Rescue liver transplantation for post-hepatectomy liver failure- single center retrospective analysis.
Complications
Liver failure
Liver resection
Outcomes
Rescue liver transplantation
Journal
BMC surgery
ISSN: 1471-2482
Titre abrégé: BMC Surg
Pays: England
ID NLM: 100968567
Informations de publication
Date de publication:
06 Aug 2024
06 Aug 2024
Historique:
received:
19
01
2024
accepted:
29
07
2024
medline:
7
8
2024
pubmed:
7
8
2024
entrez:
6
8
2024
Statut:
epublish
Résumé
Liver transplantation (LT) is a well-established method applied for the treatment of various liver diseases, including primary and secondary malignancies, as well as acute liver failure triggered by different mechanisms. In turn, liver failure (PHLF) is the most severe complication observed after liver resection (LR). PHLF is an extremely rare indication for LT. The aim of the present study was to assess the results of LT in patients with PHLF. Relevant cases were extracted from the prospectively collected database of all LTs performed in our center. All clinical variables, details of the perioperative course of each patient and long-term follow-up data were thoroughly assessed. Between January 2000 and August 2023, 2703 LTs were carried out. Among them, six patients underwent LT for PHLF, which accounted for 0.2% of all patients. The median age of the patients was 38 years (range 24-66 years). All patients underwent major liver resection before listing for LT. The 90-day mortality after LT was 66.7% (4 out of 6 patients), and all patients experienced complications in the posttransplant course. One patient required early retransplantation due to primary non-function (PNF). The last two transplanted patients are alive at 7 years and 12 months after LT, respectively. In an unselected population of patients with PHLF, LT is a very morbid procedure associated with high mortality but should be considered the only life-saving option in this group.
Identifiants
pubmed: 39107752
doi: 10.1186/s12893-024-02515-y
pii: 10.1186/s12893-024-02515-y
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
224Informations de copyright
© 2024. The Author(s).
Références
Sousa Da Silva RX, Breuer E, Shankar S, Kawakatsu S, Hołówko W, Coelho JS, Jeddou H, Sugiura T, Ghallab M, Da Silva D, Watanabe G, Botea F, Sakai N, Addeo PF, Tzedakis S, Bartsch F, Balcer K, Lim C, Werey F, López V, Montero LP, Claria RS, Leiting J, Vachharajani N, Hopping E, Torres OJM, Hirano S, Andel D, Hagendoorn J, Psica A, Ravaioli M, Ahn KS, Reese T, Montes LA, Gunasekaran G, Alcázar C, Lim JH, Haroon M, Lu Q, Castaldi A, Orimo T, Moeckli B, Abadía T, Ruffolo L, Hasan JD, Ratti F, Kaufmann EF, de Wilde R, Polak WG, Boggi U, Aldrighetti L, McCormack L, Hernandez-Alejandro R, Serrablo A, Toso C, Taketomi A, Gugenheim J, Dong J, Hanif F, Park JS, Ramia JM, Schwartz M, Ramisch D, De Oliveira M, Oldhafer KJ, Kang KJ, Cescon M, Lodge P, Rinkes IHMB, Noji T, Thomson JE, Goh SK, Chapman WC, Cleary SP, Pekolj J, Regimbeau JM, Scatton O, Truant S, Lang H, Fuks D, Bachellier P, Otsuka M, Popescu I, Hasegawa K, Lesurtel M, Adam R, Cherqui D, Uesaka K, Boudjema K, Marques HP, Grąt M, Petrowsky H, Ebata T, Prachalias A, Robles-Campos R, Clavien PA. Novel benchmark values for Open Major Anatomic Liver Resection in non-cirrhotic patients. A multicentric study of 44 International Expert centers. Ann Surg. 2023. https://doi.org/10.1097/SLA.0000000000006012 . Online ahead of print.
doi: 10.1097/SLA.0000000000006012
pubmed: 37497663
Joliat GR, Kobayashi K, Hasegawa K, Thomson JE, Padbury R, Scott M, Brustia R, Scatton O, Tran Cao HS, Vauthey JN, Dincler S, Clavien PA, Wigmore SJ, Demartines N, Melloul E. Guidelines for Perioperative Care for Liver surgery: enhanced recovery after surgery (ERAS) Society recommendations 2022. World J Surg. 2023;47:11–34.
