Infant Botulism: In Search of Clostridium botulinum Spores.
Journal
Current microbiology
ISSN: 1432-0991
Titre abrégé: Curr Microbiol
Pays: United States
ID NLM: 7808448
Informations de publication
Date de publication:
13 Aug 2024
13 Aug 2024
Historique:
received:
24
05
2024
accepted:
31
07
2024
medline:
14
8
2024
pubmed:
14
8
2024
entrez:
14
8
2024
Statut:
epublish
Résumé
Infant botulism is now the most common form of human botulism in Canada and the United States. Infant botulism is a severe neuroparalytic disease caused by ingestion of the spore-forming neurotoxic clostridia, including Clostridium botulinum that colonize the large intestine and subsequently produce botulinum neurotoxin in situ. It has been over a century since the first surveys documenting the ubiquitous prevalence of C. botulinum in soils around the world. Since then, honey has been identified as the only well-known risk factor for infant botulism despite a multitude of international environmental surveys isolating C. botulinum spores from ground soil, aquatic sediments, and commonly available infant foods. Associations of infant botulism cases with confirmed sources of C. botulinum exposure have primarily implicated outdoor soil and indoor dust, as well as commonly ingested foods including honey, dry cereals, and even powdered infant formula. Yet the origin of infection remains unknown for most infant botulism cases. This review summarizes the various surveys from around the world for C. botulinum in environmental soils and sediments, honey, and other infant foods, as well as laboratory-confirmed associations with documented infant botulism cases. Additional factors are also discussed, including the composition of infant gut microbiota and the practice of breastfeeding. We make several recommendations to better identify sources of exposure to C. botulinum spores that could lead to effective preventive measures and help reduce the incidence of this rare but life-threatening disease.
Identifiants
pubmed: 39138824
doi: 10.1007/s00284-024-03828-0
pii: 10.1007/s00284-024-03828-0
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
306Informations de copyright
© 2024. Crown.
Références
Smith T, Williamson CHD, Hill K, Sahl J, Keim P (2018) Botulinum neurotoxin-producing bacteria. Isn’t it time that we called a species a species? mBio. 9:1469
doi: 10.1128/mBio.01469-18
Hauschild A (1989) Clostridium botulinum. Foodborne Bacterial Pathogens. New York, Marcel Dekker Inc, Doyle M, p 111
Meurens F, Carlin F, Federighi M, Filippitzi M, Fournier M, Fravalo P, Ganière J, Grisot L, Guillier L, Hilaire D et al (2022) Clostridium botulinum type C, D, C/D, and D/C: an update. Front Microbiol 13:1099184. https://doi.org/10.3389/fmicb.2022.1099184
doi: 10.3389/fmicb.2022.1099184
Sonnabend O, Sonnabend W, Heinzle R, Sigrist T, Dirnhofer R, Krech U (1981) Isolation of Clostridium botulinum type G and identification of type G botulinal toxin in humans: report of five sudden unexpected deaths. J Infect Dis 143:22–27. https://doi.org/10.1093/infdis/143.1.22
doi: 10.1093/infdis/143.1.22
Harris R, Tchao C, Prystajecky N, Cutler J, Austin JW (2021) A summary of surveillance, morbidity and microbiology of laboratory-confirmed cases of infant botulism in Canada, 1979–2019. Can Commun Dis Rep 47:322–328. https://doi.org/10.14745/ccdr.v47i78a05
doi: 10.14745/ccdr.v47i78a05
National Botulism Surveillance Summary, 2018 | Botulism | CDC. (2022) https://www.cdc.gov/botulism/php/national-botulism-surveillance/2018.html . Accessed Apr 3,2023.
