Digoxin is still useful, but is still causing toxicity.

Digoxin / adverse effects Humans Atrial Fibrillation / drug therapy Heart Failure / chemically induced Cardiotonic Agents / therapeutic use Anti-Arrhythmia Agents / adverse effects

Journal

Cleveland Clinic journal of medicine
ISSN: 1939-2869
Titre abrégé: Cleve Clin J Med
Pays: United States
ID NLM: 8703441

Informations de publication

Date de publication:
01 Aug 2024
Historique:
medline: 2 8 2024
pubmed: 2 8 2024
entrez: 1 8 2024
Statut: epublish

Résumé

Digoxin, the oldest known cardiovascular drug, is still used today to treat heart failure and atrial fibrillation. Because it has a narrow therapeutic index and multiple interactions, it frequently causes toxicity with a wide range of symptoms and cardiac arrhythmias. More importantly, elevated serum digoxin levels have been linked to a higher risk of death in patients with heart failure or atrial fibrillation, even without signs or symptoms of toxicity. This article reviews the current state of digoxin use, its pharmacologic principles, and the mechanisms, clinical presentation, and management of toxicity.

Identifiants

DOI: 10.3949/ccjm.91a.23105 PMID: 39089856
pubmed: 39089856
pii: 91/8/489
doi: 10.3949/ccjm.91a.23105
doi:

Substances chimiques

Digoxin 73K4184T59
Cardiotonic Agents 0
Anti-Arrhythmia Agents 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

489-499

Informations de copyright

Copyright © 2024 The Cleveland Clinic Foundation. All Rights Reserved.

Auteurs

Alejandro Durán Crane (AD)

Cardiovascular Medicine Fellow, Cleveland Clinic, Cleveland, OH.

Michael Militello (M)

Cardiology Clinical Pharmacist, Pharmacotherapy Residency Program Director, Cleveland Clinic, Cleveland, OH.

Michael D Faulx (MD)

Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH; Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH faulxm@ccf.org.

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Classifications MeSH

questionsmedicales.fr › Glucides › Hétérosides › Glucosides cardiotoniques › Glucosides digitaliques › Digoxine › Digoxin is still useful, but is still causing toxicity.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Digoxin is still useful, but is still causing toxicity.
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Troubles du rythme cardiaque › Fibrillation auriculaire › Digoxin is still useful, but is still causing toxicity.
questionsmedicales.fr › Maladies cardiovasculaires › Cardiopathies › Défaillance cardiaque › Digoxin is still useful, but is still causing toxicity.
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Agents protecteurs › Cardiotoniques › Digoxin is still useful, but is still causing toxicity.
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents cardiovasculaires › Antiarythmiques › Digoxin is still useful, but is still causing toxicity.