Right ventricular diastolic adaptation to pressure overload in different rat strains.
Animals
Male
Rats
Diastole
/ physiology
Ventricular Function, Right
/ physiology
Adaptation, Physiological
/ physiology
Rats, Sprague-Dawley
Rats, Wistar
Ventricular Dysfunction, Right
/ physiopathology
Rats, Inbred F344
Hypertension, Pulmonary
/ physiopathology
Heart Ventricles
/ physiopathology
Species Specificity
diastolic dysfunction
pulmonary trunk banding
rat strains
right ventricular failure
Journal
Physiological reports
ISSN: 2051-817X
Titre abrégé: Physiol Rep
Pays: United States
ID NLM: 101607800
Informations de publication
Date de publication:
Jul 2024
Jul 2024
Historique:
revised:
13
06
2024
received:
05
03
2024
accepted:
23
06
2024
medline:
12
7
2024
pubmed:
12
7
2024
entrez:
12
7
2024
Statut:
ppublish
Résumé
Different rat strains are used in various animal models of pulmonary hypertension and right ventricular (RV) failure. No systematic assessment has been made to test differences in RV response to pressure overload between rat strains. We compared RV adaptation to pulmonary trunk banding (PTB) in Wistar (W), Sprague Dawley (SD), and Fischer344 (F) rats by hemodynamic profiling focusing on diastolic function. Age-matched male rat weanlings were randomized to sham surgery (W-sham, n = 5; SD-sham, n = 4; F-sham, n = 4) or PTB (W-PTB, n = 8; SD-PTB, n = 8; F-PTB, n = 8). RV function was evaluated after 5 weeks by echocardiography, cardiac MRI, and invasive pressure-volume measurements. PTB caused RV failure and increased RV systolic pressures four-fold in all three PTB groups compared with sham. W- and SD-PTB had a 2.4-fold increase in RV end-systolic volume index compared with sham, while F-PTB rats were less affected. Diastolic and right atrial impairment were evident by increased RV end-diastolic elastance, filling pressure, and E/e' in PTB rats compared with sham, again F-PTB the least affected. In conclusions, PTB caused RV failure with signs of diastolic dysfunction. Despite a similar increase in RV systolic pressure, F-PTB rats showed less RV dilatation and a more preserved diastolic function compared with W- and SD-PTB.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e16132Subventions
Organisme : Hjerteforeningen (Heart Foundation)
ID : 20-R140-A9671-22167
Organisme : The Danish Medical Research Grant
ID : 2017-1064/96
Organisme : A.P. Moeller Fonden
ID : 20-L-0184
Organisme : Helga og Peter Kornings Fond (Helga and Peter Korning's Fund)
ID : DC472123-004-lek
Organisme : Soester og Verner Lipperts Fond
ID : 25/11-2021
Organisme : Snedkermester Sophus Jacobsen og Hustru Astrid Jacobsens Fond
ID : J167/1
Organisme : The Netherlands Cardiovascular Research Initiative
ID : CVON-2018-29
Organisme : The Netherlands Cardiovascular Research Initiative
ID : CVON-2017-10
Organisme : The Netherlands organization for scientific research
ID : NWO-VIDI: 917.18.338
Organisme : The Dutch Heart Foundation dekker senior postdoc grant
ID : 2018t059
Informations de copyright
© 2024 The Author(s). Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.
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