Brain natriuretic peptide as a predictive marker of mortality in sepsis: an updated systematic review and meta-analysis.
Brain natriuretic peptide (BNP)
Meta-analysis
Mortality
N-terminal pro-B-type natriuretic peptide
Sepsis
Journal
BMC anesthesiology
ISSN: 1471-2253
Titre abrégé: BMC Anesthesiol
Pays: England
ID NLM: 100968535
Informations de publication
Date de publication:
07 Aug 2024
07 Aug 2024
Historique:
received:
22
06
2024
accepted:
29
07
2024
medline:
8
8
2024
pubmed:
8
8
2024
entrez:
7
8
2024
Statut:
epublish
Résumé
Early identification of patients with sepsis at high risk of death remains a challenge, and whether brain natriuretic peptide (BNP) or N-terminal pro-B-type natriuretic peptide (NT-proBNP) has a prognostic effect on patients with sepsis is controversial. Here, we clarified the prognostic value of BNP and NT-proBNP and sought to establish suitable cutoff values and intervals. We searched five databases to identify studies that met the inclusion criteria. The primary outcomes were the pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), area under the curve (AUC), and corresponding 95% credible interval (95% CI) of BNP and NT-proBNP. The secondary outcomes were the sensitivity and specificity of BNP or NT-proBNP in subgroup analyses. Forty-seven studies were included in our meta-analysis. The pooled sensitivity of NT-proBNP (0.77 [0.68, 0.84]) was weaker than that of BNP (0.82 [0.76, 0.87]), the pooled specificity of NT-proBNP (0.70 [0.60, 0.77]) was less than that of BNP (0.77 [0.71, 0.82]), and the AUC of BNP (0.87 [0.83-0.89]) was greater than that of NT-proBNP (0.80 (0.76-0.83]). The results of the subgroup analysis showed that the cutoff range of 400-800 pg/mL for BNP had high sensitivity (0.86 [0.74-0.98]) and specificity (0.87 [0.81-0.93]) and was probably the most appropriate cutoff range. Elevated levels of BNP and NT-proBNP were significantly related to the mortality of patients with sepsis and had a moderate prognostic value in predicting the mortality of patients with sepsis. In addition, our meta-analysis preliminarily established appropriate cutoff values for BNP and NT-proBNP.
Identifiants
pubmed: 39112946
doi: 10.1186/s12871-024-02661-z
pii: 10.1186/s12871-024-02661-z
doi:
Substances chimiques
Natriuretic Peptide, Brain
114471-18-0
Biomarkers
0
Peptide Fragments
0
pro-brain natriuretic peptide (1-76)
0
Types de publication
Journal Article
Meta-Analysis
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
276Subventions
Organisme : Sichuan Key Clinical Specialty project
ID : 2022-16
Organisme : Sichuan Key Clinical Specialty project
ID : 2022-16
Organisme : Sichuan Key Clinical Specialty project
ID : 2022-16
Organisme : Sichuan Key Clinical Specialty project
ID : 2022-16
Organisme : Sichuan Key Clinical Specialty project
ID : 2022-16
Organisme : Sichuan Key Clinical Specialty project
ID : 2022-16
Informations de copyright
© 2024. The Author(s).
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