Koepke R, Sobel J, Arnon SS (2008) Global occurrence of infant botulism, 1976–2006. Pediatrics 122:73. https://doi.org/10.1542/peds.2007-1827
doi: 10.1542/peds.2007-1827
Koenig JE, Spor A, Scalfone N, Fricker AD, Stombaugh J, Knight R, Angenent LT, Ley RE (2011) Succession of microbial consortia in the developing infant gut microbiome. Proc Natl Acad Sci U S A 108:4578–4585. https://doi.org/10.1073/pnas.1000081107
doi: 10.1073/pnas.1000081107
Thilo EH, Townsend SF, Deacon J (1993) Infant botulism at 1 week of age: report of two cases. Pediatrics 92:151–153. https://doi.org/10.1542/peds.92.1.151
doi: 10.1542/peds.92.1.151
Barash JR, Tang TWH, Arnon SS (2005) First case of infant botulism caused by Clostridium baratii type F in California. J Clin Microbiol 43:4280–4282. https://doi.org/10.1128/JCM.43.8.4280-4282.2005
doi: 10.1128/JCM.43.8.4280-4282.2005
Lúquez C, Dykes JK, Yu PA, Raphael BH, Maslanka SE (2010) First report worldwide of an infant botulism case due to Clostridium botulinum type E. J Clin Microbiol 48:326–328. https://doi.org/10.1128/JCM.01420-09
doi: 10.1128/JCM.01420-09
Abe Y, Negasawa T, Monma C, Oka A (2008) Infantile botulism caused by Clostridium butyricum type E toxin. Pediatr Neurol 38:55–57. https://doi.org/10.1016/j.pediatrneurol.2007.08.013
doi: 10.1016/j.pediatrneurol.2007.08.013
Dykes JK, Lúquez C, Raphael BH, McCroskey L, Maslanka SE (2015) Laboratory investigation of the first case of botulism caused by Clostridium butyricum type E toxin in the United States. J Clin Microbiol 53:3363–3365. https://doi.org/10.1128/JCM.01351-15
doi: 10.1128/JCM.01351-15
Fenicia L, Da Dalt L, Anniballi F, Franciosa G, Zanconato S, Aureli P (2002) A case of infant botulism due to neurotoxigenic Clostridium butyricum type E associated with Clostridium difficile colitis. Eur J Clin Microbiol Infect Dis 21:736–738. https://doi.org/10.1007/s10096-002-0816-z
doi: 10.1007/s10096-002-0816-z
McCroskey LM, Hatheway CL, Fenicia L, Pasolini B, Aureli P (1986) Characterization of an organism that produces type E botulinal toxin but which resembles Clostridium butyricum from the feces of an infant with type E botulism. J Clin Microbiol 23:201–202. https://doi.org/10.1128/jcm.23.1.201-202.1986
doi: 10.1128/jcm.23.1.201-202.1986
Aureli P, Fenicia L, Pasolini B, Gianfranceschi M, McCroskey LM, Hatheway CL (1986) Two cases of type E infant botulism caused by neurotoxigenic Clostridium butyricum in Italy. J Infect Dis 154:207–211. https://doi.org/10.1093/infdis/154.2.207
doi: 10.1093/infdis/154.2.207
Paisley JW, Lauer BA, Arnon SS (1995) A second case of infant botulism type F caused by Clostridium baratii. Pediatr Infect Dis J 14:912–914
doi: 10.1097/00006454-199510000-00022
Halpin AL, Khouri JM, Payne JR, Nakao JH, Cronquist A, Kalas N, Mohr M, Osborne M, O’Dell S, Luquez C et al (2017) Type F infant botulism: investigation of recent clusters and overview of this exceedingly rare disease. Clin Infect Dis 66:S92–S94. https://doi.org/10.1093/cid/cix818
doi: 10.1093/cid/cix818
Moodley A, Quinlisk P, Garvey A, Kalas N, Barash JR, Khouri JM (2015) Infant botulism caused by Clostridium baratii type F — Iowa, 2013. MMWR Morb Mortal Wkly Rep 64:400
Oguma K, Yokota K, Hayashi S, Takeshi K, Kumagai M, Itoh N, Tachi N, Chiba S (1990) Infant botulism due to Clostridium botulinum type C toxin. Lancet 336:1449–1450. https://doi.org/10.1016/0140-6736(90)93157-k
doi: 10.1016/0140-6736(90)93157-k
Meyer KF, Dubovsky BJ (1922) The distribution of the spores of B. botulinus in the United States. IV J Infect Dis 31:559–594. https://doi.org/10.1093/infdis/31.6.559
