The infrapatellar fat pad in inflammaging, knee joint health, and osteoarthritis.
Journal
npj aging
ISSN: 2731-6068
Titre abrégé: NPJ Aging
Pays: England
ID NLM: 9918402285106676
Informations de publication
Date de publication:
15 Jul 2024
15 Jul 2024
Historique:
received:
23
03
2024
accepted:
12
06
2024
medline:
16
7
2024
pubmed:
16
7
2024
entrez:
15
7
2024
Statut:
epublish
Résumé
Osteoarthritis (OA) is the most common form of arthritis and accounts for nearly $140 billion in annual healthcare expenditures only in the United States. Obesity, aging, and joint injury are major risk factors for OA development and progression, but the mechanisms contributing to pathology remain unclear. Emerging evidence suggests that cellular dysregulation and inflammation in joint tissues, including intra-articular adipose tissue depots, may contribute to disease severity. In particular, the infrapatellar fat pad (IFP), located in the knee joint, which provides a protective cushion for joint loading, also secretes multiple endocrine factors and inflammatory cytokines (inflammaging) that can regulate joint physiology and disease. Correlates of cartilage degeneration and OA-associated disease severity include inflammation and fibrosis of IFP in model organisms and human studies. In this article, we discuss recent progress in understanding the roles and regulation of intra-articular fat tissue in regulating joint biology and OA.
Identifiants
pubmed: 39009582
doi: 10.1038/s41514-024-00159-z
pii: 10.1038/s41514-024-00159-z
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
34Subventions
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases)
ID : DK123356
Informations de copyright
© 2024. The Author(s).
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