Granulomatosis with Polyangiitis: A Rare but Clinically Important Disease for the Otolaryngologist.
Journal
Nigerian journal of clinical practice
ISSN: 1119-3077
Titre abrégé: Niger J Clin Pract
Pays: India
ID NLM: 101150032
Informations de publication
Date de publication:
01 Jul 2024
01 Jul 2024
Historique:
received:
12
11
2023
accepted:
07
04
2024
medline:
31
7
2024
pubmed:
31
7
2024
entrez:
31
7
2024
Statut:
ppublish
Résumé
Granulomatosis with polyangiitis (GPA) is rare but debilitating autoimmune disease and commonly presents with sinonasal as well as other head and neck symptoms. To summarize the ear, nose, and throat-specific symptomatology and management of GPA. We performed a literature review by using the PubMed search engine to provide a summary of recent and important literature that is pertinent to an otolaryngologist's clinical practice. We provide a guide on the pathophysiology, epidemiology, clinical features, investigation, and management (operative and nonoperative) of this important disease. This review illustrates the important role that an otolaryngologist can play in the work up and symptom management of patients with GPA. Knowledge of the common presenting symptoms as well as more rare presentations of GPA is extremely important for otolaryngologists as prompt diagnosis and management is extremely important to avoid significant morbidity and mortality.
Identifiants
pubmed: 39082906
doi: 10.4103/njcp.njcp_790_23
pii: 01253091-202427070-00002
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
819-826Informations de copyright
Copyright © 2024 Copyright: © 2024 Nigerian Journal of Clinical Practice.
Références
Kitching AR, Anders H-J, Basu N, Brouwer E, Gordon J, Jayne DR, et al. ANCA-associated vasculitis. Nat Rev Dis Primers 2020;6:71.
Hunter RW, Welsh N, Farrah TE, Gallacher PJ, Dhaun N. ANCA associated vasculitis. BMJ 2020;369:m1070.
Jennette JC. Overview of the 2012 revised International Chapel Hill Consensus Conference nomenclature of vasculitides. Clin Exp Nephrol 2013;17:603–6.
Falk RJ, Terrell RS, Charles LA, Jennette JC. Anti-neutrophil cytoplasmic autoantibodies induce neutrophils to degranulate and produce oxygen radicals in vitro. Proc Natl Acad Sci U S A 1990;87:4115–9.
Cartin-Ceba R, Peikert T, Specks U. Pathogenesis of ANCA-associated vasculitis. Curr Rheumatol Rep 2012;14:481–93.
Lutalo PM, D’Cruz DP. Diagnosis and classification of granulomatosis with polyangiitis (aka Wegener’s granulomatosis). J Autoimmun 2014;48–49:94–8.
Garlapati P, Qurie A. Granulomatosis with Polyangiitis. StatPearls Treasure Island (FL): StatPearls Publishing Copyright © 2022, StatPearls Publishing LLC; 2022.
Lane SE, Watts RA, Bentham G, Innes NJ, Scott DG. Are environmental factors important in primary systemic vasculitis? A case-control study. Arthritis Rheum 2003;48:814–23.
Stegeman CA, Tervaert JW, Sluiter WJ, Manson WL, de Jong PE, Kallenberg CG. Association of chronic nasal carriage of Staphylococcus aureus and higher relapse rates in Wegener granulomatosis. Ann Intern Med 1994;120:12–7.
McDermott G, Fu X, Stone JH, Wallwork R, Zhang Y, Choi HK, et al. Association of cigarette smoking with antineutrophil cytoplasmic antibody-associated vasculitis. JAMA Intern Med 2020;180:870–6.
Chen M, Gao Y, Guo XH, Zhao MH. Propylthiouracil-induced antineutrophil cytoplasmic antibody-associated vasculitis. Nat Rev Nephrol 2012;8:476–83.
Pendergraft WF 3rd, Niles JL. Trojan horses: Drug culprits associated with antineutrophil cytoplasmic autoantibody (ANCA) vasculitis. Curr Opin Rheumatol 2014;26:42–9.
Guchelaar NAD, Waling MM, Adhin AA, van Daele PLA, Schreurs MWJ, Rombach SM. The value of anti-neutrophil cytoplasmic antibodies (ANCA) testing for the diagnosis of ANCA-associated vasculitis, a systematic review and meta-analysis. Autoimmun Rev 2021;20:102716.
Mahr A, Guillevin L, Poissonnet M, Aymé S. Prevalences of polyarteritis nodosa, microscopic polyangiitis, Wegener’s granulomatosis, and Churg-Strauss syndrome in a French urban multiethnic population in 2000: A capture-recapture estimate. Arthritis Rheum 2004;51:92–9.
