Clinical Research Funding
ID : 2022-PUMCH-C-049
Organisme : National High Level Hospital Clinical Research Funding
ID : 2022-PUMCH-C-049
Organisme : National High Level Hospital Clinical Research Funding
ID : 2022-PUMCH-C-049
Organisme : National High Level Hospital Clinical Research Funding
ID : 2022-PUMCH-C-049
Organisme : National High Level Hospital Clinical Research Funding
ID : 2022-PUMCH-C-049
Organisme : National High Level Hospital Clinical Research Funding
ID : 2022-PUMCH-C-049
Organisme : National High Level Hospital Clinical Research Funding
ID : 2022-PUMCH-C-049
Organisme : National High Level Hospital Clinical Research Funding
ID : 2022-PUMCH-C-049
Organisme : National High Level Hospital Clinical Research Funding
ID : 2022-PUMCH-C-049
Informations de copyright
© 2024. The Author(s).
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