Treating Seizures and Improving Newborn Outcomes for Infants with Hypoxic-Ischemic Encephalopathy.

Humans Hypoxia-Ischemia, Brain / therapy Infant, Newborn Anticonvulsants / therapeutic use Seizures / drug therapy Phenobarbital / therapeutic use Electroencephalography
EEG Epilepsy Neurocritical care Phenobarbital Seizure

Journal

Clinics in perinatology
ISSN: 1557-9840
Titre abrégé: Clin Perinatol
Pays: United States
ID NLM: 7501306

Informations de publication

Date de publication:
Sep 2024
Historique:
medline: 3 8 2024
pubmed: 3 8 2024
entrez: 2 8 2024
Statut: ppublish

Résumé

Hypoxic-ischemic encephalopathy is the most common cause of neonatal seizures. Continuous electroencephalographic monitoring is recommended given high rates of subclinical seizures. Prompt diagnosis and treatment of seizures may improve neurodevelopmental outcomes. International League Against Epilepsy guidelines indicate that (1) phenobarbital remains the first-line treatment of neonatal seizures and (2) early discontinuation of antiseizure medications following resolution of acute provoked seizures, and prior to discharge home, is recommended. Long-term follow-up of these infants is necessary to screen for postneonatal epilepsy and support neurodevelopment.

Identifiants

DOI: 10.1016/j.clp.2024.04.013 PMID: 39095097
pubmed: 39095097
pii: S0095-5108(24)00052-6
doi: 10.1016/j.clp.2024.04.013
pii:
doi:

Substances chimiques

Anticonvulsants 0
Phenobarbital YQE403BP4D

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

573-586

Informations de copyright

Copyright © 2024 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Disclosure Dr R.A. Shellhaas receives royalties from UpToDate for authorship of topics related to neonatal seizures; serves as a consultant for the Epilepsy Study Consortium; and receives a stipend for her role as president-elect of the Pediatric Epilepsy Research Foundation. Drs H.C. Glass, T. Anwar, R.L. Triplett, and A. Ahmed have nothing to disclose.

Auteurs

Tayyba Anwar (T)

Department of Neurology, Children's National Hospital, 111 Michigan Avenue Northwest, Washington, DC 20010, USA.

Regina L Triplett (RL)

Department of Neurology, Washington University in St Louis, 1 Brookings Drive, Saint Louis, MO 63130, USA.

Afaf Ahmed (A)

Division of Pediatric and Developmental Neurology, Department of Neurology, Washington University in St Louis, 1 Brookings Drive, Saint Louis, MO 63130, USA.

Hannah C Glass (HC)

Department of Neurology, University of California San Francisco, 500 Parnassus Avenue, San Francisco, CA 94143, USA.

Renée A Shellhaas (RA)

Department of Neurology, Washington University in St Louis, MSC 8091-29-12400, 660 South Euclid Avenue, Saint Louis, MO 63110, USA. Electronic address: rshellhaas@wustl.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Treating Seizures and Improving Newborn...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Signes et symptômes respiratoires › Hypoxie › Hypoxie cérébrale › Hypoxie-ischémie du cerveau › Treating Seizures and Improving Newborn...
questionsmedicales.fr › Personnes › Tranches d'âge › Nourrisson › Nouveau-né › Treating Seizures and Improving Newborn...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Anticonvulsivants › Treating Seizures and Improving Newborn...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations neurologiques › Crises épileptiques › Treating Seizures and Improving Newborn...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyrimidines › Pyrimidinones › Barbituriques › Phénobarbital › Treating Seizures and Improving Newborn...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Électrodiagnostic › Électroencéphalographie › Treating Seizures and Improving Newborn...