An unusual two-strain cholera outbreak in Lebanon, 2022-2023: a genomic epidemiology study.

Lebanon / epidemiology Humans Cholera / epidemiology Disease Outbreaks Phylogeny Genome, Bacterial / genetics Genomics / methods Vibrio cholerae / genetics Male Anti-Bacterial Agents / pharmacology Female Vibrio cholerae O1 / genetics Adolescent Adult Young Adult Middle Aged Child Molecular Epidemiology

Journal

Nature communications

ISSN: 2041-1723

Titre abrégé: Nat Commun

Pays: England

ID NLM: 101528555

Informations de publication

Date de publication:
13 Aug 2024

Historique:

received: 25 01 2024

accepted: 07 08 2024

medline: 14 8 2024

pubmed: 14 8 2024

entrez: 13 8 2024

Statut: epublish

Résumé

Cholera is a life-threatening gastrointestinal infection caused by a toxigenic bacterium, Vibrio cholerae. After a lull of almost 30 years, a first case of cholera was detected in Lebanon in October 2022. The outbreak lasted three months, with 8007 suspected cases (671 laboratory-confirmed) and 23 deaths. In this study, we use phenotypic methods and microbial genomics to study 34 clinical and environmental Vibrio cholerae isolates collected throughout this outbreak. All isolates are identified as V. cholerae O1, serotype Ogawa strains from wave 3 of the seventh pandemic El Tor (7PET) lineage. Phylogenomic analysis unexpectedly reveals the presence of two different strains of the seventh pandemic El Tor (7PET) lineage. The dominant strain has a narrow antibiotic resistance profile and is phylogenetically related to South Asian V. cholerae isolates and derived African isolates from the AFR15 sublineage. The second strain is geographically restricted and extensively drug-resistant. It belongs to the AFR13 sublineage and clusters with V. cholerae isolates collected in Yemen. In conclusion, the 2022-2023 Lebanese cholera outbreak is caused by the simultaneous introduction of two different 7PET strains. Genomic surveillance with cross-border collaboration is therefore crucial for the identification of new introductions and routes of circulation of cholera, improving our understanding of cholera epidemiology.

Identifiants

DOI: 10.1038/s41467-024-51428-0 PMID: 39138238

pubmed: 39138238

doi: 10.1038/s41467-024-51428-0

pii: 10.1038/s41467-024-51428-0

doi:

Substances chimiques

Anti-Bacterial Agents 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

Pagination

6963

Subventions

Organisme : U.S. Department of Health & Human Services | Centers for Disease Control and Prevention (CDC)

ID : 75D301-21-C-12132

Informations de copyright

Références

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