Scott DG, Watts RA. Systemic vasculitis: Epidemiology, classification and environmental factors. Ann Rheum Dis 2000;59:161–3.
Pearce FA, Hubbard RB, Grainge MJ, Watts RA, Abhishek A, Lanyon PC. Can granulomatosis with polyangiitis be diagnosed earlier in primary care? A case-control study. QJM 2018;111:39–45.
Steinberg AW, Wechsler ME, Fernández Pérez ER. Trends in antineutrophil cytoplasmic autoantibody-associated vasculitis-related mortality in the United States, 1999 to 2017. Ann Intern Med 2020;172:160–3.
Luqmani R, Suppiah R, Edwards CJ, Phillip R, Maskell J, Culliford D, et al. Mortality in Wegener’s granulomatosis: A bimodal pattern. Rheumatology (Oxford) 2011;50:697–702.
Tan JA, Choi HK, Xie H, Sayre EC, Esdaile JM, Aviña-Zubieta JA. All-cause and cause-specific mortality in patients with granulomatosis with polyangiitis: A population-based study. Arthritis Care Res 2019;71:155–63.
Iannella G, Greco A, Granata G, Manno A, Pasquariello B, Angeletti D, et al. Granulomatosis with polyangiitis and facial palsy: Literature review and insight in the autoimmune pathogenesis. Autoimmun Rev 2016;15:621–31.
Martinez Del Pero M, Rasmussen N, Chaudhry A, Jani P, Jayne D. Structured clinical assessment of the ear, nose and throat in patients with granulomatosis with polyangiitis (Wegener’s). Eur Arch Otorhinolaryngol 2013;270:345–54.
Morales-Angulo C, García-Zornoza R, Obeso-Agüera S, Calvo-Alén J, González-Gay MA. [Ear, nose and throat manifestations of Wegener’s granulomatosis (granulomatosis with polyangiitis)]. Acta Otorrinolaringol Esp 2012;63:206–11.
Hoffman GS, Kerr GS, Leavitt RY, Hallahan CW, Lebovics RS, Travis WD, et al. Wegener granulomatosis: An analysis of 158 patients. Ann Intern Med 1992;116:488–98.
Reinhold-Keller E, Beuge N, Latza U, de Groot K, Rudert H, Nölle B, et al. An interdisciplinary approach to the care of patients with Wegener’s granulomatosis: Long-term outcome in 155 patients. Arthritis Rheum 2000;43:1021–32.
Felicetti M, Cazzador D, Padoan R, Pendolino AL, Faccioli C, Nardello E, et al. Ear, nose and throat involvement in granulomatosis with polyangiitis: How it presents and how it determines disease severity and long-term outcomes. Clin Rheumatol 2018;37:1075–83.
Ono N, Niiro H, Ueda A, Sawabe T, Nishizaka H, Furugo I, et al. Characteristics of MPO-ANCA-positive granulomatosis with polyangiitis: A retrospective multi-center study in Japan. Rheumatol Int 2015;35:555–9.
Rahmattulla C, de Lind van Wijngaarden RAF, Berden AE, Hauer HA, Floßmann O, Jayne DRW, et al. Renal function and ear, nose, throat involvement in anti-neutrophil cytoplasmic antibody-associated vasculitis: Prospective data from the European Vasculitis Society clinical trials. Rheumatology 2014;54:899–907.
Bligny D, Mahr A, Toumelin PL, Mouthon L, Guillevin L. Predicting mortality in systemic Wegener’s granulomatosis: A survival analysis based on 93 patients. Arthritis Rheum 2004;51:83–91.
Holle JU, Gross WL, Holl-Ulrich K, Ambrosch P, Noelle B, Both M, et al. Prospective long-term follow-up of patients with localised Wegener’s granulomatosis: Does it occur as persistent disease stage? Ann Rheum Dis 2010;69:1934–9.
Srouji IA, Andrews P, Edwards C, Lund VJ. Patterns of presentation and diagnosis of patients with Wegener’s granulomatosis: ENT aspects. J Laryngol Otol 2007;121:653–8.
Kornblut AD, Wolff SM, deFries HO, Fauci AS. Wegener’s granulomatosis. Laryngoscope 1980;90:1453–65.
Safavi Naini A, Ghorbani J, Montazer Lotfe Elahi S, Beigomi M. Otologic manifestations and progression in patients with Wegener’s granulomatosis: A survey in 55 patients. Iran J Otorhinolaryngol 2017;29:327–31.