doi: 10.1093/infdis/31.6.559
Meyer KF, Dubovsky BJ (1922) The distribution of the spores of B. botulinus in California. II J Infect Dis 31:541–555. https://doi.org/10.1093/infdis/31.6.541
doi: 10.1093/infdis/31.6.541
Meyer KF, Dubovsky BJ (1922) The occurrence of the spores of B. botulinus in Belgium, Denmark, England, The Netherlands and Switzerland. VI J Infect Dis 31:600–609. https://doi.org/10.1093/infdis/31.6.600
doi: 10.1093/infdis/31.6.600
Schoenholz P, Meyer KF (1922) The occurrence of the spores of B. botulinus in the Hawaiian Islands and China. VII J Infect Dis 31:610–613. https://doi.org/10.1093/infdis/31.6.610
doi: 10.1093/infdis/31.6.610
Dubovsky BJ, Meyer KF (1922) The distribution of the spores of B. botulinus in the territory of Alaska and the dominion of Canada. V J Infect Dis 31:595–599
doi: 10.1093/infdis/31.6.595
Brett MM, McLauchlin J, Harris A, O’Brien S, Black N, Forsyth RJ, Roberts D, Bolton FJ (2005) A case of infant botulism with a possible link to infant formula milk powder: evidence for the presence of more than one strain of Clostridium botulinum in clinical specimens and food. J Med Microbiol 54:769–776. https://doi.org/10.1099/jmm.0.46000-0
doi: 10.1099/jmm.0.46000-0
Johnson EA, Tepp WH, Bradshaw M, Gilbert RJ, Cook PE, McIntosh EDG (2005) Characterization of Clostridium botulinum strains associated with an infant botulism case in the United Kingdom. J Clin Microbiol 43:2602–2607. https://doi.org/10.1128/JCM.43.6.2602-2607.2005
doi: 10.1128/JCM.43.6.2602-2607.2005
Spika JS, Shaffer N, Hargrett-Bean N, Collin S, MacDonald KL, Blake PA (1989) Risk factors for infant botulism in the United States. Am J Dis Child 143:828–832. https://doi.org/10.1001/archpedi.1989.02150190078026
doi: 10.1001/archpedi.1989.02150190078026
Dabritz HA, Hill KK, Barash JR, Ticknor LO, Helma CH, Dover N, Payne JR, Arnon SS (2014) Molecular epidemiology of infant botulism in California and elsewhere, 1976–2010. J Infect Dis 210:1711–1722. https://doi.org/10.1093/infdis/jiu331
doi: 10.1093/infdis/jiu331
Panditrao MV, Dabritz HA, Kazerouni NN, Damus KH, Meissinger JK, Arnon SS (2020) Seven-year case-control study in California of risk factors for infant botulism. J Pediatr 227:258-267.e8. https://doi.org/10.1016/j.jpeds.2020.07.014
doi: 10.1016/j.jpeds.2020.07.014
Midura TF, Arnon SS (1976) Infant botulism. Identification of Clostridium botulinum and its toxins in faeces. Lancet 2:934–936. https://doi.org/10.1016/s0140-6736(76)90894-1
doi: 10.1016/s0140-6736(76)90894-1
Sugiyama H, Mills DC, Kuo L-C (1978) Number of Clostridium botulinum spores in honey. J Food Prot 41:848–850. https://doi.org/10.4315/0362-028X-41.11.848
doi: 10.4315/0362-028X-41.11.848
Midura TF (1979) Laboratory aspects of infant botulism in California. Rev Infect Dis 1:652–655. https://doi.org/10.1093/clinids/1.4.652
doi: 10.1093/clinids/1.4.652
Chin J, Arnon SS, Midura TF (1979) Food and environmental aspects of infant botulism in California. Rev Infect Dis 1:693–697. https://doi.org/10.1093/clinids/1.4.693
doi: 10.1093/clinids/1.4.693
Arnon SS, Midura TF, Damus K, Thompson B, Wood RM, Chin J (1979) Honey and other environmental risk factors for infant botulism. J Pediatr 94:331–336. https://doi.org/10.1016/s0022-3476(79)80863-x
doi: 10.1016/s0022-3476(79)80863-x
Arnon SS, Damus K, Chin J (1981) Infant botulism: epidemiology and relation to sudden infant death syndrome. Epidemiol Rev 3:45–66. https://doi.org/10.1093/oxfordjournals.epirev.a036239
doi: 10.1093/oxfordjournals.epirev.a036239
American Academy of Pediatrics Policy statement: honey and infant botulism. (1981) Pediatrics 32:5.
