In vitro selection and analysis of SARS-CoV-2 nirmatrelvir resistance mutations contributing to clinical virus resistance surveillance.

SARS-CoV-2 / genetics Drug Resistance, Viral / genetics Humans Antiviral Agents / pharmacology Mutation COVID-19 Drug Treatment COVID-19 / virology Coronavirus 3C Proteases / genetics Lactams Leucine Nitriles Proline

Journal

Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440

Informations de publication

Date de publication:
26 Jul 2024
Historique:
medline: 26 7 2024
pubmed: 26 7 2024
entrez: 24 7 2024
Statut: ppublish

Résumé

To facilitate the detection and management of potential clinical antiviral resistance, in vitro selection of drug-resistant severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) against the virus M

Identifiants

DOI: 10.1126/sciadv.adl4013 PMID: 39047088
pubmed: 39047088
doi: 10.1126/sciadv.adl4013
doi:

Substances chimiques

Antiviral Agents 0
nirmatrelvir 7R9A5P7H32
Coronavirus 3C Proteases EC 3.4.22.28
Lactams 0
Leucine GMW67QNF9C
Nitriles 0
Proline 9DLQ4CIU6V

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

eadl4013

Auteurs

Yuao Zhu (Y)

Pfizer Worldwide Research, Development & Medical, Pearl River, NY 10965, USA.
ORCID: 0000-0001-9831-6836

Irina Yurgelonis (I)

Pfizer Worldwide Research, Development & Medical, Pearl River, NY 10965, USA.
ORCID: 0009-0003-2081-7907

Stephen Noell (S)

Pfizer Worldwide Research, Development & Medical, Groton, CT 06340, USA.
ORCID: 0000-0003-3054-2575

Qingyi Yang (Q)

Pfizer Worldwide Research, Development & Medical, Cambridge MA 02139, USA.

Shunjie Guan (S)

Pfizer Worldwide Research, Development & Medical, Cambridge MA 02139, USA.

Zhenghui Li (Z)

Pfizer Worldwide Research, Development & Medical, Pearl River, NY 10965, USA.

Li Hao (L)

Pfizer Worldwide Research, Development & Medical, Pearl River, NY 10965, USA.
ORCID: 0000-0002-8865-7351

Hussin Rothan (H)

Pfizer Worldwide Research, Development & Medical, Pearl River, NY 10965, USA.

Devendra K Rai (DK)

Pfizer Worldwide Research, Development & Medical, Pearl River, NY 10965, USA.

Patricia McMonagle (P)

Pfizer Worldwide Research, Development & Medical, Pearl River, NY 10965, USA.
ORCID: 0009-0007-8369-021X

Mary Lynn Baniecki (ML)

Pfizer Worldwide Research, Development & Medical, Cambridge MA 02139, USA.
ORCID: 0000-0003-3862-7231

Samantha E Greasley (SE)

Pfizer Worldwide Research, Development & Medical, La Jolla, CA 92121, USA.
ORCID: 0000-0002-7978-6477

Olga Plotnikova (O)

Pfizer Worldwide Research, Development & Medical, Groton, CT 06340, USA.

Jonathan Lee (J)

Pfizer Worldwide Research, Development & Medical, Pearl River, NY 10965, USA.

Jennifer A Nicki (JA)

Pfizer Worldwide Research, Development & Medical, Groton, CT 06340, USA.
ORCID: 0000-0002-5440-2991

RoseAnn Ferre (R)

Pfizer Worldwide Research, Development & Medical, La Jolla, CA 92121, USA.
ORCID: 0000-0001-7462-1879

Laura J Byrnes (LJ)

Pfizer Worldwide Research, Development & Medical, Groton, CT 06340, USA.
ORCID: 0000-0003-0614-4139

Wei Liu (W)

Pfizer Worldwide Research, Development & Medical, La Jolla, CA 92121, USA.

Timothy K Craig (TK)

Pfizer Worldwide Research, Development & Medical, Groton, CT 06340, USA.
ORCID: 0000-0002-4625-444X

Claire M Steppan (CM)

Pfizer Worldwide Research, Development & Medical, Groton, CT 06340, USA.
ORCID: 0000-0002-2609-7707

Paul Liberator (P)

Pfizer Worldwide Research, Development & Medical, Pearl River, NY 10965, USA.
ORCID: 0000-0001-8298-5779

Holly D Soares (HD)

Pfizer Worldwide Research, Development & Medical, Groton, CT 06340, USA.
ORCID: 0000-0002-6140-9841

Charlotte M N Allerton (CMN)

Pfizer Worldwide Research, Development & Medical, Cambridge MA 02139, USA.
ORCID: 0000-0001-8665-159X

Annaliesa S Anderson (AS)

Pfizer Worldwide Research, Development & Medical, Pearl River, NY 10965, USA.

Rhonda D Cardin (RD)

Pfizer Worldwide Research, Development & Medical, Pearl River, NY 10965, USA.
ORCID: 0000-0003-2390-8591

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Classifications MeSH

questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Virus du SRAS › SARS-CoV-2 › In vitro selection and analysis of SARS-CoV-2...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Résistance microbienne aux médicaments › Résistance virale aux médicaments › In vitro selection and analysis of SARS-CoV-2...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › In vitro selection and analysis of SARS-CoV-2...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiviraux › In vitro selection and analysis of SARS-CoV-2...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › In vitro selection and analysis of SARS-CoV-2...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Traitements médicamenteux de la COVID-19 › In vitro selection and analysis of SARS-CoV-2...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › In vitro selection and analysis of SARS-CoV-2...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines virales › Protéines virales non structurales › Protéases virales › Protéases virales 3C › Protéases 3C des coronavirus › In vitro selection and analysis of SARS-CoV-2...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Lactames › In vitro selection and analysis of SARS-CoV-2...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés essentiels › Leucine › In vitro selection and analysis of SARS-CoV-2...
questionsmedicales.fr › Composés chimiques organiques › Nitriles › In vitro selection and analysis of SARS-CoV-2...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés cycliques › Imino-acides › Proline › In vitro selection and analysis of SARS-CoV-2...