Modelling intracellular transport in crowded environments: effects of motor association to cargos.
Journal
The European physical journal. E, Soft matter
ISSN: 1292-895X
Titre abrégé: Eur Phys J E Soft Matter
Pays: France
ID NLM: 101126530
Informations de publication
Date de publication:
13 Jul 2024
13 Jul 2024
Historique:
received:
22
10
2023
accepted:
10
06
2024
medline:
14
7
2024
pubmed:
14
7
2024
entrez:
13
7
2024
Statut:
epublish
Résumé
In intracellular transports, motor proteins transport macromolecules as cargos to desired locations by moving on biopolymers such as microtubules. Recent experiments suggest that, while moving in crowded environments, cargos that can associate motor proteins during their translocation have larger run-length and association time compared to free motors. Here, we model the dynamics of a cargo that can associate at the most m free motors present on the microtubule track as obstacles to its motion. The proposed models display competing effects of association and crowding, leading to a peak in the run-length with the free-motor density. For
Identifiants
pubmed: 39002103
doi: 10.1140/epje/s10189-024-00440-9
pii: 10.1140/epje/s10189-024-00440-9
doi:
Substances chimiques
Molecular Motor Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
47Informations de copyright
© 2024. The Author(s), under exclusive licence to EDP Sciences, SIF and Springer-Verlag GmbH Germany, part of Springer Nature.
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