Association of serum 25-hydroxy vitamin D status with cardiometabolic risk factors and total and regional obesity in southern Iran: evidence from the PoCOsteo study.
Body fat distribution
Cardiometabolic
Obesity
Vitamin D
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
03 Aug 2024
03 Aug 2024
Historique:
received:
13
12
2023
accepted:
29
07
2024
medline:
4
8
2024
pubmed:
4
8
2024
entrez:
3
8
2024
Statut:
epublish
Résumé
Cardiometabolic risk factors increase the chance of developing cardiovascular disease (CVD) and type 2 diabetes. Most CVD risk factors are influenced by total and regional obesity. A higher risk of developing CVD may be linked to vitamin D deficiency, which is more prevalent in the older population. With the goal of evaluating the association between vitamin D and cardiometabolic risk factors and total and regional obesity in older adults, this research included 25 (OH) vitamin D3 concentrations and biochemical markers associated with cardiometabolic diseases, as well as total and regional adiposity, which was measured by DXA. A total of 1991 older participants in the PoCOsteo study were included. Overall, 38.5% of participants had vitamin D deficiency. After adjusting for confounders, the results of multiple linear and logistic regression suggested an inverse association between vitamin D and body mass index (P = 0.04), waist circumference (P = 0.001), total fat (P = 0.02), android fat (P = 0.001), visceral fat (P < 0.001), subcutaneous fat (P = 0.01), trunk fat (P = 0.006), arm fat (P = 0.03), high systolic blood pressure (P = 0.004), high total cholesterol (P < 0.001), high LDL-cholesterol (P < 0.001), high serum triglycerides (P = 0.001), and high fasting glucose (P < 0.001). Additionally, higher vitamin D concentrations decreased the risk of dyslipidemia by 2%. Our results showed a significant association between serum vitamin D and a number of cardiometabolic risk factors, including total and regional obesity.
Identifiants
pubmed: 39097599
doi: 10.1038/s41598-024-68773-1
pii: 10.1038/s41598-024-68773-1
doi:
Substances chimiques
Vitamin D
1406-16-2
25-hydroxyvitamin D
A288AR3C9H
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
17983Informations de copyright
© 2024. The Author(s).
Références
Després, J. P. & Lemieux, I. Abdominal obesity and metabolic syndrome. Nature. 444(7121), 881–887 (2006).
pubmed: 17167477
doi: 10.1038/nature05488
Leiter, L. A. et al. Cardiometabolic risk in Canada: A detailed analysis and position paper by the cardiometabolic risk working group. Can. J. Cardiol. 27(2), e1–e33 (2011).
pubmed: 21459257
doi: 10.1016/j.cjca.2010.12.054
Mezhal, F. et al. High prevalence of cardiometabolic risk factors amongst young adults in the United Arab Emirates: The UAE Healthy Future Study. BMC Cardiovasc. Disord. 23(1), 137 (2023).
pubmed: 36922773
pmcid: 10015775
doi: 10.1186/s12872-023-03165-3
Nichols, G. A. et al. Cardiometabolic risk factors among 1.3 million adults with overweight or obesity, but not diabetes, in 10 geographically diverse regions of the United States, 2012–2013. Prev. Chronic Dis. 14, 22 (2017).
doi: 10.5888/pcd14.160438
Brown, J. C., Gerhardt, T. E., Kwon, E. Risk Factors for Coronary Artery Disease (StatPearls Publishing LLC., 2023).
Lavie, C. J. et al. Healthy weight and obesity prevention: JACC health promotion series. J. Am. Coll. Cardiol. 72(13), 1506–1531 (2018).
pubmed: 30236314
doi: 10.1016/j.jacc.2018.08.1037
Roth, G. A. et al. Global burden of cardiovascular diseases and risk factors, 1990–2019: Update from the GBD 2019 study. J. Am. Coll. Cardiol. 76(25), 2982–3021 (2020).
pubmed: 33309175
pmcid: 7755038
doi: 10.1016/j.jacc.2020.11.010
Chauhan, K., Shahrokhi, M. & Huecker, M. R. Vitamin D (StatPearls Publishing LLC, 2023).
