A mixed meal tolerance test predicts onset of type 2 diabetes in Southwestern Indigenous adults.
Journal
Nutrition & diabetes
ISSN: 2044-4052
Titre abrégé: Nutr Diabetes
Pays: England
ID NLM: 101566341
Informations de publication
Date de publication:
10 Jul 2024
10 Jul 2024
Historique:
received:
05
05
2023
accepted:
23
02
2024
revised:
05
01
2024
medline:
11
7
2024
pubmed:
11
7
2024
entrez:
10
7
2024
Statut:
epublish
Résumé
To identify predictors of incident type 2 diabetes using a mixed meal tolerance test (MMTT). Adult Indigenous Americans without diabetes (n = 501) from a longitudinal cohort underwent at baseline a 4-h MMTT, measures of body composition, an oral glucose tolerance test, an intravenous glucose tolerance test for acute insulin response (AIR), and a hyperinsulinemic-euglycemic clamp for insulin action (M). Plasma glucose responses from the MMTT were quantified by the total and incremental area under the curve (AUC/iAUC). At follow-up (median time 9.6 [inter-quartile range: 5.6-13.5] years), 169 participants were diagnosed with diabetes. Unadjusted Cox proportional hazards models, glucose AUC Glucose responses to a mixed meal predicted the development of type 2 diabetes. This indicates that a mixed nutritional challenge provides important information on disease risk. ClinicalTrials.gov identifier : NCT00340132, NCT00339482.
Sections du résumé
BACKGROUND/OBJECTIVE
OBJECTIVE
To identify predictors of incident type 2 diabetes using a mixed meal tolerance test (MMTT).
METHODS
METHODS
Adult Indigenous Americans without diabetes (n = 501) from a longitudinal cohort underwent at baseline a 4-h MMTT, measures of body composition, an oral glucose tolerance test, an intravenous glucose tolerance test for acute insulin response (AIR), and a hyperinsulinemic-euglycemic clamp for insulin action (M). Plasma glucose responses from the MMTT were quantified by the total and incremental area under the curve (AUC/iAUC).
RESULTS
RESULTS
At follow-up (median time 9.6 [inter-quartile range: 5.6-13.5] years), 169 participants were diagnosed with diabetes. Unadjusted Cox proportional hazards models, glucose AUC
CONCLUSIONS
CONCLUSIONS
Glucose responses to a mixed meal predicted the development of type 2 diabetes. This indicates that a mixed nutritional challenge provides important information on disease risk.
CLINICAL TRIAL REGISTRY
BACKGROUND
ClinicalTrials.gov identifier : NCT00340132, NCT00339482.
Identifiants
pubmed: 38987291
doi: 10.1038/s41387-024-00269-3
pii: 10.1038/s41387-024-00269-3
doi:
Substances chimiques
Blood Glucose
0
Insulin
0
Banques de données
ClinicalTrials.gov
['NCT00339482', 'NCT00340132']
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
50Informations de copyright
© 2024. The Author(s).
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