Bacteria modulate microalgal aging physiology through the induction of extracellular vesicle production to remove harmful metabolites.
Journal
Nature microbiology
ISSN: 2058-5276
Titre abrégé: Nat Microbiol
Pays: England
ID NLM: 101674869
Informations de publication
Date de publication:
14 Aug 2024
14 Aug 2024
Historique:
received:
24
01
2023
accepted:
30
05
2024
medline:
15
8
2024
pubmed:
15
8
2024
entrez:
14
8
2024
Statut:
aheadofprint
Résumé
The bloom and bust patterns of microalgae in aquatic systems contribute massively to global biogeochemical cycles. The decline of algal blooms is mainly caused by nutrient limitation resulting in cell death, the arrest of cell division and the aging of surviving cells. Nutrient intake can re-initiate proliferation, but the processes involved are poorly understood. Here we characterize how the bloom-forming diatom Coscinodiscus radiatus recovers from starvation after nutrient influx. Rejuvenation is mediated by extracellular vesicles that shuttle reactive oxygen species, oxylipins and other harmful metabolites out of the old cells, thereby re-enabling their proliferation. By administering nutrient pulses to aged cells and metabolomic monitoring of the response, we show that regulated pathways are centred around the methionine cycle in C. radiatus. Co-incubation experiments show that bacteria mediate aging processes and trigger vesicle production using chemical signalling. This work opens new perspectives on cellular aging and rejuvenation in complex microbial communities.
Identifiants
pubmed: 39143356
doi: 10.1038/s41564-024-01746-2
pii: 10.1038/s41564-024-01746-2
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Deutsche Forschungsgemeinschaft (German Research Foundation)
ID : 239748522
Organisme : Deutsche Forschungsgemeinschaft (German Research Foundation)
ID : 390713860
Organisme : Deutsche Forschungsgemeinschaft (German Research Foundation)
ID : - EXC 2051 Project-ID 390713860
Organisme : Deutsche Forschungsgemeinschaft (German Research Foundation)
ID : 390713860
Organisme : Deutsche Forschungsgemeinschaft (German Research Foundation)
ID : 239748522
Organisme : Deutsche Forschungsgemeinschaft (German Research Foundation)
ID : 239748522
Organisme : Deutsche Forschungsgemeinschaft (German Research Foundation)
ID : 390713860
Informations de copyright
© 2024. The Author(s).
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