Panditrao MV, Dabritz HA, Kazerouni NN, Damus KH, Meissinger JK, Arnon SS (2020) Descriptive epidemiology of infant botulism in California: The first 40 years. J Pediatr 227:247-257.e3. https://doi.org/10.1016/j.jpeds.2020.08.013
doi: 10.1016/j.jpeds.2020.08.013
Hubtanen CN, Knox D, Sbimanuki H (1981) Incidence and origin of Clostridium botulinum spores in honey. J Food Prot 44:812–814. https://doi.org/10.4315/0362-028X-44.11.812
doi: 10.4315/0362-028X-44.11.812
Hauschild A, Dodds K (1993) Clostridium botulinum: Ecology and control in foods. CRC Press, Boca Raton
Nevas M, Lindström M, Hautamäki K, Puoskari S, Korkeala H (2005) Prevalence and diversity of Clostridium botulinum types A, B, E and F in honey produced in the Nordic countries. Int J Food Microbiol 105:145–151. https://doi.org/10.1016/j.ijfoodmicro.2005.04.007
doi: 10.1016/j.ijfoodmicro.2005.04.007
Tølløfsrud PA, Kvittingen EA, Granum PE, Vøllo A (1998) Botulism in newborn infants. Tidsskr Nor Laegeforen 118:4355–4356
Nevas M, Hielm S, Lindström M, Horn H, Koivulehto K, Korkeala H (2002) High prevalence of Clostridium botulinum types A and B in honey samples detected by polymerase chain reaction. Int J Food Microbiol 72:45–52. https://doi.org/10.1016/s0168-1605(01)00615-8
doi: 10.1016/s0168-1605(01)00615-8
Kautter DA, Lilly T, Solomon HM, Lynt RK (1982) Clostridium botulinum spores in infant foods: A survey. J Food Prot 45:1028–1029. https://doi.org/10.4315/0362-028X-45.11.1028
doi: 10.4315/0362-028X-45.11.1028
Lilly T, Rhodehamel EJ, Kautter DA, Solomon HM (1991) Clostridium botulinum spores in corn syrup and other syrups. J Food Prot 54:585–587. https://doi.org/10.4315/0362-028X-54.8.585
doi: 10.4315/0362-028X-54.8.585
Waler JA (2000) Risk of infant botulism from corn syrup. Pediatr Infect Dis J 19:584
doi: 10.1097/00006454-200006000-00025
Nakano H, Yoshikuni Y, Hashimoto H, Sakaguchi G (1992) Detection of Clostridium botulinum in natural sweetening. Int J Food Microbiol 16:117–121. https://doi.org/10.1016/0168-1605(92)90004-m
doi: 10.1016/0168-1605(92)90004-m
Bianco MI, Lúquez C, de Jong LIT, Fernández RA (2008) Presence of Clostridium botulinum spores in Matricaria chamomilla (chamomile) and its relationship with infant botulism. Int J Food Microbiol 121:357–360. https://doi.org/10.1016/j.ijfoodmicro.2007.11.008
doi: 10.1016/j.ijfoodmicro.2007.11.008
Bianco MI, Lúquez C, de Jong LIT, Fernández RA (2009) Linden flower (Tilia spp.) as potential vehicle of Clostridium botulinum spores in the transmission of infant botulism. Rev Argent Microbiol 41:232–236
Hauschild AHW, Hilsheimer R, Weiss KF, Burke RB (1988) Clostridium botulinum in honey, syrups and dry infant cereals. J Food Prot 51:892–894. https://doi.org/10.4315/0362-028X-51.11.892
doi: 10.4315/0362-028X-51.11.892
Report on minimally processed infant weaning foods and the risk of infant botulism. (2006) Food Standards Agency. https://acmsf.food.gov.uk/sites/default/files/mnt/drupal_data/sources/files/multimedia/pdfs/infantbotulismreport.pdf . Accessed September 25,2023.
The Codex Alimentarius Commission (2008) RCP 66 - Code of Hygienic practice for powdered formulae for infants and young children. Food and Agriculture Organization of the United Nations. https://www.fao.org/input/download/standards/11026/CXP_066e.pdf . Accessed September 25, 2023.
Usefulness of testing for Clostridium botulinum in powdered infant formula and dairy-based ingredients for infant formula. (2014) International Commission on Microbiological Specifications for Foods. International Union of Microbiological Societies. https://www.icmsf.org/wp-content/uploads/2018/02/ICMSF_Infant_Formula_Testing_Revision1-20140117.pdf . Accessed September 25, 2023.