Bakthavachalam S, Driver MS, Cox C, Spiegel JH, Grundfast KM, Merkel PA. Hearing loss in Wegener’s granulomatosis. Otol Neurotol 2004;25:833–7.
Greco A, Marinelli C, Fusconi M, Macri GF, Gallo A, De Virgilio A, et al. Clinic manifestations in granulomatosis with polyangiitis. Int J Immunopathol Pharmacol 2016;29:151–9.
Coordes A, Loose SM, Hofmann VM, Hamilton GS 3rd, Riedel F, Menger DJ, et al. Saddle nose deformity and septal perforation in granulomatosis with polyangiitis. Clin Otolaryngol 2018;43:291–9.
Yoshida N, Iino Y. Pathogenesis and diagnosis of otitis media with ANCA-associated vasculitis. Allergol Int 2014;63:523–32.
Erickson VR, Hwang PH. Wegener’s granulomatosis: Current trends in diagnosis and management. Curr Opin Otolaryngol Head Neck Surg 2007;15:170–6.
Ferri E, Armato E, Capuzzo P, Cavaleri S, Ianniello F. Early diagnosis of Wegener’s granulomatosis presenting with bilateral facial paralysis and bilateral serous otitis media. Auris Nasus Larynx 2007;34:379–82.
Magliulo G, Parrotto D, Alla F, Gagliardi S. Acute bilateral facial palsy and Wegener’s disease. Otolaryngol Head Neck Surg 2008;139:476–7.
Nikolaou AC, Vlachtsis KC, Daniilidis MA, Petridis DG, Daniilidis IC. Wegener’s granulomatosis presenting with bilateral facial nerve palsy. Eur Arch Otorhinolaryngol 2001;258:198–202.
Roszkowska A, Morawska-Kochman M, Temporale H, Sikorska-Żuk M, Kręcicki T. Bilateral facial palsy in rapidly progressive course of Wegener’s granulomatosis: A case report. Case Rep Otolaryngol 2013;2013:875108.
Mori A, Hira K, Hatano T, Okuma Y, Kubo S, Hirano K, et al. Bilateral facial nerve palsy due to otitis media associated with myeloperoxidase-antineutrophil cytoplasmic antibody. Am J Med Sci 2013;346:240–3.
Holle JU, Gross WL. Neurological involvement in Wegener’s granulomatosis. Curr Opin Rheumatol 2011;23:7–11.
Merkel P. Overview of and approach to the vasculitides in adults: Uptodate; 2021.
D’Anza B, Langford CA, Sindwani R. Sinonasal imaging findings in granulomatosis with polyangiitis (Wegener granulomatosis): A systematic review. Am J Rhinol Allergy 2017;31:16–21.
Pakalniskis MG, Berg AD, Policeni BA, Gentry LR, Sato Y, Moritani T, et al. The many faces of granulomatosis with polyangiitis: A review of the head and neck imaging manifestations. Am J Roentgenol 2015;205:W619–29.
Benoudiba F, Marsot-Dupuch K, Rabia MH, Cabanne J, Bobin S, Lasjaunias P. Sinonasal Wegener’s granulomatosis: CT characteristics. Neuroradiology 2003;45:95–9.
Robson JC, Grayson PC, Ponte C, Suppiah R, Craven A, Judge A, et al. 2022 American College of Rheumatology/European Alliance of Associations for Rheumatology classification criteria for granulomatosis with polyangiitis. Ann Rheum Dis 2022;81:315–20.
Devaney KO, Travis WD, Hoffman G, Leavitt R, Lebovics R, Fauci AS. Interpretation of head and neck biopsies in Wegener’s granulomatosis. A pathologic study of 126 biopsies in 70 patients. Am J Surg Pathol 1990;14:555–64.
Masiak A, Zdrojewski Z, Pęksa R, Smoleńska Ż, Czuszyńska Z, Siemińska A, et al. The usefulness of histopathological examinations of non-renal biopsies in the diagnosis of granulomatosis with polyangiitis. Reumatologia 2017;55:230–6.
Maguchi S, Fukuda S, Takizawa M. Histological findings in biopsies from patients with cytoplasmic-antineutrophil cytoplasmic antibody (cANCA)-positive Wegener’s granulomatosis. Auris Nasus Laryn×2001;28(Suppl):S53–8.
Pendolino AL, Unadkat S, Zhang H, Pendolino M, Bianchi G, Randhawa PS, et al. The role of surgery in antineutrophil cytoplasmic antibody-associated vasculitides affecting the nose and sinuses: A systematic review. SAGE Open Med 2020;8:2050312120936731.
