Sequence-specific nanoparticle barcode strategy for multiplex human enterovirus typing.


Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
01 Aug 2024
Historique:
received: 02 11 2023
accepted: 23 07 2024
medline: 2 8 2024
pubmed: 2 8 2024
entrez: 1 8 2024
Statut: epublish

Résumé

Human enteroviruses (HEV) can cause a range of diseases from mild to potentially life-threatening. Identification and genotyping of HEV are crucial for disease management. Existing typing methods, however, have inherent limitations. Developing alternative methods to detect HEV with more virus types, high accuracy, and sensitivity in an accessible manner presents a technological and analytical challenge. Here, a sequence-specific nanoparticle barcode (SSNB) method is presented for simultaneous detection of 10 HEV types. This method significantly increases sensitivity, enhancing detection by 10-10

Identifiants

pubmed: 39090126
doi: 10.1038/s41467-024-50921-w
pii: 10.1038/s41467-024-50921-w
doi:

Substances chimiques

RNA, Viral 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

6478

Informations de copyright

© 2024. The Author(s).

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Auteurs

Zecheng Zhong (Z)

State Key Laboratory of Vaccines for Infectious Diseases, School of Public Health, Xiamen University, Xiamen, 361102, Fujian, China.
NMPA Key Laboratory for Research and Evaluation of Infectious Disease Diagnostic Technology, School of Public Health, Xiamen University, Xiamen, 361102, Fujian, China.
Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, 361102, Fujian, China.

Xiaosong Su (X)

Zhongshan Hospital Fudan University Xiamen Branch, Xiamen, 361015, Fujian, China.

Kunyu Yang (K)

State Key Laboratory of Vaccines for Infectious Diseases, School of Public Health, Xiamen University, Xiamen, 361102, Fujian, China.
NMPA Key Laboratory for Research and Evaluation of Infectious Disease Diagnostic Technology, School of Public Health, Xiamen University, Xiamen, 361102, Fujian, China.
Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, 361102, Fujian, China.

Weida Huang (W)

State Key Laboratory of Vaccines for Infectious Diseases, School of Public Health, Xiamen University, Xiamen, 361102, Fujian, China.
NMPA Key Laboratory for Research and Evaluation of Infectious Disease Diagnostic Technology, School of Public Health, Xiamen University, Xiamen, 361102, Fujian, China.
Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, 361102, Fujian, China.

Jin Wang (J)

State Key Laboratory of Vaccines for Infectious Diseases, School of Public Health, Xiamen University, Xiamen, 361102, Fujian, China.
NMPA Key Laboratory for Research and Evaluation of Infectious Disease Diagnostic Technology, School of Public Health, Xiamen University, Xiamen, 361102, Fujian, China.
Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, 361102, Fujian, China.

Zhihao Zhuo (Z)

State Key Laboratory of Vaccines for Infectious Diseases, School of Public Health, Xiamen University, Xiamen, 361102, Fujian, China.
NMPA Key Laboratory for Research and Evaluation of Infectious Disease Diagnostic Technology, School of Public Health, Xiamen University, Xiamen, 361102, Fujian, China.
Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, 361102, Fujian, China.

Jiyu Xiang (J)

State Key Laboratory of Vaccines for Infectious Diseases, School of Public Health, Xiamen University, Xiamen, 361102, Fujian, China.
NMPA Key Laboratory for Research and Evaluation of Infectious Disease Diagnostic Technology, School of Public Health, Xiamen University, Xiamen, 361102, Fujian, China.
Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, 361102, Fujian, China.

Lesi Lin (L)

State Key Laboratory of Vaccines for Infectious Diseases, School of Public Health, Xiamen University, Xiamen, 361102, Fujian, China.
NMPA Key Laboratory for Research and Evaluation of Infectious Disease Diagnostic Technology, School of Public Health, Xiamen University, Xiamen, 361102, Fujian, China.
Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, 361102, Fujian, China.
School of Life Sciences, Xiamen University, Xiamen, 361102, Fujian, China.

Shuizhen He (S)

Xiamen Haicang Hospital, Haiyu Road, Xiamen, 361026, Fujian, China.

Tingdong Li (T)

State Key Laboratory of Vaccines for Infectious Diseases, School of Public Health, Xiamen University, Xiamen, 361102, Fujian, China.
NMPA Key Laboratory for Research and Evaluation of Infectious Disease Diagnostic Technology, School of Public Health, Xiamen University, Xiamen, 361102, Fujian, China.
Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, 361102, Fujian, China.
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, National Innovation Platform for Industry-Education Integration in Vaccine Research, Xiamen University, Xiamen, 361102, Fujian, China.

Jun Zhang (J)

State Key Laboratory of Vaccines for Infectious Diseases, School of Public Health, Xiamen University, Xiamen, 361102, Fujian, China.
NMPA Key Laboratory for Research and Evaluation of Infectious Disease Diagnostic Technology, School of Public Health, Xiamen University, Xiamen, 361102, Fujian, China.
Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, 361102, Fujian, China.
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, National Innovation Platform for Industry-Education Integration in Vaccine Research, Xiamen University, Xiamen, 361102, Fujian, China.

Shengxiang Ge (S)

State Key Laboratory of Vaccines for Infectious Diseases, School of Public Health, Xiamen University, Xiamen, 361102, Fujian, China. sxge@xmu.edu.cn.
NMPA Key Laboratory for Research and Evaluation of Infectious Disease Diagnostic Technology, School of Public Health, Xiamen University, Xiamen, 361102, Fujian, China. sxge@xmu.edu.cn.
Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, 361102, Fujian, China. sxge@xmu.edu.cn.
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, National Innovation Platform for Industry-Education Integration in Vaccine Research, Xiamen University, Xiamen, 361102, Fujian, China. sxge@xmu.edu.cn.

Shiyin Zhang (S)

State Key Laboratory of Vaccines for Infectious Diseases, School of Public Health, Xiamen University, Xiamen, 361102, Fujian, China. zhangshiyin@xmu.edu.cn.
NMPA Key Laboratory for Research and Evaluation of Infectious Disease Diagnostic Technology, School of Public Health, Xiamen University, Xiamen, 361102, Fujian, China. zhangshiyin@xmu.edu.cn.
Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, 361102, Fujian, China. zhangshiyin@xmu.edu.cn.
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, National Innovation Platform for Industry-Education Integration in Vaccine Research, Xiamen University, Xiamen, 361102, Fujian, China. zhangshiyin@xmu.edu.cn.

Ningshao Xia (N)

State Key Laboratory of Vaccines for Infectious Diseases, School of Public Health, Xiamen University, Xiamen, 361102, Fujian, China. nsxia@xmu.edu.cn.
NMPA Key Laboratory for Research and Evaluation of Infectious Disease Diagnostic Technology, School of Public Health, Xiamen University, Xiamen, 361102, Fujian, China. nsxia@xmu.edu.cn.
Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, 361102, Fujian, China. nsxia@xmu.edu.cn.
School of Life Sciences, Xiamen University, Xiamen, 361102, Fujian, China. nsxia@xmu.edu.cn.
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, National Innovation Platform for Industry-Education Integration in Vaccine Research, Xiamen University, Xiamen, 361102, Fujian, China. nsxia@xmu.edu.cn.

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