Concurrent genotyping and expression of NLRP3 inflammasome in pityriasis versicolor patient's skin lesions.
Humans
Tinea Versicolor
/ diagnosis
NLR Family, Pyrin Domain-Containing 3 Protein
/ genetics
Female
Polymorphism, Single Nucleotide
Male
Case-Control Studies
Adult
Inflammasomes
/ genetics
Skin
/ pathology
Genotype
Malassezia
/ isolation & purification
Young Adult
Genetic Predisposition to Disease
Middle Aged
Alleles
Adolescent
ELISA
NLRP3
Pityriasis versicolor
Q 705 K
Real time-PCR
rs35829419
Journal
Archives of dermatological research
ISSN: 1432-069X
Titre abrégé: Arch Dermatol Res
Pays: Germany
ID NLM: 8000462
Informations de publication
Date de publication:
02 Aug 2024
02 Aug 2024
Historique:
received:
30
05
2024
accepted:
06
07
2024
revised:
05
07
2024
medline:
2
8
2024
pubmed:
2
8
2024
entrez:
2
8
2024
Statut:
epublish
Résumé
The goal of this study is to investigate the impact of the rs35829419 SNP on the serum level of NLRP3, and to assess the relationship between NLRP3 and its SNP and vulnerability to Pityriasis versicolor. Pityriasis versicolor (PV) is one of the most frequent skin conditions linked to skin pigmentation changes. Malassezia plays a key role in the pathogenesis of PV. A case-control study, 50 patients with pityriasis versicolor and 44 healthy controls. Real-time PCR was used to genotype NLRP3 (rs35829419) and ELISA assay of NLRP3 levels in tissue samples. There was a significantly higher median NLPR3 levels in PV patients than controls. A significant predominance of A allele of Q 705 K was in patients than controls. The risk of having the disease in the presence of A allele is nearly 10 times than having C allele. In PV patients, there was a significant relationship between NLPR3 levels and Q 705 K genotypes with higher NLPR3 levels in AA genotype. A potential correlation between PV and the Q705K polymorphism, pointing to evidence of NLRP3 alteration in PV patients. The NLRP3 inflammasome may be an appropriate therapeutic target for Malassezia-associated skin disorders.
Identifiants
pubmed: 39093484
doi: 10.1007/s00403-024-03221-8
pii: 10.1007/s00403-024-03221-8
doi:
Substances chimiques
NLR Family, Pyrin Domain-Containing 3 Protein
0
NLRP3 protein, human
0
Inflammasomes
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
501Informations de copyright
© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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