Barash JR, Hsia JK, Arnon SS (2010) Presence of soil-dwelling clostridia in commercial powdered infant formulas. J Pediatr 156:402–408. https://doi.org/10.1016/j.jpeds.2009.09.072
doi: 10.1016/j.jpeds.2009.09.072
Dong YP, Wang W, Jiang T, Xu J, Han CH, Yan SF, Fanning S, Li Y, Ma XC, Zhang D et al (2017) Molecular and epidemiological characterization of infant botulism in Beijing, China. Biomed Environ Sci 30:460–464. https://doi.org/10.3967/bes2017.061
doi: 10.3967/bes2017.061
Hauschild AHW, Aris BJ, Hilsheimer R (1975) Clostridium botulinum in marinated products. Can Inst Food Sci Technol J 8:84–87. https://doi.org/10.1016/S0315-5463(75)73727-6
doi: 10.1016/S0315-5463(75)73727-6
Lilly T, Solomon HM, Rhodehamel EJ (1996) Incidence of Clostridium botulinum in vegetables packaged under vacuum or modified atmosphere. J Food Prot 59:59–61. https://doi.org/10.4315/0362-028X-59.1.59
doi: 10.4315/0362-028X-59.1.59
Braconnier A, Broussolle V, Perelle S, Fach P, Nguyen-The C, Carlin F (2001) Screening for Clostridium botulinum type A, B, and E in cooked chilled foods containing vegetables and raw material using polymerase chain reaction and molecular probes. J Food Prot 64:201–207. https://doi.org/10.4315/0362-028x-64.2.201
doi: 10.4315/0362-028x-64.2.201
Sevenier V, Delannoy S, André S, Fach P, Remize F (2012) Prevalence of Clostridium botulinum and thermophilic heat-resistant spores in raw carrots and green beans used in French canning industry. Int J Food Microbiol 155:263–268. https://doi.org/10.1016/j.ijfoodmicro.2012.02.009
doi: 10.1016/j.ijfoodmicro.2012.02.009
Pernu N, Keto-Timonen R, Lindström M, Korkeala H (2020) High prevalence of Clostridium botulinum in vegetarian sausages. Food Microbiol 91:103512. https://doi.org/10.1016/j.fm.2020.103512
doi: 10.1016/j.fm.2020.103512
Burke GS (1919) The occurrence of Bacillus botulinus in nature. J Bacteriol 4:541–553
doi: 10.1128/jb.4.5.541-553.1919
Hielm S, Hyytiä E, Andersin AB, Korkeala H (1998) A high prevalence of Clostridium botulinum type E in finnish freshwater and Baltic sea sediment samples. J Appl Microbiol 84:133–137. https://doi.org/10.1046/j.1365-2672.1997.00331.x
doi: 10.1046/j.1365-2672.1997.00331.x
Harris RA, Blondin-Brosseau M, Levesque C, Rasmussen PE, Beauchemin S, Austin JW (2023) Viable Clostridium botulinum spores not detected in the household dust of major Canadian cities. Epidemiol Infect. https://doi.org/10.1017/S0950268823001474
doi: 10.1017/S0950268823001474
Long SS, Gajewski JL, Brown LW, Gilligan PH (1985) Clinical, laboratory, and environmental features of infant botulism in Southeastern Pennsylvania. Pediatrics 75:935–941
doi: 10.1542/peds.75.5.935
Smith LD (1978) The occurrence of Clostridium botulinum and Clostridium tetani in the soil of the United States. Health Lab Sci 15:74–80
Leclair D, Farber JM, Doidge B, Blanchfield B, Suppa S, Pagotto F, Austin JW (2013) Distribution of Clostridium botulinum type E strains in nunavik, Northern Quebec, Canada. Appl Environ Microbiol 79:646–654. https://doi.org/10.1128/AEM.05999-11
doi: 10.1128/AEM.05999-11
Parry EW (1946) Prevalence of Clostridium botulinum in soils of central New York state. Food Res 11:203–209. https://doi.org/10.1111/j.1365-2621.1946.tb16345.x
doi: 10.1111/j.1365-2621.1946.tb16345.x
Huss HH (1980) Distribution of Clostridium botulinum. Appl Environ Microbiol 39:764–769
doi: 10.1128/aem.39.4.764-769.1980
