Mitochondria can substitute for parvalbumin to lower cytosolic calcium levels in the murine fast skeletal muscle.
calcium
mitochondria
mouse skeletal muscle fibers
parvalbumin
reaction–diffusion model
Journal
Acta physiologica (Oxford, England)
ISSN: 1748-1716
Titre abrégé: Acta Physiol (Oxf)
Pays: England
ID NLM: 101262545
Informations de publication
Date de publication:
30 Jul 2024
30 Jul 2024
Historique:
revised:
09
07
2024
received:
23
10
2023
accepted:
15
07
2024
medline:
30
7
2024
pubmed:
30
7
2024
entrez:
30
7
2024
Statut:
aheadofprint
Résumé
Parvalbumin (PV) is a primary calcium buffer in mouse fast skeletal muscle fibers. Previous work showed that PV ablation has a limited impact on cytosolic Ca We determined the free Ca [Ca The model-based analysis of experimentally determined calcium distribution during tetanic stimulation showed that mitochondria can act as a buffer to compensate for the lack of PV. This result contributes to a better understanding of mitochondria's role in modulating [Ca
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e14208Subventions
Organisme : European Union via the Horizon 2020 Research and Innovation Programme under the Marie Sklodowska-Curie
ID : 886232
Organisme : Italian Telethon Association
ID : GGP16026
Organisme : Italian Ministry of Health
ID : GR-2016-02362779
Organisme : Italian Ministry of University and Scientific Research
ID : PRIN 20207P85MH
Organisme : Italian Telethon ONLUS
ID : GGP19231
Organisme : National Institutes of Health USA
ID : AR059646
Informations de copyright
© 2024 The Author(s). Acta Physiologica published by John Wiley & Sons Ltd on behalf of Scandinavian Physiological Society.
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