Are Antibiotics of Value for a Whipple Procedure?

Humans Pancreaticoduodenectomy / adverse effects Surgical Wound Infection / prevention & control Anti-Bacterial Agents / therapeutic use Antibiotic Prophylaxis / methods Cefoxitin / therapeutic use Piperacillin, Tazobactam Drug Combination / therapeutic use
Pancreatoduodenectomy Perioperative antibiotics Piperacillin-tazobactam SSI Surgical prophylaxis Zosyn

Journal

Advances in surgery
ISSN: 1878-0555
Titre abrégé: Adv Surg
Pays: United States
ID NLM: 0045335

Informations de publication

Date de publication:
Sep 2024
Historique:
medline: 2 8 2024
pubmed: 2 8 2024
entrez: 1 8 2024
Statut: ppublish

Résumé

Pancreatoduodenectomy is a complex surgical procedure with a high rate of morbidity, of which surgical-site infections (SSIs) make a large portion. Reduction of SSI rates is critical to decrease hospital lengths of stay, readmissions, delays in adjuvant therapies, and financial health care burden. Current clinical guidelines recommend the administration of cefoxitin as surgical prophylaxis prior to pancreatoduodenectomy. In April 2023, a randomized controlled trial was published in JAMA which showed that piperacillin-tazobactam as perioperative surgical prophylaxis prior to pancreatoduodenectomy decreased 30 day SSI rates (primary outcome), clinically relevant postoperative pancreatic fistula, postoperative sepsis, and Clostridium difficile infection rates.

Identifiants

DOI: 10.1016/j.yasu.2024.04.006 PMID: 39089788
pubmed: 39089788
pii: S0065-3411(24)00006-X
doi: 10.1016/j.yasu.2024.04.006
pii:
doi:

Substances chimiques

Anti-Bacterial Agents 0
Cefoxitin 6OEV9DX57Y
Piperacillin, Tazobactam Drug Combination 157044-21-8

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

79-85

Informations de copyright

Copyright © 2024 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Disclosure The authors have nothing to disclose.

Auteurs

Jonah D Thomas (JD)

Department of Surgery, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA. Electronic address: https://twitter.com/_JonahT.

Carlos Fernández-Del Castillo (CF)

Department of Surgery, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA; GI Cancer Center, Pancreas and Biliary Surgery Program. Electronic address: cfernandez@mgh.harvard.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Are Antibiotics of Value for a Whipple Procedure?
questionsmedicales.fr › Procédures de chirurgie opératoire › Procédures de chirurgie digestive › Duodénopancréatectomie › Are Antibiotics of Value for a Whipple Procedure?
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Complications postopératoires › Infection de plaie opératoire › Are Antibiotics of Value for a Whipple Procedure?
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Are Antibiotics of Value for a Whipple Procedure?
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Prémédication › Antibioprophylaxie › Are Antibiotics of Value for a Whipple Procedure?
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › bêta-Lactames › Céphalosporines › Céfamycines › Céfoxitine › Are Antibiotics of Value for a Whipple Procedure?
questionsmedicales.fr › Préparations pharmaceutiques › Association médicamenteuse › Association de pipéracilline et de tazobactam › Are Antibiotics of Value for a Whipple Procedure?