Chemical Synthesis of Interleukin-6 for Mirror-Image Screening.
Journal
Bioconjugate chemistry
ISSN: 1520-4812
Titre abrégé: Bioconjug Chem
Pays: United States
ID NLM: 9010319
Informations de publication
Date de publication:
23 Jul 2024
23 Jul 2024
Historique:
medline:
23
7
2024
pubmed:
23
7
2024
entrez:
23
7
2024
Statut:
aheadofprint
Résumé
Interleukin-6 (IL-6), a multifunctional cytokine, is an attractive therapeutic target for immunological and inflammatory diseases. We investigated the chemical synthesis of IL-6 and its enantiomer (d-IL-6) using a sequential N-to-C native chemical ligation strategy from six peptide segments. Solubilizing Trt-K
Identifiants
pubmed: 39042943
doi: 10.1021/acs.bioconjchem.4c00204
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM