Effect of pneumococcal conjugate vaccine six years post-introduction on pneumococcal carriage in Ulaanbaatar, Mongolia.
Pneumococcal Vaccines
/ immunology
Humans
Streptococcus pneumoniae
/ genetics
Infant
Pneumococcal Infections
/ prevention & control
Nasopharynx
/ microbiology
Carrier State
/ epidemiology
Mongolia
/ epidemiology
Cross-Sectional Studies
Vaccines, Conjugate
/ immunology
Female
Male
Serogroup
Prevalence
Serotyping
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
03 Aug 2024
03 Aug 2024
Historique:
received:
25
03
2024
accepted:
24
07
2024
medline:
4
8
2024
pubmed:
4
8
2024
entrez:
3
8
2024
Statut:
epublish
Résumé
Limited data from Asia are available on long-term effects of pneumococcal conjugate vaccine introduction on pneumococcal carriage. Here we assess the impact of 13-valent pneumococcal conjugate vaccine (PCV13) introduction on nasopharyngeal pneumococcal carriage prevalence, density and antimicrobial resistance. Cross-sectional carriage surveys were conducted pre-PCV13 (2015) and post-PCV13 introduction (2017 and 2022). Pneumococci were detected and quantified by real-time PCR from nasopharyngeal swabs. DNA microarray was used for molecular serotyping and to infer genetic lineage (Global Pneumococcal Sequence Cluster). The study included 1461 infants (5-8 weeks old) and 1489 toddlers (12-23 months old) enrolled from family health clinics. We show a reduction in PCV13 serotype carriage (with non-PCV13 serotype replacement) and a reduction in the proportion of samples containing resistance genes in toddlers six years post-PCV13 introduction. We observed an increase in pneumococcal nasopharyngeal density. Serotype 15 A, the most prevalent non-vaccine-serotype in 2022, was comprised predominantly of GPSC904;9. Reductions in PCV13 serotype carriage will likely result in pneumococcal disease reduction. It is important for ongoing surveillance to monitor serotype changes to potentially inform new vaccine development.
Identifiants
pubmed: 39097620
doi: 10.1038/s41467-024-50944-3
pii: 10.1038/s41467-024-50944-3
doi:
Substances chimiques
Pneumococcal Vaccines
0
13-valent pneumococcal vaccine
0
Vaccines, Conjugate
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
6577Subventions
Organisme : GAVI Alliance (Gavi)
ID : PP61690717A2
Informations de copyright
© 2024. The Author(s).
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