Discovery of Two Highly Selective Structurally Orthogonal Chemical Probes for Activin Receptor-like Kinases 1 and 2.

Journal

Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531

Informations de publication

Date de publication:
18 Jul 2024
Historique:
medline: 18 7 2024
pubmed: 18 7 2024
entrez: 18 7 2024
Statut: aheadofprint

Résumé

Activin receptor-like kinases 1-7 (ALK1-7) regulate a complex network of SMAD-independent as well as SMAD-dependent signaling pathways. One of the widely used inhibitors for functional investigations of these processes, in particular for bone morphogenetic protein (BMP) signaling, is

Identifiants

DOI: 10.1021/acs.jmedchem.4c00629 PMID: 39023313
pubmed: 39023313
doi: 10.1021/acs.jmedchem.4c00629
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Auteurs

Václav Němec (V)

Institute for Pharmaceutical Chemistry, Structural Genomics Consortium, Johann Wolfgang Goethe-University, Max-von-Laue-Strasse 9, Frankfurt am Main, 60438, Germany.
Department of Chemistry, Masaryk University, Brno 625 00, Czech Republic.
ORCID: 0000-0001-6900-1368

Marek Remeš (M)

Department of Chemistry, Masaryk University, Brno 625 00, Czech Republic.
ORCID: 0000-0003-3462-7517

Petr Beňovský (P)

Department of Chemistry, Masaryk University, Brno 625 00, Czech Republic.

Michael C Böck (MC)

Department of Chemistry, Masaryk University, Brno 625 00, Czech Republic.

Eliška Šranková (E)

Department of Chemistry, Masaryk University, Brno 625 00, Czech Republic.

Jong Fu Wong (JF)

Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, U.K.

Julien Cros (J)

Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, U.K.
ORCID: 0000-0003-3922-3036

Eleanor Williams (E)

Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, U.K.

Lap Hang Tse (LH)

Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, U.K.
ORCID: 0000-0002-5468-4626

David Smil (D)

Drug Discovery Program, Ontario Institute for Cancer Research, 661 University Avenue, Toronto, Ontario M5G 0A3, Canada.
ORCID: 0000-0002-6232-6087

Deeba Ensan (D)

Drug Discovery Program, Ontario Institute for Cancer Research, 661 University Avenue, Toronto, Ontario M5G 0A3, Canada.

Methvin B Isaac (MB)

Drug Discovery Program, Ontario Institute for Cancer Research, 661 University Avenue, Toronto, Ontario M5G 0A3, Canada.
ORCID: 0000-0001-6424-5523

Rima Al-Awar (R)

Drug Discovery Program, Ontario Institute for Cancer Research, 661 University Avenue, Toronto, Ontario M5G 0A3, Canada.
Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

Regina Gomolková (R)

Department of Biology, Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic.
Institute of Animal Physiology and Genetics of the Czech Academy of Sciences, 602 00 Brno, Czech Republic.

Vlad-Constantin Ursachi (VC)

Department of Biology, Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic.
International Clinical Research Center, St. Anne's University Hospital, 602 00 Brno, Czech Republic.

Bohumil Fafílek (B)

Department of Biology, Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic.
Institute of Animal Physiology and Genetics of the Czech Academy of Sciences, 602 00 Brno, Czech Republic.
International Clinical Research Center, St. Anne's University Hospital, 602 00 Brno, Czech Republic.

Zuzana Kahounová (Z)

Institute of Biophysics of the Czech Academy of Sciences, Královopolská 135, 612 00 Brno Czech Republic.

Ráchel Víchová (R)

Institute of Biophysics of the Czech Academy of Sciences, Královopolská 135, 612 00 Brno Czech Republic.

Ondřej Vacek (O)

International Clinical Research Center, St. Anne's University Hospital, 602 00 Brno, Czech Republic.
Institute of Biophysics of the Czech Academy of Sciences, Královopolská 135, 612 00 Brno Czech Republic.

Benedict-Tilman Berger (BT)

Institute for Pharmaceutical Chemistry, Structural Genomics Consortium, Johann Wolfgang Goethe-University, Max-von-Laue-Strasse 9, Frankfurt am Main, 60438, Germany.
ORCID: 0000-0002-3314-2617

Carrow I Wells (CI)

Structural Genomics Consortium, UNC Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.

Cesear R Corona (CR)

Promega Corporation, Madison, Wisconsin 53716, United States.

James D Vasta (JD)

Promega Corporation, Madison, Wisconsin 53716, United States.

Matthew B Robers (MB)

Promega Corporation, Madison, Wisconsin 53716, United States.

Pavel Krejci (P)

Department of Biology, Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic.
Institute of Animal Physiology and Genetics of the Czech Academy of Sciences, 602 00 Brno, Czech Republic.
International Clinical Research Center, St. Anne's University Hospital, 602 00 Brno, Czech Republic.

Karel Souček (K)

International Clinical Research Center, St. Anne's University Hospital, 602 00 Brno, Czech Republic.
Institute of Biophysics of the Czech Academy of Sciences, Královopolská 135, 612 00 Brno Czech Republic.

Alex N Bullock (AN)

Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, U.K.
ORCID: 0000-0001-6757-0436

Stefan Knapp (S)

Institute for Pharmaceutical Chemistry, Structural Genomics Consortium, Johann Wolfgang Goethe-University, Max-von-Laue-Strasse 9, Frankfurt am Main, 60438, Germany.
ORCID: 0000-0001-5995-6494

Kamil Paruch (K)

Department of Chemistry, Masaryk University, Brno 625 00, Czech Republic.
Institute of Animal Physiology and Genetics of the Czech Academy of Sciences, 602 00 Brno, Czech Republic.
ORCID: 0000-0001-9502-3173

Classifications MeSH