A melanin-like polymer bearing phenylboronic units as a suitable bioplatform for living cell display technology.
Boronic acid
Living materials
Organic biopolymers
Organic coatings
Polydopamine
Polysaccharides
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
01 Aug 2024
01 Aug 2024
Historique:
received:
21
05
2024
accepted:
30
07
2024
medline:
2
8
2024
pubmed:
2
8
2024
entrez:
1
8
2024
Statut:
epublish
Résumé
Surface display of functional groups with specific reactivity around living cells is an emerging, low cost and highly eco-compatible technology that serves multiple applications, ranging from basic biochemical studies to biomedicine, therapeutics and environmental sciences. Conversely to classical methods exploiting hazardous organic synthesis of precursors or monovalent functionalization via genetics, here we perform functional decoration of individual living microalgae using suitable biocoatings based on polydopamine, a melanin-like synthetic polymer. Here we demonstrate the one-pot synthesis of a functional polydopamine bearing phenylboronic units which can decorate the living cell surfaces via a direct ester formation between boronic units and surface glycoproteins. Furthermore, biosorption of fluorescent sugars on functionalized cell membranes is triggered, demonstrating that these organic coatings act as biocompatible soft shells, still functional and reactive after cell engineering.
Identifiants
pubmed: 39090178
doi: 10.1038/s41598-024-68932-4
pii: 10.1038/s41598-024-68932-4
doi:
Substances chimiques
Polymers
0
polydopamine
0
Melanins
0
Indoles
0
Boronic Acids
0
benzeneboronic acid
L12H7B02G5
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
17856Informations de copyright
© 2024. The Author(s).
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