Amirkhizi, F., Khademi, Z., Hamedi Shahraki, S. & Rahimlou, M. Vitamin D insufficiency and its association with adipokines and atherogenic indices in patients with metabolic syndrome: A case-control study. Front. Endocrinol. (Lausanne). 14, 1080138 (2023).
pubmed: 36742396
pmcid: 9895380
doi: 10.3389/fendo.2023.1080138
Ganji, V., Tangpricha, V. & Zhang, X. Serum vitamin D concentration ≥75 nmol/L is related to decreased cardiometabolic and inflammatory biomarkers, metabolic syndrome, and diabetes; and increased cardiorespiratory fitness in US adults. Nutrients. 12(3), 730 (2020).
pubmed: 32164233
pmcid: 7146199
doi: 10.3390/nu12030730
Hajhashemy, Z., Shahdadian, F., Ziaei, R. & Saneei, P. Serum vitamin D levels in relation to abdominal obesity: A systematic review and dose-response meta-analysis of epidemiologic studies. Obes. Rev. 22(2), e13134 (2021).
pubmed: 32881271
doi: 10.1111/obr.13134
Pham, T. M., Ekwaru, J. P., Setayeshgar, S. & Veugelers, P. J. The effect of changing serum 25-hydroxyvitamin D concentrations on metabolic syndrome: A longitudinal analysis of participants of a preventive health program. Nutrients. 7(9), 7271–7284 (2015).
pubmed: 26343719
pmcid: 4586533
doi: 10.3390/nu7095338
Szymczak-Pajor, I., Miazek, K., Selmi, A., Balcerczyk, A. & Śliwińska, A. The action of vitamin D in adipose tissue: Is there the link between vitamin D deficiency and adipose tissue-related metabolic disorders?. Int. J. Mol. Sci. 23(2), 956 (2022).
pubmed: 35055140
pmcid: 8779075
doi: 10.3390/ijms23020956
Wolters, M. et al. Longitudinal associations between vitamin D status and cardiometabolic risk markers among children and adolescents. J. Clin. Endocrinol. Metab. 108, e1731–e1742 (2023).
pubmed: 37261399
doi: 10.1210/clinem/dgad310
Nemeth, Z., Patonai, A., Simon-Szabó, L. & Takács, I. Interplay of vitamin D and SIRT1 in tissue-specific metabolism—Potential roles in prevention and treatment of non-communicable diseases including cancer. Int. J. Mol. Sci. 24(7), 6154 (2023).
pubmed: 37047134
pmcid: 10094444
doi: 10.3390/ijms24076154
Sizar, O., Khare, S., Goyal, A. & Givler, A. Vitamin D deficiency (StatPearls Publishing LLC, 2023).
Palacios, C. & Gonzalez, L. Is vitamin D deficiency a major global public health problem?. J. Steroid Biochem. Mol. Biol. 144(Pt A), 138–145 (2014).
pubmed: 24239505
doi: 10.1016/j.jsbmb.2013.11.003
Lee, S. J. et al. Associations of serum 25-hydroxyvitamin D with metabolic syndrome and its components in elderly men and women: The Korean Urban Rural Elderly cohort study. BMC Geriatr. 19(1), 102 (2019).
pubmed: 30975093
pmcid: 6458686
doi: 10.1186/s12877-019-1118-y
Liu, L. et al. Vitamin D deficiency and metabolic syndrome in elderly Chinese individuals: Evidence from CLHLS. Nutr. Metab. 17(1), 58 (2020).
doi: 10.1186/s12986-020-00479-3
Mutt, S. J. et al. Vitamin D status and components of metabolic syndrome in older subjects from Northern Finland (Latitude 65°North). Nutrients. 11(6), 1229 (2019).
pubmed: 31151163
pmcid: 6628213
doi: 10.3390/nu11061229
Wang, C. M. et al. Inverse relationship between metabolic syndrome and 25-hydroxyvitamin D concentration in elderly people without vitamin D deficiency. Sci. Rep. 8(1), 17052 (2018).
