Human genetic structure in Northwest France provides new insights into West European historical demography.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
07 Aug 2024
07 Aug 2024
Historique:
received:
21
06
2023
accepted:
29
07
2024
medline:
8
8
2024
pubmed:
8
8
2024
entrez:
7
8
2024
Statut:
epublish
Résumé
The demographical history of France remains largely understudied despite its central role toward understanding modern population structure across Western Europe. Here, by exploring publicly available Europe-wide genotype datasets together with the genomes of 3234 present-day and six newly sequenced medieval individuals from Northern France, we found extensive fine-scale population structure across Brittany and the downstream Loire basin and increased population differentiation between the northern and southern sides of the river Loire, associated with higher proportions of steppe vs. Neolithic-related ancestry. We also found increased allele sharing between individuals from Western Brittany and those associated with the Bell Beaker complex. Our results emphasise the need for investigating local populations to better understand the distribution of rare (putatively deleterious) variants across space and the importance of common genetic legacy in understanding the sharing of disease-related alleles between Brittany and people from western Britain and Ireland.
Identifiants
pubmed: 39112481
doi: 10.1038/s41467-024-51087-1
pii: 10.1038/s41467-024-51087-1
doi:
Types de publication
Journal Article
Historical Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
6710Subventions
Organisme : Agence Nationale de la Recherche (French National Research Agency)
ID : ANR-16-599-CE12-0033
Organisme : Agence Nationale de la Recherche (French National Research Agency)
ID : ANR-08-BLAN-0028
Organisme : Agence Nationale de la Recherche (French National Research Agency)
ID : ANR-10-LABX-0013
Organisme : Agence Nationale de la Recherche (French National Research Agency)
ID : ANR-10-LABX-0013
Organisme : Agence Nationale de la Recherche (French National Research Agency)
ID : ANR-14-CE10-0001
Informations de copyright
© 2024. The Author(s).
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