Lúquez C, Bianco MI, de Jong LIT, Sagua MD, Arenas GN, Ciccarelli AS, Fernández RA (2005) Distribution of botulinum toxin-producing clostridia in soils of Argentina. Appl Environ Microbiol 71:4137–4139. https://doi.org/10.1128/AEM.71.7.4137-4139.2005
doi: 10.1128/AEM.71.7.4137-4139.2005
Xin W, Huang Y, Ji B, Li P, Wu Y, Liu J, Wang X, Yang H, Kang L, Gao S et al (2019) Identification and characterization of clostridium botulinum strains associated with an infant botulism case in China. Anaerobe 55:1–7. https://doi.org/10.1016/j.anaerobe.2018.06.015
doi: 10.1016/j.anaerobe.2018.06.015
Saraiva M, Campos Cunha I, Costa Bonito C, Pena C, Toscano MM, Teixeira Lopes T, Sousa I, Calhau MA (2012) First case of infant botulism in Portugal. Food Control 26:79–80. https://doi.org/10.1016/j.foodcont.2012.01.010
doi: 10.1016/j.foodcont.2012.01.010
Kobayashi T, Haginoya K, Morimoto T, Hatakeyama T, Tsuchiya S (2014) A case of infant botulism infection due to consumption of untreated well-water. J Pediatr 164:931–933. https://doi.org/10.1016/j.jpeds.2013.11.044
doi: 10.1016/j.jpeds.2013.11.044
Shelley EB, O’Rourke D, Grant K, McArdle E, Capra L, Clarke A, McNamara E, Cunney R, McKeown P, Amar CF et al (2015) Infant botulism due to C. butyricum type E toxin: a novel environmental association with pet terrapins. Epidemiol Infect 143:461–469. https://doi.org/10.1017/S0950268814002672
doi: 10.1017/S0950268814002672
Goldberg B, Danino D, Levinsky Y, Levy I, Straussberg R, Dabaja-Younis H, Guri A, Almagor Y, Tasher D, Elad D et al (2023) Infant botulism, Israel, 2007–2021. Emerg Infect Dis 29:235–241. https://doi.org/10.3201/eid2902.220991
doi: 10.3201/eid2902.220991
Stark PL, Lee A (1982) The microbial ecology of the large bowel of breastfed and formula-fed infants during the first year of life. J Med Microbiol 15:189–203. https://doi.org/10.1099/00222615-15-2-189
doi: 10.1099/00222615-15-2-189
Palmer C, Bik EM, DiGiulio DB, Relman DA, Brown PO (2007) Development of the human infant intestinal microbiota. PLoS Biol 5:e177. https://doi.org/10.1371/journal.pbio.0050177
doi: 10.1371/journal.pbio.0050177
Rodríguez M, Stanton R, Kober J, Avershina R, Narbad J et al (2015) The composition of the gut microbiota throughout life, with an emphasis on early life. Microb Ecol Health Dis. https://doi.org/10.3402/mehd.v26.26050
doi: 10.3402/mehd.v26.26050
Derrien M, Alvarez A, de Vos WM (2019) The gut microbiota in the first decade of life. Trends Microbiol 27:997–1010. https://doi.org/10.1016/j.tim.2019.08.001
doi: 10.1016/j.tim.2019.08.001
Moberg LJ, Sugiyama H (1979) Microbial ecological basis of infant botulism as studied with germfree mice. Infect Immun 25:653–657
doi: 10.1128/iai.25.2.653-657.1979
Wells CL, Sugiyama H, Bland SE (1982) Resistance of mice with limited intestinal flora to enteric colonization by Clostridium botulinum. J Infect Dis 146:791–796. https://doi.org/10.1093/infdis/146.6.791
doi: 10.1093/infdis/146.6.791
Burr DH, Sugiyama H (1982) Susceptibility to enteric botulinum colonization of antibiotic-treated adult mice. Infect Immun 36:103–106
doi: 10.1128/iai.36.1.103-106.1982
Thompson JA, Glasgow LA, Warpinski JR, Olson C (1980) Infant botulism: clinical spectrum and epidemiology. Pediatrics 66:936–942
doi: 10.1542/peds.66.6.936
Shirey TB, Dykes JK, Lúquez C, Maslanka SE, Raphael BH (2015) Characterizing the fecal microbiota of infants with botulism. Microbiome 3:54. https://doi.org/10.1186/s40168-015-0119-0
doi: 10.1186/s40168-015-0119-0