pubmed: 30451913
pmcid: 6242887
doi: 10.1038/s41598-018-35229-2
Joseph, P. et al. Vitamin D supplementation and adverse skeletal and non-skeletal outcomes in individuals at increased cardiovascular risk: Results from the International Polycap Study (TIPS)-3 randomized controlled trial. Nutr. Metab. Cardiovasc. Dis. 33(2), 434–440 (2023).
pubmed: 36604262
doi: 10.1016/j.numecd.2022.11.001
Manson, J. E. et al. Vitamin D supplements and prevention of cancer and cardiovascular disease. N. Engl. J. Med. 380(1), 33–44 (2019).
pubmed: 30415629
doi: 10.1056/NEJMoa1809944
Pittas, A. G. et al. Vitamin D supplementation and prevention of type 2 diabetes. N. Engl. J. Med. 381(6), 520–530 (2019).
pubmed: 31173679
pmcid: 6993875
doi: 10.1056/NEJMoa1900906
Karuppusami, R. et al. Association of serum 25-hydroxy vitamin D with total and regional adiposity and cardiometabolic traits. PLoS One. 15(12), e0243850 (2020).
pubmed: 33370344
pmcid: 7769464
doi: 10.1371/journal.pone.0243850
Mba, C. M. et al. Association between circulating 25-hydroxyvitamin D and cardiometabolic risk factors in adults in rural and urban settings. Nutr. Diabetes. 12(1), 34 (2022).
pubmed: 35906229
pmcid: 9338254
doi: 10.1038/s41387-022-00215-1
Romero-Corral, A. et al. Accuracy of body mass index in diagnosing obesity in the adult general population. Int. J. Obes. (Lond). 32(6), 959–966 (2008).
pubmed: 18283284
pmcid: 2877506
doi: 10.1038/ijo.2008.11
Kim, J. Y., Han, S. H. & Yang, B. M. Implication of high-body-fat percentage on cardiometabolic risk in middle-aged, healthy, normal-weight adults. Obesity (Silver Spring). 21(8), 1571–1577 (2013).
pubmed: 23404833
doi: 10.1002/oby.20020
Lu, Y. C., Lin, Y. C., Yen, A. M. & Chan, W. P. Dual-energy X-ray absorptiometry-assessed adipose tissues in metabolically unhealthy normal weight Asians. Sci. Rep. 9(1), 17698 (2019).
pubmed: 31776349
pmcid: 6881341
doi: 10.1038/s41598-019-53557-9
Shepherd, J. A., Ng, B. K., Sommer, M. J. & Heymsfield, S. B. Body composition by DXA. Bone. 104, 101–105 (2017).
pubmed: 28625918
pmcid: 5659281
doi: 10.1016/j.bone.2017.06.010
Khosravi Shadmani, F., Farzadfar, F., Larijani, B., Mirzaei, M. & Haghdoost, A. A. Trend and projection of mortality rate due to non-communicable diseases in Iran: A modeling study. PLoS One. 14(2), e0211622 (2019).
pubmed: 30763320
pmcid: 6375574
doi: 10.1371/journal.pone.0211622
Marzban, M. et al. Prevalence of vitamin D deficiency and its associated risk factors among rural population of the northern part of the Persian Gulf. BMC Endocr. Disord. 21(1), 219 (2021).
pubmed: 34732181
pmcid: 8565643
doi: 10.1186/s12902-021-00877-5
Shafiee, G. et al. Bushehr Elderly Health (BEH) programme: Study protocol and design of musculoskeletal system and cognitive function (stage II). BMJ Open. 7(8), e013606 (2017).
pubmed: 28780537
pmcid: 5577871
doi: 10.1136/bmjopen-2016-013606
Khashayar, P. et al. Protocol for a multicentre, prospective cohort study of clinical, proteomic and genomic patterns associated with osteoporosis to develop a multidimensional fracture assessment tool: The PoCOsteo Study. BMJ Open. 10(9), e035363 (2020).
