Widespread exposure to SARS-CoV-2 in wildlife communities.
Animals
COVID-19
/ transmission
SARS-CoV-2
/ genetics
Animals, Wild
/ virology
Humans
Seroepidemiologic Studies
Phylogeny
Chiroptera
/ virology
Virginia
/ epidemiology
Raccoons
/ virology
District of Columbia
/ epidemiology
Deer
/ virology
Genome, Viral
Urbanization
Antibodies, Viral
/ blood
RNA, Viral
/ genetics
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
29 Jul 2024
29 Jul 2024
Historique:
received:
22
11
2023
accepted:
20
06
2024
medline:
30
7
2024
pubmed:
30
7
2024
entrez:
29
7
2024
Statut:
epublish
Résumé
Pervasive SARS-CoV-2 infections in humans have led to multiple transmission events to animals. While SARS-CoV-2 has a potential broad wildlife host range, most documented infections have been in captive animals and a single wildlife species, the white-tailed deer. The full extent of SARS-CoV-2 exposure among wildlife communities and the factors that influence wildlife transmission risk remain unknown. We sampled 23 species of wildlife for SARS-CoV-2 and examined the effects of urbanization and human use on seropositivity. Here, we document positive detections of SARS-CoV-2 RNA in six species, including the deer mouse, Virginia opossum, raccoon, groundhog, Eastern cottontail, and Eastern red bat between May 2022-September 2023 across Virginia and Washington, D.C., USA. In addition, we found that sites with high human activity had three times higher seroprevalence than low human-use areas. We obtained SARS-CoV-2 genomic sequences from nine individuals of six species which were assigned to seven Pango lineages of the Omicron variant. The close match to variants circulating in humans at the time suggests at least seven recent human-to-animal transmission events. Our data support that exposure to SARS-CoV-2 has been widespread in wildlife communities and suggests that areas with high human activity may serve as points of contact for cross-species transmission.
Identifiants
pubmed: 39075057
doi: 10.1038/s41467-024-49891-w
pii: 10.1038/s41467-024-49891-w
doi:
Substances chimiques
Antibodies, Viral
0
RNA, Viral
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
6210Subventions
Organisme : United States Department of Agriculture | Agricultural Research Service (USDA Agricultural Research Service)
ID : AP23OA000000C004
Organisme : United States Department of Agriculture | Agricultural Research Service (USDA Agricultural Research Service)
ID : AP23OA000000C004
Organisme : United States Department of Agriculture | Agricultural Research Service (USDA Agricultural Research Service)
ID : AP23OA000000C004
Organisme : United States Department of Agriculture | Agricultural Research Service (USDA Agricultural Research Service)
ID : AP23OA000000C004
Organisme : National Science Foundation (NSF)
ID : DEB-1911853
Informations de copyright
© 2024. The Author(s).
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