Parsing digital or analog TCR performance through piconewton forces.

Animals CD8-Positive T-Lymphocytes / immunology Mice Receptors, Antigen, T-Cell / metabolism Receptors, Antigen, T-Cell, alpha-beta / metabolism Influenza A virus / immunology Humans Lymphocyte Activation / immunology Orthomyxoviridae Infections / immunology Optical Tweezers

Journal

Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440

Informations de publication

Date de publication:
16 Aug 2024
Historique:
medline: 14 8 2024
pubmed: 14 8 2024
entrez: 14 8 2024
Statut: ppublish

Résumé

αβ T cell receptors (TCRs) principally recognize aberrant peptides bound to major histocompatibility complex molecules (pMHCs) on unhealthy cells, amplifying specificity and sensitivity through physical load placed on the TCR-pMHC bond during immunosurveillance. To understand this mechanobiology, TCRs stimulated by abundantly and sparsely arrayed epitopes (NP

Identifiants

DOI: 10.1126/sciadv.ado4313 PMID: 39141734
pubmed: 39141734
doi: 10.1126/sciadv.ado4313
doi:

Substances chimiques

Receptors, Antigen, T-Cell 0
Receptors, Antigen, T-Cell, alpha-beta 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

eado4313

Auteurs

Aoi Akitsu (A)

Laboratory of Immunobiology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
ORCID: 0000-0001-7672-9664

Eiji Kobayashi (E)

Laboratory of Immunobiology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
ORCID: 0000-0002-7303-2797

Yinnian Feng (Y)

Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN 37212, USA.

Hannah M Stephens (HM)

Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN 37212, USA.
ORCID: 0000-0002-9191-0303

Kristine N Brazin (KN)

Laboratory of Immunobiology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
ORCID: 0000-0002-4406-9179

Daniel J Masi (DJ)

Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN 37212, USA.

Evan H Kirkpatrick (EH)

Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN 37212, USA.
ORCID: 0009-0005-3439-4874

Robert J Mallis (RJ)

Laboratory of Immunobiology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
Department of Dermatology, Harvard Medical School, Boston, MA 02115, USA.
ORCID: 0000-0002-2087-9468

Jonathan S Duke-Cohan (JS)

Laboratory of Immunobiology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
ORCID: 0000-0002-9478-9609

Matthew A Booker (MA)

Department of Informatics and Analytics, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
ORCID: 0000-0002-6902-1032

Vincenzo Cinella (V)

Laboratory of Immunobiology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
ORCID: 0009-0002-8555-2906

William W Feng (WW)

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
ORCID: 0000-0002-8976-5020

Elizabeth L Holliday (EL)

Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN 37212, USA.
ORCID: 0000-0003-4069-2606

Jonathan J Lee (JJ)

Laboratory of Immunobiology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
ORCID: 0009-0006-9700-2548

Katarzyna J Zienkiewicz (KJ)

Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN 37212, USA.

Michael Y Tolstorukov (MY)

Department of Informatics and Analytics, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
ORCID: 0000-0002-9134-8808

Wonmuk Hwang (W)

Departments of Biomedical Engineering, Materials Science and Engineering, Physics and Astronomy, Texas A&M University, College Station, TX 77843, USA.
ORCID: 0000-0001-7514-3186

Matthew J Lang (MJ)

Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN 37212, USA.
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
ORCID: 0000-0002-8198-144X

Ellis L Reinherz (EL)

Laboratory of Immunobiology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
ORCID: 0000-0003-1048-5526

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Parsing digital or analog TCR performance...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD8+ › Parsing digital or analog TCR performance...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Parsing digital or analog TCR performance...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs aux antigènes › Récepteurs aux antigènes des cellules T › Parsing digital or analog TCR performance...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs aux antigènes › Récepteurs aux antigènes des cellules T › Récepteur lymphocytaire T antigène, alpha-bêta › Parsing digital or analog TCR performance...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN de polarité négative › Orthomyxoviridae › Influenzavirus A › Virus de la grippe A › Parsing digital or analog TCR performance...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Parsing digital or analog TCR performance...
questionsmedicales.fr › Phénomènes du système immunitaire › Activation des lymphocytes › Parsing digital or analog TCR performance...
questionsmedicales.fr › Infection › Maladies virales › Infections à virus à ARN › Infections à Orthomyxoviridae › Parsing digital or analog TCR performance...
questionsmedicales.fr › Techniques d'investigation › Pinces optiques › Parsing digital or analog TCR performance...