pubmed: 32998914
pmcid: 7528352
doi: 10.1136/bmjopen-2019-035363
Aadahl, M. et al. Recent temporal trends in sleep duration, domain-specific sedentary behaviour and physical activity. A survey among 25–79-year-old Danish adults. Scand. J. Public Health. 41(7), 706–711 (2013).
pubmed: 23798478
doi: 10.1177/1403494813493151
Aadahl, M. & Jørgensen, T. Validation of a new self-report instrument for measuring physical activity. Med. Sci. Sports Exerc. 35(7), 1196–1202 (2003).
pubmed: 12840642
doi: 10.1249/01.MSS.0000074446.02192.14
Płudowski, P. et al. Guidelines for preventing and treating vitamin D deficiency: A 2023 update in Poland. Nutrients. 15(3), 695 (2023).
pubmed: 36771403
pmcid: 9920487
doi: 10.3390/nu15030695
Rosen, C. J. Clinical practice. Vitamin D insufficiency. N. Engl. J. Med. 364(3), 248–254 (2011).
pubmed: 21247315
doi: 10.1056/NEJMcp1009570
ElSayed, N. A. et al. 2. Classification and diagnosis of diabetes: Standards of care in diabetes-2023. Diabetes Care. 46(Suppl 1), S19–S40 (2023).
pubmed: 36507649
doi: 10.2337/dc23-S002
Unger, T. et al. 2020 international society of hypertension global hypertension practice guidelines. Hypertension. 75(6), 1334–1357 (2020).
pubmed: 32370572
doi: 10.1161/HYPERTENSIONAHA.120.15026
Miller, M. et al. Triglycerides and cardiovascular disease: A scientific statement from the American Heart Association. Circulation. 123(20), 2292–2333 (2011).
pubmed: 21502576
doi: 10.1161/CIR.0b013e3182160726
Third Report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III) final report. Circulation. 106(25), 3143–3421 (2002).
Rader, D. J., Hoeg, J. M. & Brewer, H. B. Jr. Quantitation of plasma apolipoproteins in the primary and secondary prevention of coronary artery disease. Ann. Intern. Med. 120(12), 1012–1025 (1994).
pubmed: 8185133
doi: 10.7326/0003-4819-120-12-199406150-00008
Boettger, S. F. et al. Prevalence and predictors of vitamin D-deficiency in frail older hospitalized patients. BMC Geriatr. 18(1), 219 (2018).
pubmed: 30236071
pmcid: 6148775
doi: 10.1186/s12877-018-0919-8
Chalcraft, J. R. et al. Vitamin D synthesis following a single bout of sun exposure in older and younger men and women. Nutrients. 12(8), 2237 (2020).
pubmed: 32727044
pmcid: 7468901
doi: 10.3390/nu12082237
Vimaleswaran, K. S. et al. Association of vitamin D status with arterial blood pressure and hypertension risk: A mendelian randomisation study. Lancet Diabetes Endocrinol. 2(9), 719–729 (2014).
pubmed: 24974252
pmcid: 4582411
doi: 10.1016/S2213-8587(14)70113-5
Qi, D., Nie, X. L., Wu, S. & Cai, J. Vitamin D and hypertension: Prospective study and meta-analysis. PLoS One. 12(3), e0174298 (2017).
pubmed: 28358827
pmcid: 5373576
doi: 10.1371/journal.pone.0174298
Jensen, N. S., Wehland, M., Wise, P. M. & Grimm, D. Latest knowledge on the role of vitamin D in hypertension. Int. J. Mol. Sci. 24(5), 4679 (2023).
pubmed: 36902110
pmcid: 10003079
doi: 10.3390/ijms24054679
Vaidya, A. & Forman, J. P. Vitamin D and hypertension: Current evidence and future directions. Hypertension. 56(5), 774–779 (2010).
pubmed: 20937970
doi: 10.1161/HYPERTENSIONAHA.109.140160
Zhang, D. Effect of vitamin D on blood pressure and hypertension in the general population: An update meta-analysis of cohort studies and randomized controlled trials. Prev. Chronic Dis. 17 (2020).