doi: 10.1007/s00268-022-06732-5
pubmed: 36310325
Rahbari NN, Garden OJ, Padbury R, Brooke-Smith M, Crawford M, Adam R, Koch M, Makuuchi M, Dematteo RP, Christophi C, Banting S, Usatoff V, Nagino M, Maddern G, Hugh TJ, Vauthey JN, Greig P, Rees M, Yokoyama Y, Fan ST, Nimura Y, Figueras J, Capussotti L, Büchler MW, Weitz J. Posthepatectomy liver failure: a definition and grading by the International Study Group of Liver surgery (ISGLS). Surgery. 2011;149:713–24.
doi: 10.1016/j.surg.2010.10.001
pubmed: 21236455
Saadat LV, Brajcich BC, Liu Y, Ko C, D’Angelica MI. Defining the risk of liver failure after minor hepatectomy: a NSQIP analysis of 7029 patients. HPB (Oxford). 2021;23:551–9.
doi: 10.1016/j.hpb.2020.08.013
pubmed: 32952033
Sparrelid E, Thorsen T, Sauter C, Jorns C, Stål P, Nordin A, de Boer MT, Buis C, Yaqub S, Schultz NA, Larsen PN, Sallinen V, Line PD, Gilg S. Liver transplantation in patients with posthepatectomy liver failure - A northern European multicenter cohort study. HPB (Oxford). 2022;24:1138–44.
doi: 10.1016/j.hpb.2021.12.005
pubmed: 35067465
Grąt M, Kornasiewicz O, Lewandowski Z, Skalski M, Zieniewicz K, Pączek L, Krawczyk M. The impact of surgical technique on the results of liver transplantation in patients with hepatocellular carcinoma. Ann Transpl. 2013;18:448–59.
doi: 10.12659/AOT.884005
Balzan S, Belghiti J, Farges O, Ogata S, Sauvanet A, Delefosse D, Durand F. The 50–50 criteria on postoperative day 5: an accurate predictor of liver failure and death after hepatectomy. Ann Surg. 2005;242:824–8. discussion 828-9.
doi: 10.1097/01.sla.0000189131.90876.9e
pubmed: 16327492
pmcid: 1409891
Gilg S, Sandström P, Rizell M, Lindell G, Ardnor B, Strömberg C. Isaksson B.The impact of posthepatectomy liver failure on mortality: a population-based study. Scand J Gastroenterol. 2018;53:1335–9.
doi: 10.1080/00365521.2018.1501604
pubmed: 30345846
Baumgartner R, Gilg S, Björnsson B, Hasselgren K, Ghorbani P, Sauter C, Stål P, Sandstöm P, Sparrelid E, Engstrand J. Impact of posthepatectomy liver failure on morbidity and short- and long-term survival after major hepatectomy. BJS Open. 2022;6(4):zrac097.
doi: 10.1093/bjsopen/zrac097
pubmed: 35849062
pmcid: 9291378
Sparrelid E, Olthof PB, Dasari BVM, Erdmann JI, Santol J, Starlinger P, Gilg S. Current evidence on posthepatectomy liver failure: comprehensive review. BJS Open. 2022;6(6):zrac142.
doi: 10.1093/bjsopen/zrac142
pubmed: 36415029
pmcid: 9681670
Angelico R, Siragusa L, Serenari M, Scalera I, Kauffman E, Lai Q, Vitale A. Italian chapter of IHPBA (AICEP, Associazione Italiana Di Chirurgia Epatobilio-Pancreatica). Rescue liver transplantation after posthepatectomy acute liver failure: a systematic review and pooled analysis. Transpl Rev (Orlando). 2023;37:100773.
doi: 10.1016/j.trre.2023.100773
Grąt M, Grzegorczyk K, Lewandowski Z, Sujecki D, Szwedowski D, Boltuc A, Smoter P, Kornasiewicz O, Krawczyk M. Intraoperative injuries during liver resection: analysis of 1,005 procedures. Hepatol Int. 2011;6:498–504.
doi: 10.1007/s12072-011-9281-z
pubmed: 21670969
Kuboki S, Shimizu H, Ohtsuka M, Kato A, Yoshitomi H, Furukawa K, Takayashiki T, Takano S, Okamura D, Suzuki D, Sakai N, Kagawa S, Miyazaki M. Incidence, risk factors, and management options for portal vein thrombosis after hepatectomy: a 14-year, single-center experience. Am J Surg. 2015;210:88 – 85.e2.
