Preferred diuretic therapy for primary hypertension: Chlorthalidone or hydrochlorothiazide?
Journal
JAAPA : official journal of the American Academy of Physician Assistants
ISSN: 1547-1896
Titre abrégé: JAAPA
Pays: United States
ID NLM: 9513102
Informations de publication
Date de publication:
01 Aug 2024
01 Aug 2024
Historique:
medline:
26
7
2024
pubmed:
26
7
2024
entrez:
25
7
2024
Statut:
ppublish
Résumé
Because of its greater reduction of major adverse cardiovascular events (MACE), chlorthalidone is recommended over hydrochlorothiazide as the preferred diuretic for patients with primary hypertension. However, hydrochlorothiazide is more commonly prescribed than chlorthalidone for this condition. This article reviews recent studies investigating the effectiveness of chlorthalidone and hydrochlorothiazide in reducing MACE, to help clinicians make an evidence-based informed decision on which diuretic to prescribe.
Identifiants
pubmed: 39051700
doi: 10.1097/01.JAA.0000000000000057
pii: 01720610-202408000-00014
doi:
Substances chimiques
Chlorthalidone
Q0MQD1073Q
Hydrochlorothiazide
0J48LPH2TH
Diuretics
0
Antihypertensive Agents
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1-2Informations de copyright
Copyright © 2024 American Academy of Physician Associates.
Références
Centers for Disease Control and Prevention. Facts about hypertension. www.cdc.gov/bloodpressure/facts.htm. Accessed April 22, 2024.
Whelton PK, Carey RM, Aronow WS, et al. 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: a report of the American College of Cardiology/American Heart Association task force on clinical practice guidelines. Hypertension. 2017;71(6):e13–e115.
Thomopoulos C, Parati G, Zanchetti A. Effects of blood pressure lowering on outcome incidence in hypertension: 4. Effects of various classes of antihypertensive drugs—overview and meta-analyses. J Hypertens. 2015;33(2):195–211.
Chlorthalidone: drug usage statistics, United States, 2013-2021. https://clincalc.com/DrugStats/Drugs/Chlorthalidone. Accessed April 22, 2024.
Hydrochlorothiazide: drug usage statistics, United States, 2013-2021. https://clincalc.com/DrugStats/Drugs/Hydrochlorothiazide. Accessed April 22, 2024.
Roush GC, Messerli FH. Chlorthalidone versus hydrochlorothiazide: major cardiovascular events, blood pressure, left ventricular mass, and adverse effects. J Hypertens. 2021;39(6):1254–1260.
Ernst ME, Fravel MA. Thiazide and the thiazide-like diuretics: review of hydrochlorothiazide, chlorthalidone, and indapamide. Am J Hypertens. 2022;35(7):573–586.
Dhalla IA, Gomes T, Yao Z, et al. Chlorthalidone versus hydrochlorothiazide for the treatment of hypertension in older adults: a population-based cohort study. Ann Intern Med. 2013;158(6):447–455.
Edwards C, Hundemer GL, Petrcich W, et al. Comparison of clinical outcomes and safety associated with chlorthalidone vs hydrochlorothiazide in older adults with varying levels of kidney function. JAMA Netw Open. 2021;4(9):e2123365.
Hripcsak G, Suchard MA, Shea S, et al. Comparison of cardiovascular and safety outcomes of chlorthalidone vs hydrochlorothiazide to treat hypertension. JAMA Intern Med. 2020;180(4):542–551.
Ishani A, Cushman WC, Leatherman SM, et al. Chlorthalidone vs. hydrochlorothiazide for hypertension-cardiovascular events. N Engl J Med. 2022;387(26):2401–2410.
Hydrochlorothiazide prices coupons, and patient assistance programs. www.drugs.com/price-guide/hydrochlorothiazide. Accessed April 22, 2024.
Chlorthalidone prices coupons, and patient assistance programs. www.drugs.com/price-guide/chlorthalidone. Accessed April 22, 2024.