Kunutsor, S. K., Apekey, T. A. & Steur, M. Vitamin D and risk of future hypertension: Meta-analysis of 283,537 participants. Eur. J. Epidemiol. 28, 205–221 (2013).
pubmed: 23456138
doi: 10.1007/s10654-013-9790-2
Cianciolo, G. et al. Vitamin D effects on bone homeostasis and cardiovascular system in patients with chronic kidney disease and renal transplant recipients. Nutrients. 13(5), 1453 (2021).
pubmed: 33922902
pmcid: 8145016
doi: 10.3390/nu13051453
Latic, N. & Erben, R. G. Vitamin D and cardiovascular disease, with emphasis on hypertension, atherosclerosis, and heart failure. Int. J. Mol. Sci. 21(18), 6483 (2020).
pubmed: 32899880
pmcid: 7555466
doi: 10.3390/ijms21186483
Kapil, V. & Gupta, A. K. Solar UV radiation: A potential modifiable risk factor for hypertension. J. Am. Heart Assoc. 9(5), e015627 (2020).
pubmed: 32106745
pmcid: 7335549
doi: 10.1161/JAHA.120.015627
Weller, R. B. et al. Does incident solar ultraviolet radiation lower blood pressure?. J. Am. Heart Assoc. 9(5), e013837 (2020).
pubmed: 32106744
pmcid: 7335547
doi: 10.1161/JAHA.119.013837
Grammatiki, M., Rapti, E., Karras, S., Ajjan, R. A. & Kotsa, K. Vitamin D and diabetes mellitus: Causal or casual association?. Rev. Endocr. Metab. Disord. 18(2), 227–241 (2017).
pubmed: 28062940
doi: 10.1007/s11154-016-9403-y
Mitri, J. & Pittas, A. G. Vitamin D and diabetes. Endocrinol. Metab. Clin. N. Am. 43(1), 205–232 (2014).
doi: 10.1016/j.ecl.2013.09.010
Zhang, Y. et al. Effects of vitamin D supplementation on prevention of type 2 diabetes in patients with prediabetes: A systematic review and meta-analysis. Diabetes Care. 43(7), 1650–1658 (2020).
pubmed: 33534730
doi: 10.2337/dc19-1708
Tang, H. et al. Effects of vitamin D supplementation on glucose and insulin homeostasis and incident diabetes among nondiabetic adults: A meta-analysis of randomized controlled trials. Int. J. Endocrinol. 2018, 7908764 (2018).
pubmed: 30627160
pmcid: 6304827
doi: 10.1155/2018/7908764
Emadzadeh, M. et al. A systematic review and meta-analysis of the effect of Vitamin D-fortified food on glycemic indices. Biofactors. 46(4), 502–513 (2020).
pubmed: 32350957
doi: 10.1002/biof.1632
Pannu, P. K., Piers, L. S., Soares, M. J., Zhao, Y. & Ansari, Z. Vitamin D status is inversely associated with markers of risk for type 2 diabetes: A population based study in Victoria, Australia. PLoS One. 12(6), e0178825 (2017).
pubmed: 28575036
pmcid: 5456387
doi: 10.1371/journal.pone.0178825
Zhang, Y. et al. Effect of vitamin D supplementation on glycemic control in prediabetes: A meta-analysis. Nutrients. 13(12), 4464 (2021).
pubmed: 34960022
pmcid: 8707376
doi: 10.3390/nu13124464
Zoppini, G. et al. Glycated haemoglobin is inversely related to serum vitamin D levels in type 2 diabetic patients. PLoS One. 8(12), e82733 (2013).
pubmed: 24358222
pmcid: 3865107
doi: 10.1371/journal.pone.0082733
Mirhosseini, N., Vatanparast, H., Mazidi, M. & Kimball, S. M. Vitamin D supplementation, glycemic control, and insulin resistance in prediabetics: A meta-analysis. J. Endocr. Soc. 2(7), 687–709 (2018).
