CD44 signaling in Müller cells impacts photoreceptor function and survival in healthy and diseased retinas.
CD44
Gliosis
Glutamate
Inflammation
Müller cells
Retinitis pigmentosa
SLC1A2
Journal
Journal of neuroinflammation
ISSN: 1742-2094
Titre abrégé: J Neuroinflammation
Pays: England
ID NLM: 101222974
Informations de publication
Date de publication:
02 Aug 2024
02 Aug 2024
Historique:
received:
29
04
2024
accepted:
15
07
2024
medline:
3
8
2024
pubmed:
3
8
2024
entrez:
2
8
2024
Statut:
epublish
Résumé
Retinitis pigmentosa (RP), an inherited retinal disease, affects 1,5 million people worldwide. The initial mutation-driven photoreceptor degeneration leads to chronic inflammation, characterized by Müller cell activation and upregulation of CD44. CD44 is a cell surface transmembrane glycoprotein and the primary receptor for hyaluronic acid. It is involved in many pathological processes, but little is known about CD44's retinal functions. CD44 expression is also increased in Müller cells from our Pde6b
Identifiants
pubmed: 39095775
doi: 10.1186/s12974-024-03175-8
pii: 10.1186/s12974-024-03175-8
doi:
Substances chimiques
Hyaluronan Receptors
0
Cd44 protein, mouse
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
190Informations de copyright
© 2024. The Author(s).
Références
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