Masior Ł, Grąt M. Primary nonfunction and early allograft dysfunction after liver transplantation. Dig Dis. 2022;40:766–76.
doi: 10.1159/000522052
pubmed: 35114676
Masior Ł, Grąt M, Grąt K, Krasnodębski M, Wronka KM, Stypułkowski J, Patkowski W, Frączek M, Krawczyk M, Zieniewicz K. Importance of Intraoperative Transfusions of Packed Red Blood Cells and Fresh Frozen plasma in liver transplantation for Hepatocellular Cancer. Ann Transpl. 2020;25:e923665.
doi: 10.12659/AOT.923665
Thorsen T, Dahlgren US, Aandahl EM, Grzyb K, Karlsen TH, Boberg KM, Rydberg L, Naper C, Foss A, Bennet W. Liver transplantation with deceased ABO-incompatible donors is life-saving but associated with increased risk of rejection and posttransplant complications. Transpl Int. 2015;28:800.
doi: 10.1111/tri.12552
pubmed: 25736519
Pratschke S, Rauch A, Albertsmeier M, Rentsch M, Kirschneck M, Andrassy J, Thomas M, Hartwig W, Figueras J, Del Rio Martin J, De Ruvo N, Werner J, Guba M, Weniger M, Angele MK. Temporary Intraoperative Porto-Caval shunts in Piggy-Back Liver Transplantation reduce intraoperative blood loss and improve postoperative transaminases and renal function: a Meta-analysis. World J Surg. 2016;40:2988–98.
doi: 10.1007/s00268-016-3656-1
pubmed: 27464915
Rayar M, Levi Sandri GB, Cusumano C, Locher C, Houssel-Debry P, Camus C, Lombard N, Desfourneaux V, Lakehal M, Meunier B, Sulpice L, Boudjema K. Benefits of temporary portocaval shunt during orthotopic liver transplantation with vena cava preservation: a propensity score analysis. Liver Transpl. 2017;23:174–83.
doi: 10.1002/lt.24650
pubmed: 27706895
Pinna AD, Yang T, Mazzaferro V, et al. Liver transplantation and hepatic resection can achieve cure for hepatocellular carcinoma. Ann Surg. 2018;268:868–75.
doi: 10.1097/SLA.0000000000002889
pubmed: 30080736
Mazzaferro V, Regalia E, Doci R, Andreola S, Pulvirenti A, Bozzetti F, Montalto F, Ammatuna M, Morabito A, Gennari L. Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis. N Engl J Med. 1996;334:693–9.
doi: 10.1056/NEJM199603143341104
pubmed: 8594428
Mazzaferro V, Sposito C, Zhou J, Pinna AD, De Carlis L, Fan J, Cescon M, Di Sandro S, Yi-Feng H, Lauterio A, Bongini M, Cucchetti A. Metroticket 2.0 model for analysis of competing risks of death after liver transplantation for Hepatocellular Carcinoma. Gastroenterology. 2018;154:128–39.
doi: 10.1053/j.gastro.2017.09.025
pubmed: 28989060
Duvoux C, Roudot-Thoraval F, Decaens T, Pessione F, Badran H, Piardi T, Francoz C, Compagnon P, Vanlemmens C, Dumortier J, Dharancy S, Gugenheim J, Bernard PH, Adam R, Radenne S, Muscari F, Conti F, Hardwigsen J, Pageaux GP, Chazouillères O, Salame E, Hilleret MN, Lebray P, Abergel A, Debette-Gratien M, Kluger MD, Mallat A, Azoulay D, Cherqui D, Liver Transplantation French Study Group. Liver transplantation for Hepatocellular Carcinoma: a model including α-Fetoprotein improves the performance of Milan Criteria. Gastroenterology. 2012;143:986 – 94.e3.
