Sleep architecture in idiopathic hypersomnia: the influence of age, sex, and body mass index.

Humans Female Body Mass Index Adult Male Idiopathic Hypersomnia / physiopathology Middle Aged Polysomnography Retrospective Studies Age Factors Sleep / physiology Sleep, REM / physiology Sex Factors Young Adult Case-Control Studies Sleep Stages / physiology
Excessive daytime sleepiness Hypersomnolence Polysomnography Sleep architecture Sleep disorders

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
16 Jul 2024
Historique:
received: 01 03 2024
accepted: 09 07 2024
medline: 17 7 2024
pubmed: 17 7 2024
entrez: 16 7 2024
Statut: epublish

Résumé

This study aimed to progress the understanding of idiopathic hypersomnia (IH) by assessing the moderating influence of individual characteristics, such as age, sex, and body mass index (BMI) on sleep architecture. In this retrospective study, 76 IH participants (38.1 ± 11.3 years; 40 women) underwent a clinical interview, an in-laboratory polysomnography with a maximal 9-h time in bed and a multiple sleep latency test (MSLT). They were compared to 106 healthy controls (38.1 ± 14.1 years; 60 women). Multiple regressions were used to assess moderating influence of age, sex, and BMI on sleep variables. We used correlations to assess whether sleep variables were associated with Epworth Sleepiness Scale scores and mean sleep onset latency on the MSLT in IH participants. Compared to controls, IH participants had shorter sleep latency (p = 0.002), longer total sleep time (p < 0.001), more time spent in N2 sleep (p = 0.008), and showed trends for a higher sleep efficiency (p = 0.023) and more time spent in rapid eye movement (REM) sleep (p = 0.022). No significant moderating influence of age, sex, or BMI was found. More severe self-reported sleepiness in IH patients was correlated with shorter REM sleep latency and less N1 sleep in terms of proportion and duration (ps < 0.01). This study shows that, when compared to healthy controls, patients with IH had no anomalies in their sleep architecture that can explain their excessive daytime sleepiness. Moreover, there is no moderating influence of age, sex, and BMI, suggesting that the absence of major group differences is relatively robust.

Identifiants

DOI: 10.1038/s41598-024-67203-6 PMID: 39013985
pubmed: 39013985
doi: 10.1038/s41598-024-67203-6
pii: 10.1038/s41598-024-67203-6
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

16407

Subventions

Organisme : American Academy of Sleep Medicine Foundation
ID : #227-SR-20

Informations de copyright

© 2024. The Author(s).

Références

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Auteurs

Anne-Sophie Deshaies-Rugama (AS)

Center for Advanced Research in Sleep Medicine, Research Center of the Centre Intégré Universitaire de Santé et de Services Sociaux du Nord de l'Île-de-Montréal, Montreal, Canada.
Department of Psychology, Université de Montréal, Montreal, Canada.

Samantha Mombelli (S)

Center for Advanced Research in Sleep Medicine, Research Center of the Centre Intégré Universitaire de Santé et de Services Sociaux du Nord de l'Île-de-Montréal, Montreal, Canada.
Department of Psychiatry and Addictology, Université de Montréal, Montréal, Canada.

Hélène Blais (H)

Center for Advanced Research in Sleep Medicine, Research Center of the Centre Intégré Universitaire de Santé et de Services Sociaux du Nord de l'Île-de-Montréal, Montreal, Canada.

Zoran Sekerovic (Z)

Center for Advanced Research in Sleep Medicine, Research Center of the Centre Intégré Universitaire de Santé et de Services Sociaux du Nord de l'Île-de-Montréal, Montreal, Canada.

MiaClaude Massicotte (M)

Center for Advanced Research in Sleep Medicine, Research Center of the Centre Intégré Universitaire de Santé et de Services Sociaux du Nord de l'Île-de-Montréal, Montreal, Canada.
Department of Psychology, Université de Montréal, Montreal, Canada.

Cynthia Thompson (C)

Center for Advanced Research in Sleep Medicine, Research Center of the Centre Intégré Universitaire de Santé et de Services Sociaux du Nord de l'Île-de-Montréal, Montreal, Canada.

Milan Nigam (M)

Center for Advanced Research in Sleep Medicine, Research Center of the Centre Intégré Universitaire de Santé et de Services Sociaux du Nord de l'Île-de-Montréal, Montreal, Canada.
Department of Neuroscience, Université de Montréal, Montreal, Canada.

Julie Carrier (J)

Center for Advanced Research in Sleep Medicine, Research Center of the Centre Intégré Universitaire de Santé et de Services Sociaux du Nord de l'Île-de-Montréal, Montreal, Canada.
Department of Psychology, Université de Montréal, Montreal, Canada.

Alex Desautels (A)

Center for Advanced Research in Sleep Medicine, Research Center of the Centre Intégré Universitaire de Santé et de Services Sociaux du Nord de l'Île-de-Montréal, Montreal, Canada.
Department of Neuroscience, Université de Montréal, Montreal, Canada.

Jacques Montplaisir (J)

Center for Advanced Research in Sleep Medicine, Research Center of the Centre Intégré Universitaire de Santé et de Services Sociaux du Nord de l'Île-de-Montréal, Montreal, Canada.
Department of Psychiatry and Addictology, Université de Montréal, Montréal, Canada.

Nadia Gosselin (N)

Center for Advanced Research in Sleep Medicine, Research Center of the Centre Intégré Universitaire de Santé et de Services Sociaux du Nord de l'Île-de-Montréal, Montreal, Canada. nadia.gosselin@umontreal.ca.
Department of Psychology, Université de Montréal, Montreal, Canada. nadia.gosselin@umontreal.ca.
Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Cœur de Montréal, 5400 Boul. Gouin Ouest, Office J-5135, Montréal, Québec, H4J 1C5, Canada. nadia.gosselin@umontreal.ca.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Sleep architecture in idiopathic hypersomnia:...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Mesures épidémiologiques › Biométrie › Anthropométrie › Indice de masse corporelle › Sleep architecture in idiopathic hypersomnia:...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sleep architecture in idiopathic hypersomnia:...
questionsmedicales.fr › Troubles mentaux › Troubles de la veille et du sommeil › Dyssomnies › Troubles du sommeil d'origine intrinsèque › Troubles du sommeil par somnolence excessive › Hypersomnie idiopathique › Sleep architecture in idiopathic hypersomnia:...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Sleep architecture in idiopathic hypersomnia:...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Monitorage physiologique › Polysomnographie › Sleep architecture in idiopathic hypersomnia:...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études rétrospectives › Sleep architecture in idiopathic hypersomnia:...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Facteurs épidémiologiques › Facteurs âges › Sleep architecture in idiopathic hypersomnia:...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Sommeil › Sleep architecture in idiopathic hypersomnia:...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Sommeil › Phases du sommeil › Sommeil paradoxal › Sleep architecture in idiopathic hypersomnia:...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Facteurs épidémiologiques › Facteurs sexuels › Sleep architecture in idiopathic hypersomnia:...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Jeune adulte › Sleep architecture in idiopathic hypersomnia:...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études cas-témoins › Sleep architecture in idiopathic hypersomnia:...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Sommeil › Phases du sommeil › Sleep architecture in idiopathic hypersomnia:...