Lactate and base excess (BE) as markers of hypoperfusion and mortality in traumatic hemorrhagic shock in patients undergoing Damage Control: a historical cohort.


Journal

Revista do Colegio Brasileiro de Cirurgioes
ISSN: 1809-4546
Titre abrégé: Rev Col Bras Cir
Pays: Brazil
ID NLM: 7809515

Informations de publication

Date de publication:
2024
Historique:
received: 27 11 2023
accepted: 11 03 2024
medline: 10 7 2024
pubmed: 10 7 2024
entrez: 10 7 2024
Statut: epublish

Résumé

hemorrhagic shock is a significant cause of trauma-related deaths in Brazil and worldwide. This study aims to compare BE and lactate values at ICU admission and twenty-four hours after in identifying tissue hypoperfusion and mortality. examines a historical cohort of trauma patients over eitheen years old submittet to damage control resuscitation approch upon hospital admission and were then admitted to the ICU. We collected and analyzed ISS, mechanism and type of trauma, need for renal replacement therapy, massive transfusion. BE, lactate, pH, bicarbonate at ICU admission and twenty-four hours later, and mortality data. The patients were grouped based on their BE values (≥-6 and <-6mmol/L), which were previously identified in the literature as predictors of severity. They were subsequently redivided using the most accurate values found in this sample. In addition to performing multivariate binary logistic regression. The data were compared using several statistical tests due to diversity and according to the indication for each variable. there were significant changes in perfusion upon admission to the Intensive Care Unit. BE is a statistically significant value for predicting mortality, as determined by using values from previous literature and from this study. the results demonstrate the importance of monitoring BE levels in the prediction of ICU mortality. BE proves to be a valuable bedside marker with quick results and wide availability.

Identifiants

pubmed: 38985036
pii: S0100-69912024000100210
doi: 10.1590/0100-6991e-20243699-en
pii:
doi:

Substances chimiques

Lactic Acid 33X04XA5AT
Biomarkers 0

Types de publication

Journal Article

Langues

eng por

Sous-ensembles de citation

IM

Pagination

e20243699

Auteurs

Fernanda Baeumle Reese (FB)

- Universidade Federal do Paraná, Programa de Mestrado - Curitiba - PR - Brasil.

Flavia Castanho Hubert (FC)

- Universidade Federal do Paraná, Complexo Hospital de Clínicas da Universidade Federal do Paraná - Curitiba - PR - Brasil.

Mariana Bruinje Cosentino (MB)

- Hospital do Trabalhador, Hospital do Trabalhador - Curitiba - PR - Brasil.

Mirella Cristine DE Oliveira (MC)

- Pontifícia Universidade Católica do Paraná (PUC-PR), Centro de estudos e pesquisa em Terapia Intensiva (CEPETI) - Curitiba - PR - Brasil.

Álvaro Réa Neto (Á)

- Universidade Federal do Paraná, Departamento de Clínica Médica - Curitiba - PR - Brasil.

Rafaella Stradiotto Bernardelli (RS)

- Pontifícia Universidade Católica do Paraná (PUC-PR), Centro de estudos e pesquisa em Terapia Intensiva (CEPETI) - Curitiba - PR - Brasil.

Jorge Eduardo Matias (JE)

- Universidade Federal do Paraná, Programa de Mestrado - Curitiba - PR - Brasil.

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Classifications MeSH