Intergenerational effects of racism on amygdala and hippocampus resting state functional connectivity.
Amygdala
Functional connectivity
Hippocampus
Racism
Trauma
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
24 Jul 2024
24 Jul 2024
Historique:
received:
25
03
2024
accepted:
04
07
2024
medline:
24
7
2024
pubmed:
24
7
2024
entrez:
23
7
2024
Statut:
epublish
Résumé
Racism is an insidious problem with far-reaching effects on the lives of Black, Indigenous, and People of Color (BIPOC). The pervasive negative impact of racism on mental health is well documented. However, less is known about the potential downstream impacts of maternal experiences of racism on offspring neurodevelopment. This study sought to examine evidence for a biological pathway of intergenerational transmission of racism-related trauma. This study examined the effects of self-reported maternal experiences of racism on resting state functional connectivity (rsFC) in n = 25 neonates (13 female, 12 male) birthed by BIPOC mothers. Amygdala and hippocampus are brain regions involved in fear, memory, and anxiety, and are central nodes in brain networks associated with trauma-related change. We used average scores on the Experiences of Racism Scale as a continuous, voxel-wise regressor in seed-based, whole-brain connectivity analysis of anatomically defined amygdala and hippocampus seed regions of interest. All analyses controlled for infant sex and gestational age at the 2-week scanning session. More maternal racism-related experiences were associated with (1) stronger right amygdala rsFC with visual cortex and thalamus; and (2) stronger hippocampus rsFC with visual cortex and a temporo-parietal network, in neonates. The results of this research have implications for understanding how maternal experiences of racism may alter neurodevelopment, and for related social policy.
Identifiants
pubmed: 39043776
doi: 10.1038/s41598-024-66830-3
pii: 10.1038/s41598-024-66830-3
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
17034Subventions
Organisme : Eunice Kennedy Shriver National Institute of Child Health and Human Development
ID : R01 HD091148-05
Organisme : Eunice Kennedy Shriver National Institute of Child Health and Human Development
ID : R01 HD091148-05
Organisme : Eunice Kennedy Shriver National Institute of Child Health and Human Development
ID : R01 HD091148-05
Organisme : Eunice Kennedy Shriver National Institute of Child Health and Human Development
ID : R01 HD091148-05
Organisme : Eunice Kennedy Shriver National Institute of Child Health and Human Development
ID : R01 HD091148-05
Organisme : Eunice Kennedy Shriver National Institute of Child Health and Human Development
ID : R01 HD091148-05
Organisme : Eunice Kennedy Shriver National Institute of Child Health and Human Development
ID : R01 HD091148-05
Organisme : Eunice Kennedy Shriver National Institute of Child Health and Human Development
ID : R01 HD091148-05
Organisme : Eunice Kennedy Shriver National Institute of Child Health and Human Development
ID : R01 HD091148-05
Organisme : NIMH NIH HHS
ID : T32MH018931-31
Pays : United States
Informations de copyright
© 2024. The Author(s).
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