Cement loaded with high-dose gentamicin and clindamycin does not reduce the risk of subsequent infection after aseptic total hip or knee revision arthroplasty: a preliminary study.
Humans
Gentamicins
/ administration & dosage
Clindamycin
/ administration & dosage
Arthroplasty, Replacement, Hip
/ adverse effects
Retrospective Studies
Male
Female
Bone Cements
Reoperation
Arthroplasty, Replacement, Knee
/ adverse effects
Aged
Anti-Bacterial Agents
/ administration & dosage
Middle Aged
Surgical Wound Infection
/ prevention & control
Prosthesis-Related Infections
/ prevention & control
Risk Factors
Aseptic revision
Dual antibiotic loaded bone cement
Periprosthetic joint infection
Surgical site infection
Journal
Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology
ISSN: 1590-9999
Titre abrégé: J Orthop Traumatol
Pays: Italy
ID NLM: 101090931
Informations de publication
Date de publication:
24 Jul 2024
24 Jul 2024
Historique:
received:
23
01
2024
accepted:
15
06
2024
medline:
26
7
2024
pubmed:
26
7
2024
entrez:
24
7
2024
Statut:
epublish
Résumé
The aim of this study was to quantify the prophylactic effect of high-dose gentamicin and clindamycin antibiotic-loaded bone cement (ALBC) during revision total hip (rTHA) or knee (rTKA) arthroplasty for aseptic reasons. The hypothesis was that the raw surgical site infection (SSI) rate is lower when this particular cement is used in comparison with cement loaded with standard-dose gentamicin during rTHA or rTKA for aseptic reasons. This retrospective study included 290 consecutive patients undergoing aseptic rTHA or rTKA. Two consecutive cohorts were defined: the first (control group) involved 145 patients where ALBC with gentamicin only was used; the second (study group) involved 145 patients where ALBC with high-dose gentamicin and clindamycin was used. The primary endpoint was the raw SSI rate after 24 months. The raw SSI rate was 8/145 (6%) in the control group and 13/145 (9%) in the study group (odds ratio 0.62, p = 0.26). There was a significant impact of the presence of any risk factor on the SSI rate (15/100 versus 6/169, odds ratio = 4.25, p = 0.002), but no significant impact of any individual risk factor. No complication or side effect related to ALBC was observed in either group. These results do not support the routine use of gentamicin and clindamycin ALBC for fixation of revision implants after rTHA and rTKA for aseptic reasons.
Identifiants
pubmed: 39048851
doi: 10.1186/s10195-024-00775-1
pii: 10.1186/s10195-024-00775-1
doi:
Substances chimiques
Gentamicins
0
Clindamycin
3U02EL437C
Bone Cements
0
Anti-Bacterial Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
37Informations de copyright
© 2024. The Author(s).
Références
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