The Nitrofuran-Warhead-Equipped Spirocyclic Azetidines Show Excellent Activity against

Mycobacterium tuberculosis / drug effects Antitubercular Agents / pharmacology Microbial Sensitivity Tests Azetidines / chemistry Nitrofurans / pharmacology Spiro Compounds / chemistry Structure-Activity Relationship Molecular Structure
antimycobacterial activity deazaflavin-dependent nitroreductase induced fit docking nitrofurans spiroazetidines tuberculosis

Journal

Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009

Informations de publication

Date de publication:
27 Jun 2024
Historique:
received: 20 05 2024
revised: 20 06 2024
accepted: 25 06 2024
medline: 13 7 2024
pubmed: 13 7 2024
entrez: 13 7 2024
Statut: epublish

Résumé

A series of 21 new 7'H-spiro[azetidine-3,5'-furo [3,4-d]pyrimidine]s substituted at the pyrimidine ring second position were synthesized. The compounds showed high antibacterial in vitro activity against

Identifiants

DOI: 10.3390/molecules29133071 PMID: 38999023
pubmed: 38999023
pii: molecules29133071
doi: 10.3390/molecules29133071
pii:
doi:

Substances chimiques

Antitubercular Agents 0
Azetidines 0
Nitrofurans 0
Spiro Compounds 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Ministry of Health of the Russian Federation
ID : 121112600145-2

Déclaration de conflit d'intérêts

The authors declare no conflicts of interest.

Auteurs

Kristina Komarova (K)

Lomonosov Institute of Fine Chemical Technologies, MIREA-Russian Technological University, 119454 Moscow, Russia.

Lyubov Vinogradova (L)

Lomonosov Institute of Fine Chemical Technologies, MIREA-Russian Technological University, 119454 Moscow, Russia.

Alexey Lukin (A)

Lomonosov Institute of Fine Chemical Technologies, MIREA-Russian Technological University, 119454 Moscow, Russia.
ORCID: 0000-0001-6162-4851

Maxim Zhuravlev (M)

Lomonosov Institute of Fine Chemical Technologies, MIREA-Russian Technological University, 119454 Moscow, Russia.

Dmitry Deniskin (D)

Lomonosov Institute of Fine Chemical Technologies, MIREA-Russian Technological University, 119454 Moscow, Russia.

Mikhail Chudinov (M)

Lomonosov Institute of Fine Chemical Technologies, MIREA-Russian Technological University, 119454 Moscow, Russia.
ORCID: 0000-0001-9735-9690

Maxim Gureev (M)

Institute of Cytology, Russian Academy of Sciences, Tikhoretsky Ave 4, 194064 Saint Petersburg, Russia.
ORCID: 0000-0002-0385-922X

Marine Dogonadze (M)

Saint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Healthcare of the Russian Federation, 191036 Saint Petersburg, Russia.

Natalia Zabolotnykh (N)

Saint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Healthcare of the Russian Federation, 191036 Saint Petersburg, Russia.

Tatiana Vinogradova (T)

Saint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Healthcare of the Russian Federation, 191036 Saint Petersburg, Russia.

Anastasia Lavrova (A)

Saint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Healthcare of the Russian Federation, 191036 Saint Petersburg, Russia.
Sophya Kovalevskaya North-West Mathematical Research Center, Immanuel Kant Baltic Federal University, 236041 Kaliningrad, Russia.

Petr Yablonskiy (P)

Department of Hospital Surgery, Faculty of Medicine, Saint Petersburg State University, 199034 Saint Petersburg, Russia.

Articles similaires

Mathematical modeling of vancomycin release from Poly-L-Lactic Acid-Coated implants.

Papon Thamvasupong, Kwanchanok Viravaidya-Pasuwat
1.00
Vancomycin Polyesters Anti-Bacterial Agents Models, Theoretical Drug Liberation

New emerging treatment options for metastatic melanoma: a systematic review and meta-analysis of skin cancer therapies.

Anan S Jarab, Walid A Al-Qerem, Lina M Khdour et al.
1.00
Humans Melanoma Skin Neoplasms Antineoplastic Combined Chemotherapy Protocols Randomized Controlled Trials as Topic

Menthol as an effective inhibitor of quorum sensing and biofilm formation in Candida albicans and Candida glabrata by targeting the transcriptional repressor TUP1.

Pouria Khodavandi, Maryam Miri Soogh, Fahimeh Alizadeh et al.
1.00
Biofilms Candida albicans Quorum Sensing Candida glabrata Menthol

Naturally derived 3-aminoquinuclidine salts as new promising therapeutic agents.

Doris Crnčević, Alma Ramić, Andreja Radman Kastelic et al.
1.00
Humans Microbial Sensitivity Tests Anti-Bacterial Agents Biofilms Quinuclidines

Classifications MeSH

questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Bâtonnets à Gram positif › Bâtonnets asporogènes à Gram positif › Bâtonnets asporogènes réguliers à Gram positif › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis › The Nitrofuran-Warhead-Equipped Spirocyclic...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Antituberculeux › The Nitrofuran-Warhead-Equipped Spirocyclic...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Tests de sensibilité microbienne › The Nitrofuran-Warhead-Equipped Spirocyclic...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azétines › Azétidines › The Nitrofuran-Warhead-Equipped Spirocyclic...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Furanes › Nitrofuranes › The Nitrofuran-Warhead-Equipped Spirocyclic...
questionsmedicales.fr › Composés polycycliques › Spiranes › The Nitrofuran-Warhead-Equipped Spirocyclic...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › The Nitrofuran-Warhead-Equipped Spirocyclic...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › The Nitrofuran-Warhead-Equipped Spirocyclic...