pubmed: 29951596
pmcid: 6016617
doi: 10.1210/js.2017-00472
Pittas, A. G. et al. Vitamin D and risk for type 2 diabetes in people with prediabetes: A systematic review and meta-analysis of individual participant data from 3 randomized clinical trials. Ann. Intern. Med. 176(3), 355–363 (2023).
pubmed: 36745886
doi: 10.7326/M22-3018
Sacerdote, A., Dave, P., Lokshin, V. & Bahtiyar, G. Type 2 diabetes mellitus, insulin resistance, and vitamin D. Curr. Diabetes Rep. 19(10), 101 (2019).
doi: 10.1007/s11892-019-1201-y
Kawahara, T. et al. Effect of active vitamin D treatment on development of type 2 diabetes: DPVD randomised controlled trial in Japanese population. BMJ. 377, e066222 (2022).
pubmed: 35613725
pmcid: 9131780
doi: 10.1136/bmj-2021-066222
Md Isa, Z., Amsah, N. & Ahmad, N. The impact of vitamin D deficiency and insufficiency on the outcome of type 2 diabetes mellitus patients: A systematic review. Nutrients. 15(10), 2310 (2023).
pubmed: 37242192
pmcid: 10223393
doi: 10.3390/nu15102310
Surdu, A. M. et al. Vitamin D and its role in the lipid metabolism and the development of atherosclerosis. Biomedicines. 9(2), 172 (2021).
pubmed: 33572397
pmcid: 7916166
doi: 10.3390/biomedicines9020172
Al Refaie, A. et al. Vitamin D and dyslipidemia: Is there really a link? A narrative review. Nutrients. 16(8), 1144 (2024).
pubmed: 38674837
pmcid: 11053479
doi: 10.3390/nu16081144
Huang, X., Yang, Y., Jiang, Y., Zhou, Z. & Zhang, J. Association between vitamin D deficiency and lipid profiles in overweight and obese adults: A systematic review and meta-analysis. BMC Public Health. 23(1), 1653 (2023).
pubmed: 37644450
pmcid: 10464009
doi: 10.1186/s12889-023-16447-4
Dibaba, D. T. Effect of vitamin D supplementation on serum lipid profiles: A systematic review and meta-analysis. Nutr. Rev. 77(12), 890–902 (2019).
pubmed: 31407792
doi: 10.1093/nutrit/nuz037
Lupton, J. R. et al. Deficient serum 25-hydroxyvitamin D is associated with an atherogenic lipid profile: The Very Large Database of Lipids (VLDL-3) study. J. Clin. Lipidol. 10(1), 72-81.e1 (2016).
pubmed: 26892123
doi: 10.1016/j.jacl.2015.09.006
Ganji, V. et al. Serum 25-hydroxyvitamin D concentrations are inversely associated with body adiposity measurements but the association with bone mass is non-linear in postmenopausal women. J. Steroid Biochem. Mol. Biol. 212, 105923 (2021).
pubmed: 34089833
doi: 10.1016/j.jsbmb.2021.105923
Vanlint, S. Vitamin D and obesity. Nutrients. 5(3), 949–956 (2013).
pubmed: 23519290
pmcid: 3705328
doi: 10.3390/nu5030949
Vitezova, A. et al. Vitamin D and body composition in the elderly. Clin. Nutr. 36(2), 585–592 (2017).
pubmed: 27346177
doi: 10.1016/j.clnu.2016.04.017
Karampela, I. et al. Vitamin D and obesity: Current evidence and controversies. Curr. Obes. Rep. 10(2), 162–180 (2021).
pubmed: 33792853
doi: 10.1007/s13679-021-00433-1
Sánchez-López, M. et al. Leg fat might be more protective than arm fat in relation to lipid profile. Eur. J. Nutr. 52(2), 489–495 (2013).
pubmed: 22484387
doi: 10.1007/s00394-012-0350-4
Andreozzi, P. et al. Relationship between vitamin D and body fat distribution evaluated by DXA in postmenopausal women. Nutrition. 32(6), 687–692 (2016).
