RNA polymerase I mutant affects ribosomal RNA processing and ribosomal DNA stability.

DNA, Ribosomal / genetics Saccharomyces cerevisiae / genetics RNA Polymerase I / metabolism RNA, Ribosomal / genetics Saccharomyces cerevisiae Proteins / metabolism Mutation Genomic Instability RNA Processing, Post-Transcriptional Pol1 Transcription Initiation Complex Proteins
Genome stability S.cerevisiae Transcription ribosomal RNA

Journal

RNA biology
ISSN: 1555-8584
Titre abrégé: RNA Biol
Pays: United States
ID NLM: 101235328

Informations de publication

Date de publication:
Jan 2024
Historique:
medline: 26 7 2024
pubmed: 26 7 2024
entrez: 25 7 2024
Statut: ppublish

Résumé

Transcription is a major contributor to genomic instability. The ribosomal RNA (rDNA) gene locus consists of a head-to-tail repeat of the most actively transcribed genes in the genome. RNA polymerase I (RNAPI) is responsible for massive rRNA production, and nascent rRNA is co-transcriptionally assembled with early assembly factors in the yeast nucleolus. In

Identifiants

DOI: 10.1080/15476286.2024.2381910 PMID: 39049162
pubmed: 39049162
doi: 10.1080/15476286.2024.2381910
doi:

Substances chimiques

DNA, Ribosomal 0
RNA Polymerase I EC 2.7.7.6
RNA, Ribosomal 0
Saccharomyces cerevisiae Proteins 0
RRN3 protein, S cerevisiae 0
Pol1 Transcription Initiation Complex Proteins 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1-16

Auteurs

Christophe Normand (C)

Molecular, Cellular and Developmental Biology Unit (MCD), Centre de Biologie Integrative (CBI), University of Toulouse, CNRS, UPS, Toulouse, France.

Christophe Dez (C)

Molecular, Cellular and Developmental Biology Unit (MCD), Centre de Biologie Integrative (CBI), University of Toulouse, CNRS, UPS, Toulouse, France.

Lise Dauban (L)

Molecular, Cellular and Developmental Biology Unit (MCD), Centre de Biologie Integrative (CBI), University of Toulouse, CNRS, UPS, Toulouse, France.

Sophie Queille (S)

Molecular, Cellular and Developmental Biology Unit (MCD), Centre de Biologie Integrative (CBI), University of Toulouse, CNRS, UPS, Toulouse, France.

Sarah Danché (S)

Molecular, Cellular and Developmental Biology Unit (MCD), Centre de Biologie Integrative (CBI), University of Toulouse, CNRS, UPS, Toulouse, France.

Sarra Abderrahmane (S)

Molecular, Cellular and Developmental Biology Unit (MCD), Centre de Biologie Integrative (CBI), University of Toulouse, CNRS, UPS, Toulouse, France.

Frederic Beckouet (F)

Molecular, Cellular and Developmental Biology Unit (MCD), Centre de Biologie Integrative (CBI), University of Toulouse, CNRS, UPS, Toulouse, France.

Olivier Gadal (O)

Molecular, Cellular and Developmental Biology Unit (MCD), Centre de Biologie Integrative (CBI), University of Toulouse, CNRS, UPS, Toulouse, France.
ORCID: 0000-0001-9421-0831

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Classifications MeSH

questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › ADN ribosomique › RNA polymerase I mutant affects ribosomal RNA...
questionsmedicales.fr › Eucaryotes › Champignons › Levures › Saccharomyces › Saccharomyces cerevisiae › RNA polymerase I mutant affects ribosomal RNA...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Phosphotransferases › Nucleotidyltransferases › RNA nucleotidyltransferases › DNA-directed RNA polymerases › RNA polymerase I › RNA polymerase I mutant affects ribosomal RNA...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN ribosomique › RNA polymerase I mutant affects ribosomal RNA...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines fongiques › Protéines de Saccharomyces cerevisiae › RNA polymerase I mutant affects ribosomal RNA...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › RNA polymerase I mutant affects ribosomal RNA...
questionsmedicales.fr › Phénomènes génétiques › Instabilité du génome › RNA polymerase I mutant affects ribosomal RNA...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Maturation post-transcriptionnelle des ARN › RNA polymerase I mutant affects ribosomal RNA...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs généraux de transcription › Complexes protéiques d'initiation à la transcription pol1 › RNA polymerase I mutant affects ribosomal RNA...