Tregs delivered post-myocardial infarction adopt an injury-specific phenotype promoting cardiac repair via macrophages in mice.
Animals
Myocardial Infarction
/ immunology
T-Lymphocytes, Regulatory
/ immunology
Macrophages
/ immunology
Male
Mice
Interleukin-10
/ metabolism
Mice, Inbred C57BL
Phenotype
Myocardium
/ pathology
Monocytes
/ immunology
Myocytes, Cardiac
/ metabolism
Fibrosis
CD8-Positive T-Lymphocytes
/ immunology
Disease Models, Animal
Mice, Knockout
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
01 Aug 2024
01 Aug 2024
Historique:
received:
30
10
2023
accepted:
22
07
2024
medline:
2
8
2024
pubmed:
2
8
2024
entrez:
1
8
2024
Statut:
epublish
Résumé
Regulatory T cells (Tregs) are key immune regulators that have shown promise in enhancing cardiac repair post-MI, although the mechanisms remain elusive. Here, we show that rapidly increasing Treg number in the circulation post-MI via systemic administration of exogenous Tregs improves cardiac function in male mice, by limiting cardiomyocyte death and reducing fibrosis. Mechanistically, exogenous Tregs quickly home to the infarcted heart and adopt an injury-specific transcriptome that mediates repair by modulating monocytes/macrophages. Specially, Tregs lead to a reduction in pro-inflammatory Ly6C
Identifiants
pubmed: 39090108
doi: 10.1038/s41467-024-50806-y
pii: 10.1038/s41467-024-50806-y
doi:
Substances chimiques
Interleukin-10
130068-27-8
IL10 protein, mouse
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
6480Subventions
Organisme : Department of Health | National Health and Medical Research Council (NHMRC)
ID : APP1176213
Organisme : Department of Health | National Health and Medical Research Council (NHMRC)
ID : APP1176213
Organisme : Department of Health | National Health and Medical Research Council (NHMRC)
ID : APP1202105
Informations de copyright
© 2024. The Author(s).
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