Study of adverse drug reactions during the treatment of drug resistant tuberculosis.
Humans
Female
Antitubercular Agents
/ adverse effects
Male
Tuberculosis, Multidrug-Resistant
/ drug therapy
Retrospective Studies
Adult
Middle Aged
Pharmacovigilance
Young Adult
India
/ epidemiology
Adolescent
Drug-Related Side Effects and Adverse Reactions
/ epidemiology
Aged
Isoniazid
/ adverse effects
Rifampin
/ adverse effects
Risk Factors
Adverse drug event
Adverse drug reactions
Drug related side effects and adverse reaction
Drug toxicity
Drug-resistant tuberculosis
Infection
Kochs disease
Multidrug resistant tuberculosis
Mycobacterium tuberculosis
Pharmacovigilance
Prevention and control
Journal
The Indian journal of tuberculosis
ISSN: 0019-5707
Titre abrégé: Indian J Tuberc
Pays: India
ID NLM: 0373027
Informations de publication
Date de publication:
2024
2024
Historique:
received:
12
01
2024
revised:
28
02
2024
accepted:
05
03
2024
medline:
28
7
2024
pubmed:
28
7
2024
entrez:
27
7
2024
Statut:
ppublish
Résumé
Pharmacovigilance entails monitoring of patients for timely detection of ADR and reporting them so that more information about drug safety can be obtained. This may help in the future for dose modification or alteration of regimen. In NTEP, ADSm (Active Drug Safety monitoring) is part of pharmacovigilance. In this study we shall be studying ADRs to Anti TB drugs in DRTB. This study is observational, retrospective and record based, of patients admitted from 2021 to 2023 in the DOTS ward of Respiratory Medicine Department of a tertiary care hospital in Goa. Data such as age, sex, regimen, date of AKT initiation and adverse effects documented has been noted and compiled. ADRs have been tabulated in the form of tables. Statistical analysis is done to find out the commonest ADR, time when they are likely to occur, which age and gender are most likely affected and if there are any other associated risk factors for ADRs. This study will enable in future to better monitor patients with regard to particular adverse drug reaction, patient safety and if needed to alter the regimen as early as possible.
Sections du résumé
BACKGROUND
BACKGROUND
Pharmacovigilance entails monitoring of patients for timely detection of ADR and reporting them so that more information about drug safety can be obtained. This may help in the future for dose modification or alteration of regimen. In NTEP, ADSm (Active Drug Safety monitoring) is part of pharmacovigilance. In this study we shall be studying ADRs to Anti TB drugs in DRTB.
METHODOLOGY
METHODS
This study is observational, retrospective and record based, of patients admitted from 2021 to 2023 in the DOTS ward of Respiratory Medicine Department of a tertiary care hospital in Goa. Data such as age, sex, regimen, date of AKT initiation and adverse effects documented has been noted and compiled.
RESULTS
RESULTS
ADRs have been tabulated in the form of tables. Statistical analysis is done to find out the commonest ADR, time when they are likely to occur, which age and gender are most likely affected and if there are any other associated risk factors for ADRs.
CONCLUSION
CONCLUSIONS
This study will enable in future to better monitor patients with regard to particular adverse drug reaction, patient safety and if needed to alter the regimen as early as possible.
Identifiants
pubmed: 39067945
pii: S0019-5707(24)00033-7
doi: 10.1016/j.ijtb.2024.03.002
pii:
doi:
Substances chimiques
Antitubercular Agents
0
Isoniazid
V83O1VOZ8L
Rifampin
VJT6J7R4TR
Types de publication
Journal Article
Observational Study
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
S136-S140Informations de copyright
Copyright © 2024 Tuberculosis Association of India. Published by Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.