pubmed: 26856648
doi: 10.1016/j.nut.2015.12.029
Li, H. et al. Central body fat deposits are associated with poor vitamin D status in Chinese children and adolescents. Nutrition. 99–100, 111651 (2022).
pubmed: 35588652
doi: 10.1016/j.nut.2022.111651
Liu, C. A. et al. The relationship between fat distribution in central region and comorbidities in obese people: Based on NHANES 2011–2018. Front. Endocrinol. (Lausanne). 14, 1114963 (2023).
pubmed: 36843589
pmcid: 9945539
doi: 10.3389/fendo.2023.1114963
Yang, Y. et al. Sex differences in the associations between adiposity distribution and cardiometabolic risk factors in overweight or obese individuals: A cross-sectional study. BMC Public Health. 21(1), 1232 (2021).
pubmed: 34174845
pmcid: 8234731
doi: 10.1186/s12889-021-11316-4
Wiklund, P. et al. Abdominal and gynoid fat mass are associated with cardiovascular risk factors in men and women. J. Clin. Endocrinol. Metab. 93(11), 4360–4366 (2008).
pubmed: 18728169
doi: 10.1210/jc.2008-0804
Ao, T., Kikuta, J. & Ishii, M. The effects of vitamin D on immune system and inflammatory diseases. Biomolecules. 11(11), 1624 (2021).
pubmed: 34827621
pmcid: 8615708
doi: 10.3390/biom11111624
Hahn, J. et al. Vitamin D and marine omega 3 fatty acid supplementation and incident autoimmune disease: VITAL randomized controlled trial. BMJ. 376, e066452 (2022).
pubmed: 35082139
pmcid: 8791065
doi: 10.1136/bmj-2021-066452
Mousa, H., Islam, N., Ganji, V. & Zughaier, S. M. Serum 25-hydroxyvitamin D is inversely associated with monocyte percentage to HDL cholesterol ratio among young healthy adults in Qatar. Nutrients. 13(1), 127 (2020).
pubmed: 33396346
pmcid: 7823976
doi: 10.3390/nu13010127
Yin, K. & Agrawal, D. K. Vitamin D and inflammatory diseases. J. Inflamm. Res. 7, 69–87 (2014).
pubmed: 24971027
pmcid: 4070857
Costenbader, K. H. et al. Effects of one year of vitamin D and marine omega-3 fatty acid supplementation on biomarkers of systemic inflammation in older US adults. Clin. Chem. 65(12), 1508–1521 (2019).
pubmed: 31699704
doi: 10.1373/clinchem.2019.306902
Limonte, C. P. et al. Effects of long-term vitamin D and n-3 fatty acid supplementation on inflammatory and cardiac biomarkers in patients with type 2 diabetes: Secondary analyses from a randomised controlled trial. Diabetologia. 64(2), 437–447 (2021).
pubmed: 33098434
doi: 10.1007/s00125-020-05300-7
Dong, Y. et al. Effects of vitamin D(3) and marine omega-3 fatty acids supplementation on biomarkers of systemic inflammation: 4-Year findings from the VITAL randomized trial. Nutrients. 14(24), 5307 (2022).
pubmed: 36558465
pmcid: 9782648
doi: 10.3390/nu14245307
Tangestani, H., Boroujeni, H. K., Djafarian, K., Emamat, H. & Shab-Bidar, S. Vitamin D and the gut microbiota: A narrative literature review. Clin. Nutr. Res. 10(3), 181–191 (2021).
pubmed: 34386438
pmcid: 8331286
doi: 10.7762/cnr.2021.10.3.181
Warmbrunn, M. V. et al. Gut microbiota: A promising target against cardiometabolic diseases. Expert Rev. Endocrinol. Metab. 15(1), 13–27 (2020).
pubmed: 32066294
doi: 10.1080/17446651.2020.1720511
Witkowski, M., Weeks, T. L. & Hazen, S. L. Gut microbiota and cardiovascular disease. Circ. Res. 127(4), 553–570 (2020).
pubmed: 32762536
pmcid: 7416843
doi: 10.1161/CIRCRESAHA.120.316242