Hegazy M, Ahmed H, Eltelety A. ENT manifestations of Granulomatosis with polyangiitis. Vessel Plus 2021. doi: 10.20517/2574-1209.2021.52.
Chung SA, Langford CA, Maz M, Abril A, Gorelik M, Guyatt G, et al. 2021 American College of Rheumatology/Vasculitis Foundation Guideline for the management of antineutrophil cytoplasmic antibody-associated vasculitis. Arthritis Rheumatol 2021;73:1366–83.
Gopaluni S, Flossmann O, Little MA, O’Hara P, Bekker P, Jayne D. Effect of disease activity at three and six months after diagnosis on long-term outcomes in antineutrophil cytoplasmic antibody-associated vasculitis. Arthritis Rheumatol 2019;71:784–91.
Harvey RJ, Snidvongs K, Kalish LH, Oakley GM, Sacks R. Corticosteroid nasal irrigations are more effective than simple sprays in a randomized double-blinded placebo-controlled trial for chronic rhinosinusitis after sinus surgery. Int Forum Allergy Rhinol 2018;8:461–70.
Coates ML, Willcocks LC, Sivasothy P, Martinez Del Pero M. Ear, nose, throat and airways disease in granulomatosis with polyangiitis. Rheumatology (Oxford) 2021;60(Suppl 3):iii50-3.
Kühn D, Hospowsky C, Both M, Hey M, Laudien M. Manifestation of granulomatosis with polyangiitis in head and neck. Clin Exp Rheumatol 2018;36(Suppl 111):78–84.
Sachse F, Stoll W. Nasal surgery in patients with systemic disorders. GMS Curr Top Otorhinolaryngol Head Neck Surg 2010;9:Doc02.
Congdon D, Sherris DA, Specks U, McDonald T. Long-term follow-up of repair of external nasal deformities in patients with Wegener’s granulomatosis. Laryngoscope 2002;112:731–7.
Ezzat WH, Compton RA, Basa KC, Levi J. Reconstructive techniques for the saddle nose deformity in granulomatosis with polyangiitis: A systematic review. JAMA Otolaryngol Head Neck Surg 2017;143:507–12.
Rasmussen N. Management of the ear, nose, and throat manifestations of Wegener granulomatosis: An otorhinolaryngologist’s perspective. Curr Opin Rheumatol 2001;13:3–11.
Gubbels SP, Barkhuizen A, Hwang PH. Head and neck manifestations of Wegener’s granulomatosis. Otolaryngol Clin North Am 2003;36:685–705.
Fokkens WJ, Lund VJ, Hopkins C, Hellings PW, Kern R, Reitsma S, et al. European position paper on rhinosinusitis and nasal polyps 2020. Rhinology 2020;58(Suppl S29):1–464.
Kwame I PC, Andrews P. Surgery for vasculitic disease of the nose and sinuses. Int J Head Neck Surg 2018;9:1–6.
Redaelli de Zinis LO, Gamba P, Balzanelli C. Acute otitis media and facial nerve paralysis in adults. Otol Neurotol 2003;24:113–7.
Hern JD, Hollis LJ, Mochloulis G, Montgomery PQ, Tolley NS. Early diagnosis of Wegener’s granulomatosis presenting with facial nerve palsy. J Laryngol Otol 1996;110:459–61.
Wawrzecka A, Szymańska A, Jeleniewicz R, Szymański M. Granulomatosis with polyangiitis with bilateral facial palsy and severe mixed hearing loss. Case Rep Otolaryngol 2016;2016:5206170.
Drinias V, Florentzson R. Facial palsy and Wegener’s granulomatosis. Am J Otolaryngol 2004;25:208–12.
Stappaerts I, Van Laer C, Deschepper K, Van de Heyning P, Vermeire P. Endoscopic management of severe subglottic stenosis in Wegener’s granulomatosis. Clin Rheumatol 2000;19:315–7.
Langford CA, Sneller MC, Hallahan CW, Hoffman GS, Kammerer WA, Talar-Williams C, et al. Clinical features and therapeutic management of subglottic stenosis in patients with Wegener’s granulomatosis. Arthritis Rheum 1996;39:1754–60.
Wojciechowska J, Krajewski W, Krajewski P, Kręcicki T. Granulomatosis with polyangiitis in otolaryngologist practice: A review of current knowledge. Clin Exp Otorhinolaryngol 2016;9:8–13.
Girard C, Charles P, Terrier B, Bussonne G, Cohen P, Pagnoux C, et al. Tracheobronchial stenoses in granulomatosis with polyangiitis (Wegener’s): A report on 26 cases. Medicine (Baltimore) 2015;94:e1088.