Regulation of Zfp36 by ISGF3 and MK2 restricts the expression of inflammatory cytokines during necroptosis stimulation.
Tristetraprolin
/ metabolism
Necroptosis
Animals
Cytokines
/ metabolism
Mice
Protein Serine-Threonine Kinases
/ metabolism
Intracellular Signaling Peptides and Proteins
/ metabolism
Receptor-Interacting Protein Serine-Threonine Kinases
/ metabolism
Macrophages
/ metabolism
Humans
Inflammation
/ metabolism
RAW 264.7 Cells
Up-Regulation
/ drug effects
Interferon-beta
/ metabolism
Mice, Inbred C57BL
Gene Expression Regulation
Journal
Cell death & disease
ISSN: 2041-4889
Titre abrégé: Cell Death Dis
Pays: England
ID NLM: 101524092
Informations de publication
Date de publication:
08 Aug 2024
08 Aug 2024
Historique:
received:
22
01
2024
accepted:
31
07
2024
revised:
29
07
2024
medline:
9
8
2024
pubmed:
9
8
2024
entrez:
8
8
2024
Statut:
epublish
Résumé
Necrosome activation following TLR- or cytokine receptor-signaling results in cell death by necroptosis which is characterized by the rupture of cell membranes and the consequent release of intracellular contents to the extracellular milieu. While necroptosis exacerbates various inflammatory diseases, the mechanisms through which the inflammatory responses are regulated are not clear. We show that the necrosome activation of macrophages results in an upregulation of various pathways, including the mitogen-activated protein kinase (MAPK) cascade, which results in an elevation of the inflammatory response and consequent expression of several cytokines and chemokines. Programming for this upregulation of inflammatory response occurs during the early phase of necrosome activation and proceeds independently of cell death but depends on the activation of the receptor-interacting protein kinase-1 (RipK1). Interestingly, necrosome activation also results in an upregulation of IFNβ, which in turn exerts an inhibitory effect on the maintenance of inflammatory response through the repression of MAPK-signaling and an upregulation of Zfp36. Activation of the interferon-induced gene factor-3 (ISGF3) results in the expression of ZFP36 (TTP), which induces the post-transcriptional degradation of mRNAs of various inflammatory cytokines and chemokines through the recognition of AU-rich elements in their 3'UTR. Furthermore, ZFP-36 inhibits IFNβ-, but not TNFα- induced necroptosis. Overall, these results reveal the molecular mechanism through which IFNβ, a pro-inflammatory cytokine, induces the expression of ZFP-36, which in turn inhibits necroptosis and halts the maintenance of the inflammatory response.
Identifiants
pubmed: 39117638
doi: 10.1038/s41419-024-06964-4
pii: 10.1038/s41419-024-06964-4
doi:
Substances chimiques
Tristetraprolin
0
MAP-kinase-activated kinase 2
EC 2.7.1.-
Cytokines
0
Protein Serine-Threonine Kinases
EC 2.7.11.1
Intracellular Signaling Peptides and Proteins
0
Receptor-Interacting Protein Serine-Threonine Kinases
EC 2.7.11.1
Zfp36 protein, mouse
0
Interferon-beta
77238-31-4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
574Subventions
Organisme : Gouvernement du Canada | Canadian Institutes of Health Research (Instituts de Recherche en Santé du Canada)
ID : PJT-165934
Informations de copyright
© 2024. The Author(s).
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