Paediatric schistosomiasis: last mile preparations for deploying paediatric praziquantel.

arPZQ implementation research paediatric praziquantel schistosomiasis

Journal

Trends in parasitology
ISSN: 1471-5007
Titre abrégé: Trends Parasitol
Pays: England
ID NLM: 100966034

Informations de publication

Date de publication:
19 Jul 2024
Historique:
received: 15 05 2024
revised: 12 06 2024
accepted: 19 06 2024
medline: 21 7 2024
pubmed: 21 7 2024
entrez: 20 7 2024
Statut: aheadofprint

Résumé

Schistosomiasis is the second most important parasitic disease of public health importance in Africa, affecting over 50 million children aged <5 years old. Schistosomiasis control has focused on treating school-aged children (>6 years) and adults through mass drug administration (MDA). Following the recent development of a paediatric praziquantel (PZQ) formulation for children aged <5 years, there are now concerted efforts to determine optimal and effective ways to integrate treatment of these children into national schistosomiasis control programmes. In this opinion article we outline the pathway for successful drug access, delivery, and mainstreaming of the new formulation in endemic country health systems. Effective and sustained paediatric schistosomiasis treatment is an important target of the 2030 World Health Organization (WHO) neglected tropical diseases (NTDs) roadmap.

Identifiants

pubmed: 39033047
pii: S1471-4922(24)00169-7
doi: 10.1016/j.pt.2024.06.011
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2024. Published by Elsevier Ltd.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

Auteurs

Francisca Mutapi (F)

Institute of Immunology and Infection Research, University of Edinburgh, Ashworth Laboratories, King's Buildings, Charlotte Auerbach Road, Edinburgh EH9 3FL, UK; Tackling Infections to Benefit Africa (TIBA) Partnership, TIBA Global Health Research Unit, University of Edinburgh, Ashworth Laboratories, King's Buildings, Charlotte Auerbach Road, Edinburgh, EH9 3FL, UK. Electronic address: f.mutapi@ed.ac.uk.

Amadou Garba (A)

Department of the Control of Neglected Tropical Diseases, World Health Organization, Geneva, 1211, Switzerland.

Mark Woolhouse (M)

Tackling Infections to Benefit Africa (TIBA) Partnership, TIBA Global Health Research Unit, University of Edinburgh, Ashworth Laboratories, King's Buildings, Charlotte Auerbach Road, Edinburgh, EH9 3FL, UK; Usher Institute of Population Health Sciences and Informatics, Ashworth Laboratories, University of Edinburgh, Edinburgh, UK.

Paul Kazyoba (P)

National Institute for Medical Research, 2448 Barack Obama Dr, Dar es Salaam, Tanzania; TIBA Partnership, NIMR, Tanzania, 2448 Barack Obama Dr, Dar es Salaam, Tanzania.

Classifications MeSH