Lupp C, Robertson ML, Wickham ME, Sekirov I, Champion OL, Gaynor EC, Finlay BB (2007) Host-mediated inflammation disrupts the intestinal microbiota and promotes the overgrowth of Enterobacteriaceae. Cell Host Microbe 2:119–129. https://doi.org/10.1016/j.chom.2007.06.010
doi: 10.1016/j.chom.2007.06.010
Douillard FP, Derman Y, Jian C, Korpela K, Saxén H, Salonen A, de Vos WM, Korkeala H, Lindström M (2024) Case report: aberrant fecal microbiota composition of an infant diagnosed with prolonged intestinal botulism. Gut Pathog 16:20. https://doi.org/10.1186/s13099-024-00614-y
doi: 10.1186/s13099-024-00614-y
Picard C, Fioramonti J, Francois A, Robinson T, Neant F, Matuchansky C (2005) Review article: bifidobacteria as probiotic agents—physiological effects and clinical benefits. Aliment Pharmacol Ther 22:495–512. https://doi.org/10.1111/j.1365-2036.2005.02615.x
doi: 10.1111/j.1365-2036.2005.02615.x
Sullivan NM, Mills DC, Riemann HP, Arnon SS (2011) Inhibition of growth of Clostridium botulinum by intestinal microflora isolated from healthy infants. Microb Ecol Heal Dis. https://doi.org/10.3402/mehd.v1i3.7413
doi: 10.3402/mehd.v1i3.7413
Lam TI, Tam CC, Stanker LH, Cheng LW (2016) Probiotic microorganisms inhibit epithelial cell internalization of botulinum neurotoxin serotype A. Toxins (Basel) 8:377. https://doi.org/10.3390/toxins8120377
doi: 10.3390/toxins8120377
Fernandez RA, Carbone ML, Sanchez ML, Pareja Virtudes, de Jong LIT, Bianco MI (2013) Interference of the developing and toxin production of Clostridium botulinum by Lactobacillus paracasei subspecies paracasei. International Journal of Sciences 2.
Iqbal Z, Ahmed S, Tabassum N, Bhattacharya R, Bose D (2021) Role of probiotics in prevention and treatment of enteric infections: a comprehensive review. 3 Biotech. https://doi.org/10.1007/s13205-021-02796-7
doi: 10.1007/s13205-021-02796-7
Barash JR, Castles JB, Arnon SS (2018) Antimicrobial susceptibility of 260 Clostridium botulinum type A, B, Ba, and Bf strains and a neurotoxigenic Clostridium baratii type F strain isolated from California infant botulism patients. Antimicrob Agents Chemother 62:1594. https://doi.org/10.1128/AAC.01594-18
doi: 10.1128/AAC.01594-18
Arnon SS (1980) Infant botulism. Annu Rev Med 31:541–560. https://doi.org/10.1146/annurev.me.31.020180.002545
doi: 10.1146/annurev.me.31.020180.002545
Nevas M, Lindström M, Virtanen A, Hielm S, Kuusi M, Arnon SS, Vuori E, Korkeala H (2005) Infant botulism acquired from household dust presenting as sudden infant death syndrome. J Clin Microbiol 43:511–513. https://doi.org/10.1128/JCM.43.1.511-513.2005
doi: 10.1128/JCM.43.1.511-513.2005
Midura TF (1996) Update: infant botulism. Clin Microbiol Rev 9:119–125. https://doi.org/10.1128/CMR.9.2.119
doi: 10.1128/CMR.9.2.119
Hatheway CL, McCroskey LM (1987) Examination of feces and serum for diagnosis of infant botulism in 336 patients. J Clin Microbiol 25:2334–2338. https://doi.org/10.1128/jcm.25.12.2334-2338.1987
doi: 10.1128/jcm.25.12.2334-2338.1987
Dubovsky BJ, Meyer KF (1922) An experimental study of the methods available for the enrichment, demonstration and isolation of B. botulinus in specimens of soil and its products, in suspected food, in clinical and in necropsy material. I J Infect dis 31:501–540. https://doi.org/10.1093/infdis/31.6.501
doi: 10.1093/infdis/31.6.501
Dabritz HA, Payne JR, Khouri JM (2023) Duration of fecal excretion of Clostridium botulinum and botulinum neurotoxin in children recovering from infant botulism. J Pediatr. https://doi.org/10.1016/j.jpeds.2023.113396
doi: 10.1016/j.jpeds.2023.113396