Grąt M, Wronka KM, Stypułkowski J, Bik E, Krasnodębski M, Masior Ł, Lewandowski Z, Grąt K, Patkowski W, Krawczyk M. The Warsaw proposal for the Use of Extended Selection Criteria in Liver Transplantation for Hepatocellular Cancer. Ann Surg Oncol. 2017;24:526–34.
doi: 10.1245/s10434-016-5500-0
pubmed: 27531306
Controversy over Liver Transplantation or Resection for Neuroendocrine Liver Metastasis: Tumor Biology Cuts the Deal, Eshmuminov D, Studer DJ, Lopez Lopez V, Schneider MA, Lerut J, Lo M, Sher L, Musholt TJ, Lozan O, Bouzakri N, Sposito C, Miceli R, Barat S, Morris D, Oehler H, Schreckenbach T, Husen P, Rosen CB, Gores GJ, Masui T, Cheung TT, Kim-Fuchs C, Perren A, Dutkowski P, Petrowsky H, Thiis-Evensen E, Line PD, Grat M, Partelli S, Falconi M, Tanno L, Robles-Campos R, Mazzaferro V, Clavien PA, Lehmann K. Ann Surg. 2022. https://doi.org/10.1097/SLA.0000000000005663 . Online ahead of print.
doi: 10.1097/SLA.0000000000005663
pubmed: 35975918
Heimbach JK, Haddock MG, Alberts SR, Nyberg SL, Ishitani MB, Rosen CB, Gores GJ. Transplantation for hilar cholangiocarcinoma. Liver Transpl. 2004;10(10 Suppl 2):S65–8.
doi: 10.1002/lt.20266
pubmed: 15382214
Breuer E, Mueller M, Doyle MB, Yang L, Darwish Murad S, Anwar IJ, Merani S, Limkemann A, Jeddou H, Kim SC, López-López V, Nassar A, Hoogwater FJH, Vibert E, De Oliveira ML, Cherqui D, Porte RJ, Magliocca JF, Fischer L, Fondevila C, Zieniewicz K, Ramírez P, Foley DP, Boudjema K, Schenk AD, Langnas AN, Knechtle S, Polak WG, Taner CB, Chapman WC, Rosen CB, Gores GJ, Dutkowski P, Heimbach JK, Clavien PA. Liver transplantation as a New Standard of Care in patients with Perihilar Cholangiocarcinoma? Results from an International Benchmark Study. Ann Surg. 2022;276:846–53.
doi: 10.1097/SLA.0000000000005641
pubmed: 35894433
Solheim JM, Dueland S, Line PD, Hagness M. Transplantation for Nonresectable Colorectal Liver metastases - long term follow- up of the first prospective pilot study. Ann Surg. 2023;278:239–45.
doi: 10.1097/SLA.0000000000005703
pubmed: 36082986
Bonney GK, Chew CA, Lodge P, Hubbard J, Halazun KJ, Trunecka P, Muiesan P, Mirza DF, Isaac J, Laing RW, Iyer SG, Chee CE, Yong WP, Muthiah MD, Panaro F, Sanabria J, Grothey A, Moodley K, Chau I, Chan ACY, Wang CC, Menon K, Sapisochin G, Hagness M, Dueland S, Line PD, Adam R. Liver transplantation for nonresectable colorectal liver metastases: the International Hepato-Pancreato-Biliary Association consensus guidelines. Lancet Gastroenterol Hepatol. 2021;6:933–46.
doi: 10.1016/S2468-1253(21)00219-3
pubmed: 34506756
Maspero M, Sposito C, Virdis M, Citterio D, Pietrantonio F, Bhoori S, Belli F, Mazzaferro V. Liver transplantation for hepatic metastases from Colorectal Cancer: current knowledge and open issues. Cancers (Basel). 2023;15:345.
doi: 10.3390/cancers15020345
pubmed: 36672295
De Martin E, Rayar M, Golse N, Dupeux M, Gelli M, Gnemmi V, Allard MA, Cherqui D, Sa Cunha A, Adam R, Coilly A, Antonini TM, Guettier C, Samuel D, Boudjema K, Boleslawski E, Vibert E. Analysis of Liver Resection Versus Liver Transplantation on Outcome of Small Intrahepatic Cholangiocarcinoma and Combined Hepatocellular- Cholangiocarcinoma in the setting of cirrhosis. Liver Transpl. 2020;26(6):785–98. https://doi.org/10.1002/lt.25737 .
