Maternal vitamin A and D status in second and third trimester of pregnancy and bone mineral content in offspring at nine years of age.


Journal

Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782

Informations de publication

Date de publication:
2024
Historique:
received: 15 04 2024
accepted: 17 06 2024
medline: 15 7 2024
pubmed: 15 7 2024
entrez: 15 7 2024
Statut: epublish

Résumé

Maternal nutritional and vitamin status during pregnancy may have long-term effects on offspring health and disease. The aim of this study was to examine the associations between maternal vitamin A and D status in pregnancy and offspring bone mineral content (BMC) at nine years of age. This is a A total of 119 mother and child pairs were included in the analyses. Vitamin A insufficiency (retinol We observed a high prevalence of vitamin A insufficiency and vitamin D deficiency during pregnancy. A negative association between mid-pregnancy vitamin A status and spine BMC was observed in boys, but not girls, while no associations were found between maternal vitamin D status and child BMC. The implications of optimal vitamin A and D status in pregnancy for offspring bone health, remains a subject for further investigations.

Identifiants

pubmed: 39006361
doi: 10.3389/fendo.2024.1417656
pmc: PMC11239386
doi:

Substances chimiques

Vitamin A 11103-57-4
Vitamin D 1406-16-2

Types de publication

Journal Article Randomized Controlled Trial

Langues

eng

Sous-ensembles de citation

IM

Pagination

1417656

Informations de copyright

Copyright © 2024 Stunes, Mosti, Gustafsson, Børsting, Thorsby, Stafne and Syversen.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Auteurs

Astrid Kamilla Stunes (AK)

Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
Center for Oral Health Services and Research, Mid-Norway (TkMidt), Trondheim, Norway.

Mats Peder Mosti (MP)

Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
Department of Research and Development, Clinic of Substance Use and Addiction Medicine, St. Olavs University Hospital, Trondheim, Norway.

Miriam Katarina Gustafsson (MK)

Department of Public Health and Nursing, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.

Torunn Børsting (T)

Center for Oral Health Services and Research, Mid-Norway (TkMidt), Trondheim, Norway.
Department of Public Health and Nursing, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.

Per Medbøe Thorsby (PM)

Hormone Laboratory, Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway.
Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.

Signe Nilssen Stafne (SN)

Department of Public Health and Nursing, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
Clinic of Rehabilitation, St. Olavs University Hospital, Trondheim, Norway.

Unni Syversen (U)

Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
Department of Endocrinology, Clinic of Medicine, St. Olavs University Hospital, Trondheim, Norway.

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Classifications MeSH