Synthesis and In Silico Analysis of New Polyheterocyclic Molecules Derived from [1,4]-Benzoxazin-3-one and Their Inhibitory Effect against Pancreatic α-Amylase and Intestinal α-Glucosidase.
Glycoside Hydrolase Inhibitors
/ pharmacology
Molecular Docking Simulation
Benzoxazines
/ chemistry
alpha-Glucosidases
/ metabolism
Pancreatic alpha-Amylases
/ antagonists & inhibitors
Cycloaddition Reaction
Molecular Structure
Computer Simulation
Hypoglycemic Agents
/ chemistry
Humans
Structure-Activity Relationship
Heterocyclic Compounds
/ chemistry
alpha-Amylases
/ antagonists & inhibitors
Intestines
/ enzymology
1,2,3-triazole
1,3-dipolar cycloaddition
[1,4]-benzoxazin-3-one
click chemistry
in silico molecular docking
isoxazoline
α-amylase
α-glucosidase
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
28 Jun 2024
28 Jun 2024
Historique:
received:
27
05
2024
revised:
22
06
2024
accepted:
24
06
2024
medline:
13
7
2024
pubmed:
13
7
2024
entrez:
13
7
2024
Statut:
epublish
Résumé
This study focuses on synthesizing a new series of isoxazolinyl-1,2,3-triazolyl-[1,4]-benzoxazin-3-one derivatives
Identifiants
pubmed: 38999038
pii: molecules29133086
doi: 10.3390/molecules29133086
pii:
doi:
Substances chimiques
Glycoside Hydrolase Inhibitors
0
Benzoxazines
0
alpha-Glucosidases
EC 3.2.1.20
Pancreatic alpha-Amylases
EC 3.2.1.1
Hypoglycemic Agents
0
Heterocyclic Compounds
0
alpha-Amylases
EC 3.2.1.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : King Saud University in Riyadh, Saudi Arabia
ID : RSP2024R119