doi: 10.1002/lt.25737
pubmed: 32090444
Otsuka Y, Duffy JP, Saab S, Farmer DG, Ghobrial RM, Hiatt JR, Busuttil RW. Postresection hepatic failure: successful treatment with liver transplantation. Liver Transpl. 2007;13:672–9.
doi: 10.1002/lt.20917
pubmed: 17219396
Thorsen T, Solheim JM, Labori KJ, Line PD, Aandahl EM. Liver transplantation as a lifesaving procedure for posthepatectomy liver failure and iatrogenic liver injuries. Langenbecks Arch Surg. 2019;404:301–8.
doi: 10.1007/s00423-019-01780-3
pubmed: 30929063
Müller PC, Linecker M, Kirimker EO, Oberkofler CE, Clavien PA, Balci D, Petrowsky H. Induction of liver hypertrophy for extended liver surgery and partial liver transplantation: state of the art of parenchyma augmentation-assisted liver surgery. Langenbecks Arch Surg. 2021;406:2201–15.
doi: 10.1007/s00423-021-02148-2
pubmed: 33740114
pmcid: 8578101
Olthof PB, Coelen RJS, Bennink RJ, Heger M, Lam MF, Besselink MG, Busch OR, van Lienden KP, van Gulik TM. (99 m)Tc-mebrofenin hepatobiliary scintigraphy predicts liver failure following major liver resection for perihilar cholangiocarcinoma. HPB (Oxford). 2017;19:850–8.
doi: 10.1016/j.hpb.2017.05.007
pubmed: 28687148
Olthof PB, Arntz P, Truant S, El Amrani M, Dasari BVM, Tomassini F, Troisi RI, Bennink RJ, Grunhagen D, Chapelle T, de Op B, Zanoni L, Serenari M, Erdmann JI. Hepatobiliary scintigraphy to predict postoperative liver failure after major liver resection; a multicenter cohort study in 547 patients. HPB (Oxford). 2023;25:417–24.
doi: 10.1016/j.hpb.2022.12.005
pubmed: 36759303
Wang YY, Zhao XH, Ma L, Ye JZ, Wu FX, Tang J, You XM, Xiang BD, Li LQ. Comparison of the ability of child-pugh score, MELD score, and ICG‐R15 to assess preoperative hepatic functional reserve in patients with hepatocellular carcinoma. J Surg Oncol. 2018;118:440–5.
doi: 10.1002/jso.25184
pubmed: 30259515
Díaz Vico T, Granero Castro P, Alcover Navarro L, Suárez Sánchez A, Mihic Góngora L, Montalvá Orón EM, Maupoey Ibáñez J. Truán Alonso N, González-Pinto Arrillaga I, Granero Trancón JE. Two stage hepatectomy (TSH) versus ALPPS for initially unresectable colorectal liver metastases: a systematic review and meta-analysis. Eur J Surg Oncol. 2023;49:550–9.
doi: 10.1016/j.ejso.2022.11.010
pubmed: 36424260
Akbulut S, Cicek E, Kolu M, Sahin TT, Yilmaz S. Associating liver section and portal vein ligation for staged hepatectomy for extensive alveolar echinococcosis: first case report in the literature. World J Gastrointest Surg. 2018;10:1–5.
doi: 10.4240/wjgs.v10.i1.1
pubmed: 29391928
pmcid: 5785687
Life-threatening or nearly life-threatening complications in living liver donors. Clin Transpl. 2018;32(6):e13262.
Xu L, Lin W, Wen L, Li G. Lgr5 in cancer biology: functional identification of Lgr5 in cancer progression and potential opportunities for novel therapy. Stem Cell Res Ther. 2019;10:219.
doi: 10.1186/s13287-019-1288-8
pubmed: 31358061
pmcid: 6664754
Gong X, Azhdarinia A, Ghosh SC, Xiong W, An Z, Liu Q, Carmon KS. LGR5-Targeted antibody–drug Conjugate eradicates gastrointestinal tumors and prevents recurrence. Mol Cancer Ther. 2016;15:1580–90.
doi: 10.1158/1535-7163.MCT-16-0114
pubmed: 27207778