Systematic review of the mechanism and assessment of liver fibrosis in biliary atresia.
Biliary atresia (BA)
Grading
Liver fibrosis
Systematic review
Journal
Pediatric surgery international
ISSN: 1437-9813
Titre abrégé: Pediatr Surg Int
Pays: Germany
ID NLM: 8609169
Informations de publication
Date de publication:
20 Jul 2024
20 Jul 2024
Historique:
accepted:
06
07
2024
medline:
21
7
2024
pubmed:
21
7
2024
entrez:
20
7
2024
Statut:
epublish
Résumé
This study systematically reviewed our team's research on the mechanism and assessment of liver fibrosis in BA, summarized our experience, and discussed the future development direction. In this study, Pubmed and Wanfang databases were searched to collect the literature published by our team on the mechanisms of liver fibrosis in BA and the assessment of liver fibrosis in BA, and the above research results were systematically reviewed. A total of 58 articles were retrieved. Among the included articles, 25 articles related to the mechanism of liver fibrosis in BA, and five articles evaluated liver fibrosis in BA. This article introduces the key pathways and molecules of liver fibrosis in BA and proposes a new grading system for liver fibrosis in BA. The new BA liver fibrosis grading method is expected to assess children's conditions, guide treatment, and improve prognosis more accurately. In addition, we believe that the TGF-β1 signaling pathway is the most important in the study of liver fibrosis in BA, and at the same time, the study of EMT occurrence in BA should also be deepened to resolve the controversy on this issue.
Identifiants
pubmed: 39033225
doi: 10.1007/s00383-024-05778-x
pii: 10.1007/s00383-024-05778-x
doi:
Substances chimiques
Transforming Growth Factor beta1
0
Types de publication
Journal Article
Systematic Review
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
205Subventions
Organisme : Tianjin Science and Technology Program
ID : No.21ZXGWSY00070
Organisme : Tianjin Science and Technology Program
ID : No.21ZXGWSY00070
Organisme : Tianjin Science and Technology Program
ID : No.21ZXGWSY00070
Organisme : Tianjin Applied Basic Research Project
ID : No.22JCZDJC00290
Organisme : Tianjin Applied Basic Research Project
ID : No.22JCZDJC00290
Organisme : Tianjin Applied Basic Research Project
ID : No.22JCZDJC00290
Organisme : Tianjin Applied Basic Research Project
ID : No.22JCZDJC00290
Informations de copyright
© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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